ENSG00000174606

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000360506 ENSG00000174606 HEK293_OSMI2_2hA HEK293_TMG_2hB ANGEL2 protein_coding protein_coding 14.86385 6.120989 26.07987 0.9799052 0.9215361 2.089298 1.6636662 1.7142217 2.3535863 0.53079244 0.35200390 0.4550322 0.13402083 0.26850000 0.08970000 -0.17880000 1.289916e-02 1.671438e-16 FALSE TRUE
ENST00000366962 ENSG00000174606 HEK293_OSMI2_2hA HEK293_TMG_2hB ANGEL2 protein_coding protein_coding 14.86385 6.120989 26.07987 0.9799052 0.9215361 2.089298 5.1536280 2.5948959 9.2176382 0.67387579 0.18809135 1.8247357 0.36302083 0.41533333 0.35470000 -0.06063333 6.345185e-01 1.671438e-16 FALSE TRUE
ENST00000460337 ENSG00000174606 HEK293_OSMI2_2hA HEK293_TMG_2hB ANGEL2 protein_coding processed_transcript 14.86385 6.120989 26.07987 0.9799052 0.9215361 2.089298 0.5782365 0.6029021 0.6745681 0.09081890 0.20536959 0.1595374 0.05234167 0.10066667 0.02650000 -0.07416667 1.278295e-02 1.671438e-16 FALSE TRUE
ENST00000473303 ENSG00000174606 HEK293_OSMI2_2hA HEK293_TMG_2hB ANGEL2 protein_coding processed_transcript 14.86385 6.120989 26.07987 0.9799052 0.9215361 2.089298 0.8806650 0.2624503 1.2919138 0.05389290 0.06392801 2.2565691 0.07069583 0.04573333 0.04953333 0.00380000 7.993256e-01 1.671438e-16   FALSE
ENST00000481918 ENSG00000174606 HEK293_OSMI2_2hA HEK293_TMG_2hB ANGEL2 protein_coding processed_transcript 14.86385 6.120989 26.07987 0.9799052 0.9215361 2.089298 2.1230697 0.3906150 4.0298671 0.20546473 0.63061267 3.3340194 0.12584167 0.07743333 0.15333333 0.07590000 5.880272e-01 1.671438e-16   FALSE
ENST00000498650 ENSG00000174606 HEK293_OSMI2_2hA HEK293_TMG_2hB ANGEL2 protein_coding processed_transcript 14.86385 6.120989 26.07987 0.9799052 0.9215361 2.089298 0.5183722 0.1509415 1.3311809 0.07595470 0.35843762 3.0588959 0.05015000 0.02920000 0.05073333 0.02153333 6.735539e-01 1.671438e-16   FALSE
MSTRG.3038.9 ENSG00000174606 HEK293_OSMI2_2hA HEK293_TMG_2hB ANGEL2 protein_coding   14.86385 6.120989 26.07987 0.9799052 0.9215361 2.089298 2.1666680 0.0590448 5.2015738 0.04341435 0.40916963 6.2380425 0.09176250 0.01163333 0.19900000 0.18736667 1.671438e-16 1.671438e-16 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000174606 E001 392.337037 0.0082969921 9.682571e-17 4.171785e-15 1 212992182 212993991 1810 - 2.394 2.797 1.340
ENSG00000174606 E002 184.682182 0.0002301148 5.305513e-01 6.631524e-01 1 212993992 212994728 737 - 2.183 2.277 0.315
ENSG00000174606 E003 30.907178 0.0006681859 5.161055e-03 1.636724e-02 1 212994729 212994845 117 - 1.369 1.628 0.887
ENSG00000174606 E004 22.492933 0.0008144733 3.088086e-03 1.052475e-02 1 212994846 212994927 82 - 1.222 1.519 1.032
ENSG00000174606 E005 16.718089 0.0010867758 4.029889e-01 5.467942e-01 1 212994928 212994938 11 - 1.151 1.298 0.520
ENSG00000174606 E006 113.162345 0.0029648906 9.185387e-03 2.674840e-02 1 212994939 212995192 254 - 2.008 1.964 -0.147
ENSG00000174606 E007 76.324087 0.0009425846 1.964248e-05 1.220949e-04 1 212997155 212997199 45 - 1.857 1.715 -0.479
ENSG00000174606 E008 107.421440 0.0002905292 5.070082e-05 2.853231e-04 1 212997200 212997318 119 - 1.994 1.907 -0.293
ENSG00000174606 E009 76.373268 0.0022437563 3.965565e-03 1.304650e-02 1 213000326 213000379 54 - 1.845 1.768 -0.257
ENSG00000174606 E010 51.526082 0.0039120658 1.210567e-01 2.214503e-01 1 213000380 213000383 4 - 1.666 1.640 -0.089
ENSG00000174606 E011 3.573151 0.0049610326 4.361692e-01 5.782807e-01 1 213000384 213000570 187 - 0.623 0.546 -0.348
ENSG00000174606 E012 83.805260 0.0004581037 4.392169e-02 9.824351e-02 1 213000786 213000912 127 - 1.871 1.857 -0.047
ENSG00000174606 E013 29.342379 0.0342793956 5.625584e-01 6.901280e-01 1 213000913 213002234 1322 - 1.419 1.402 -0.058
ENSG00000174606 E014 68.297472 0.0003914979 1.045332e-04 5.429635e-04 1 213005033 213005124 92 - 1.806 1.682 -0.419
ENSG00000174606 E015 134.443452 0.0007202588 3.934039e-04 1.749470e-03 1 213005125 213005454 330 - 2.082 2.025 -0.190
ENSG00000174606 E016 11.729719 0.0157239913 1.506887e-06 1.204486e-05 1 213006539 213007128 590 - 0.806 1.406 2.182
ENSG00000174606 E017 75.594762 0.0026897397 1.486452e-01 2.598301e-01 1 213007129 213007198 70 - 1.822 1.817 -0.017
ENSG00000174606 E018 150.014649 0.0002271409 4.215623e-08 4.616399e-07 1 213008210 213008466 257 - 2.142 2.030 -0.375
ENSG00000174606 E019 3.623540 0.0126419244 7.020024e-01 8.009314e-01 1 213011208 213011463 256 - 0.623 0.617 -0.030
ENSG00000174606 E020 149.837815 0.0004155737 2.981200e-12 6.768689e-11 1 213013093 213013418 326 - 2.154 1.979 -0.587
ENSG00000174606 E021 2.643244 0.1959955938 3.479563e-01 4.921664e-01 1 213015149 213015225 77 - 0.454 0.675 1.014
ENSG00000174606 E022 26.114242 0.0035577096 2.330382e-01 3.660333e-01 1 213015226 213015438 213 - 1.379 1.350 -0.101
ENSG00000174606 E023 8.986617 0.0023329223 5.619453e-01 6.896611e-01 1 213015439 213015608 170 - 0.907 1.043 0.507
ENSG00000174606 E024 0.000000       1 213015609 213015612 4 -      
ENSG00000174606 E025 37.785854 0.0172345784 4.978692e-02 1.087837e-01 1 213015613 213015653 41 - 1.552 1.419 -0.457
ENSG00000174606 E026 46.410803 0.0170049116 3.775343e-02 8.687640e-02 1 213015654 213015867 214 - 1.640 1.505 -0.460