ENSG00000174442

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000307897 ENSG00000174442 HEK293_OSMI2_2hA HEK293_TMG_2hB ZWILCH protein_coding protein_coding 19.5625 5.895362 35.59672 0.2051799 0.7583109 2.592052 11.2944004 5.2021803 17.855439 0.2550249 0.9182416 1.777212 0.67105000 0.88393333 0.50143333 -0.38250000 2.869078e-05 2.82007e-13 FALSE TRUE
ENST00000446801 ENSG00000174442 HEK293_OSMI2_2hA HEK293_TMG_2hB ZWILCH protein_coding protein_coding 19.5625 5.895362 35.59672 0.2051799 0.7583109 2.592052 1.5214650 0.3581536 3.027726 0.1436227 0.2789615 3.044612 0.07178750 0.06023333 0.08516667 0.02493333 5.932305e-01 2.82007e-13 FALSE TRUE
ENST00000564179 ENSG00000174442 HEK293_OSMI2_2hA HEK293_TMG_2hB ZWILCH protein_coding protein_coding 19.5625 5.895362 35.59672 0.2051799 0.7583109 2.592052 2.0562889 0.0000000 5.078620 0.0000000 0.7860317 8.991131 0.06162917 0.00000000 0.14280000 0.14280000 1.623767e-11 2.82007e-13 FALSE FALSE
ENST00000565627 ENSG00000174442 HEK293_OSMI2_2hA HEK293_TMG_2hB ZWILCH protein_coding protein_coding 19.5625 5.895362 35.59672 0.2051799 0.7583109 2.592052 3.0166213 0.0000000 5.289191 0.0000000 0.7768409 9.049628 0.09214583 0.00000000 0.14810000 0.14810000 2.820070e-13 2.82007e-13 FALSE TRUE
ENST00000567816 ENSG00000174442 HEK293_OSMI2_2hA HEK293_TMG_2hB ZWILCH protein_coding protein_coding 19.5625 5.895362 35.59672 0.2051799 0.7583109 2.592052 0.5894334 0.0000000 2.361240 0.0000000 1.1742268 7.889498 0.03757500 0.00000000 0.06640000 0.06640000 2.182529e-03 2.82007e-13 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000174442 E001 0.0000000       15 66504959 66505082 124 +      
ENSG00000174442 E002 0.2924217 0.0290785164 1.000000e+00   15 66505083 66505116 34 + 0.111 0.000 -9.465
ENSG00000174442 E003 10.5347687 0.0017424578 2.094674e-01 0.3378999725 15 66505117 66505294 178 + 0.990 0.876 -0.431
ENSG00000174442 E004 7.0552777 0.0181436387 5.685041e-01 0.6951795885 15 66505295 66505299 5 + 0.787 0.917 0.505
ENSG00000174442 E005 22.4814051 0.0390146474 2.856361e-01 0.4259952082 15 66505300 66505325 26 + 1.288 1.197 -0.321
ENSG00000174442 E006 56.2848054 0.0040647983 1.372408e-03 0.0052163495 15 66505326 66505391 66 + 1.688 1.517 -0.581
ENSG00000174442 E007 0.1482932 0.0413200928 9.668304e-02   15 66505392 66505400 9 + 0.000 0.236 12.789
ENSG00000174442 E008 3.7697201 0.0040970527 1.316306e-01 0.2364079533 15 66508746 66508840 95 + 0.640 0.389 -1.218
ENSG00000174442 E009 69.7252923 0.0072565381 2.581123e-03 0.0090080880 15 66508841 66508892 52 + 1.777 1.620 -0.532
ENSG00000174442 E010 0.1515154 0.0424148098 1.000000e+00   15 66513934 66513987 54 + 0.059 0.000 -8.457
ENSG00000174442 E011 104.7667299 0.0034225258 1.747633e-04 0.0008558847 15 66513988 66514083 96 + 1.950 1.802 -0.497
ENSG00000174442 E012 0.1515154 0.0424148098 1.000000e+00   15 66514327 66514522 196 + 0.059 0.000 -8.457
ENSG00000174442 E013 132.4482047 0.0113243764 1.096685e-02 0.0310845361 15 66515526 66515644 119 + 2.045 1.938 -0.359
ENSG00000174442 E014 69.3339111 0.0003507325 3.724571e-04 0.0016675531 15 66518879 66518882 4 + 1.773 1.626 -0.498
ENSG00000174442 E015 121.6113083 0.0003128166 2.261160e-04 0.0010752260 15 66518883 66518969 87 + 2.006 1.906 -0.335
ENSG00000174442 E016 127.0496061 0.0003457357 1.862990e-03 0.0067987706 15 66518970 66519078 109 + 2.021 1.951 -0.237
ENSG00000174442 E017 0.5954526 0.0185030409 4.560522e-01 0.5965251109 15 66519079 66519129 51 + 0.200 0.000 -10.456
ENSG00000174442 E018 1.1501176 0.0133855780 5.324385e-01 0.6648006803 15 66520508 66520589 82 + 0.239 0.389 0.985
ENSG00000174442 E019 90.2456387 0.0034948983 6.128866e-02 0.1288087951 15 66520590 66520660 71 + 1.868 1.822 -0.158
ENSG00000174442 E020 0.0000000       15 66520661 66520664 4 +      
ENSG00000174442 E021 143.2720336 0.0030563142 9.939000e-03 0.0286089949 15 66521050 66521205 156 + 2.070 2.008 -0.208
ENSG00000174442 E022 0.0000000       15 66523511 66523676 166 +      
ENSG00000174442 E023 98.2705976 0.0004117627 4.131703e-03 0.0135108687 15 66523677 66523748 72 + 1.912 1.834 -0.261
ENSG00000174442 E024 94.6404121 0.0003502149 2.864206e-02 0.0692933235 15 66527290 66527383 94 + 1.890 1.844 -0.155
ENSG00000174442 E025 87.4516676 0.0033603628 2.111600e-02 0.0538443029 15 66527857 66527912 56 + 1.861 1.786 -0.254
ENSG00000174442 E026 108.3427402 0.0003415895 2.297417e-01 0.3621466903 15 66528852 66528957 106 + 1.938 1.944 0.018
ENSG00000174442 E027 110.3577550 0.0002673744 6.852119e-01 0.7880200969 15 66529494 66529573 80 + 1.938 1.978 0.133
ENSG00000174442 E028 139.6902200 0.0002231142 9.267866e-02 0.1793145069 15 66532247 66532403 157 + 2.049 2.042 -0.022
ENSG00000174442 E029 75.7018271 0.0003685183 9.685656e-01 0.9843349178 15 66532985 66533013 29 + 1.772 1.830 0.197
ENSG00000174442 E030 158.5144917 0.0003124160 4.231374e-01 0.5662565058 15 66535933 66536069 137 + 2.086 2.170 0.281
ENSG00000174442 E031 75.1447823 0.0003591655 8.603955e-01 0.9139498931 15 66537168 66537168 1 + 1.769 1.834 0.219
ENSG00000174442 E032 153.9594981 0.0002535144 9.125004e-01 0.9485503636 15 66537169 66537263 95 + 2.079 2.139 0.203
ENSG00000174442 E033 136.7675624 0.0020746517 9.945231e-01 1.0000000000 15 66540098 66540152 55 + 2.029 2.086 0.191
ENSG00000174442 E034 121.7122380 0.0022950822 5.668677e-01 0.6937472781 15 66540153 66540210 58 + 1.972 2.054 0.276
ENSG00000174442 E035 155.1398842 0.0004569175 4.854117e-02 0.1065828564 15 66546591 66546705 115 + 2.064 2.189 0.418
ENSG00000174442 E036 1.4113182 0.0727058943 7.938517e-01 0.8682438873 15 66546706 66546887 182 + 0.307 0.389 0.498
ENSG00000174442 E037 0.9504292 0.3451207565 3.818254e-01 0.5260930184 15 66547243 66547292 50 + 0.199 0.390 1.320
ENSG00000174442 E038 516.8023478 0.0227736693 4.293673e-05 0.0002457547 15 66548351 66550130 1780 + 2.530 2.852 1.071