ENSG00000174516

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000320740 ENSG00000174516 HEK293_OSMI2_2hA HEK293_TMG_2hB PELI3 protein_coding protein_coding 7.388948 13.16952 4.192324 0.150944 0.1749788 -1.649039 4.65160771 8.2827164 3.1939456 1.18900520 0.1508966 -1.371995 0.64169583 0.62960000 0.76193333 0.13233333 4.880162e-01 3.041071e-05 FALSE TRUE
ENST00000349459 ENSG00000174516 HEK293_OSMI2_2hA HEK293_TMG_2hB PELI3 protein_coding protein_coding 7.388948 13.16952 4.192324 0.150944 0.1749788 -1.649039 0.96620613 1.5214736 0.4166187 0.32840123 0.2367085 -1.843902 0.12781667 0.11523333 0.09670000 -0.01853333 8.045013e-01 3.041071e-05 FALSE TRUE
ENST00000524466 ENSG00000174516 HEK293_OSMI2_2hA HEK293_TMG_2hB PELI3 protein_coding protein_coding 7.388948 13.16952 4.192324 0.150944 0.1749788 -1.649039 0.55154501 0.7857067 0.3304495 0.08089142 0.1295898 -1.224796 0.08054167 0.05960000 0.07650000 0.01690000 8.849093e-01 3.041071e-05 FALSE TRUE
ENST00000526296 ENSG00000174516 HEK293_OSMI2_2hA HEK293_TMG_2hB PELI3 protein_coding protein_coding 7.388948 13.16952 4.192324 0.150944 0.1749788 -1.649039 0.36884758 1.1774032 0.0000000 0.39370719 0.0000000 -6.891666 0.04768750 0.08940000 0.00000000 -0.08940000 3.041071e-05 3.041071e-05 FALSE TRUE
ENST00000531856 ENSG00000174516 HEK293_OSMI2_2hA HEK293_TMG_2hB PELI3 protein_coding processed_transcript 7.388948 13.16952 4.192324 0.150944 0.1749788 -1.649039 0.65532411 1.0895039 0.0000000 1.08950393 0.0000000 -6.780709 0.07037500 0.08273333 0.00000000 -0.08273333 9.513236e-01 3.041071e-05 FALSE TRUE
ENST00000532970 ENSG00000174516 HEK293_OSMI2_2hA HEK293_TMG_2hB PELI3 protein_coding nonsense_mediated_decay 7.388948 13.16952 4.192324 0.150944 0.1749788 -1.649039 0.07605442 0.1614314 0.2513103 0.08328733 0.2513103 0.608133 0.01707500 0.01213333 0.06486667 0.05273333 9.352536e-01 3.041071e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000174516 E001 0.0000000       11 66466327 66466445 119 +      
ENSG00000174516 E002 0.5503986 0.0199658168 0.7117650159 0.808660707 11 66466745 66466904 160 + 0.194 0.139 -0.572
ENSG00000174516 E003 1.3704169 0.0106848110 0.1212734873 0.221739744 11 66466905 66466917 13 + 0.511 0.244 -1.573
ENSG00000174516 E004 3.5773390 0.0047398488 0.0006145312 0.002586561 11 66466918 66466923 6 + 0.919 0.431 -2.104
ENSG00000174516 E005 3.9042161 0.0052127643 0.0004771311 0.002072524 11 66466924 66466925 2 + 0.948 0.460 -2.059
ENSG00000174516 E006 9.8463000 0.0051318998 0.0099312317 0.028591172 11 66466926 66466957 32 + 1.144 0.871 -1.006
ENSG00000174516 E007 22.4402252 0.0018533359 0.0008847717 0.003560872 11 66466958 66467027 70 + 1.455 1.212 -0.846
ENSG00000174516 E008 0.5149111 0.0199976474 0.7101470989 0.807364824 11 66467392 66467558 167 + 0.194 0.139 -0.574
ENSG00000174516 E009 49.5774230 0.0035083044 0.0210773862 0.053759594 11 66468128 66468269 142 + 1.703 1.584 -0.402
ENSG00000174516 E010 27.3612014 0.0007621502 0.3697406444 0.514138695 11 66468270 66468280 11 + 1.401 1.352 -0.167
ENSG00000174516 E011 36.2490264 0.0006254996 0.4690931194 0.608395182 11 66468833 66468904 72 + 1.504 1.475 -0.097
ENSG00000174516 E012 66.8447481 0.0007510000 0.6128953067 0.731727032 11 66471242 66471347 106 + 1.744 1.739 -0.017
ENSG00000174516 E013 38.6491382 0.0007060966 0.8896799677 0.933489891 11 66471348 66471362 15 + 1.488 1.517 0.100
ENSG00000174516 E014 35.3638347 0.0007013178 0.9953253985 1.000000000 11 66471363 66471371 9 + 1.455 1.475 0.070
ENSG00000174516 E015 0.9138074 0.1529149881 0.8572862063 0.911869269 11 66471372 66471374 3 + 0.194 0.247 0.446
ENSG00000174516 E016 0.7728880 0.0153787590 0.2926130771 0.433584689 11 66472348 66472368 21 + 0.001 0.244 9.355
ENSG00000174516 E017 72.8751284 0.0005128572 0.6210770218 0.738092475 11 66472369 66472470 102 + 1.782 1.779 -0.011
ENSG00000174516 E018 98.0565377 0.0050821141 0.8740270682 0.923021813 11 66473241 66473423 183 + 1.898 1.914 0.054
ENSG00000174516 E019 43.6075864 0.0006394956 0.4338264214 0.576230038 11 66473424 66473435 12 + 1.587 1.560 -0.093
ENSG00000174516 E020 88.2452545 0.0003738372 0.7938656704 0.868243887 11 66473737 66473925 189 + 1.856 1.865 0.031
ENSG00000174516 E021 14.2830110 0.0049314510 0.7924448278 0.867295767 11 66473926 66474651 726 + 1.107 1.098 -0.034
ENSG00000174516 E022 2.2455145 0.0066598963 0.5984414726 0.720033925 11 66475572 66475597 26 + 0.511 0.431 -0.404
ENSG00000174516 E023 73.2888865 0.0027161062 0.0861114110 0.169172206 11 66475598 66475790 193 + 1.688 1.804 0.391
ENSG00000174516 E024 401.5526990 0.0048836646 0.0066399736 0.020288755 11 66475791 66477337 1547 + 2.440 2.541 0.336