ENSG00000174437

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000308664 ENSG00000174437 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP2A2 protein_coding protein_coding 105.2456 64.93906 133.7949 2.464748 2.135527 1.04275 5.951962 0.3379337 16.44535 0.09800441 0.9039911 5.5635999 0.04513333 0.005133333 0.1227667 0.11763333 2.680863e-47 2.680863e-47 FALSE TRUE
ENST00000539276 ENSG00000174437 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP2A2 protein_coding protein_coding 105.2456 64.93906 133.7949 2.464748 2.135527 1.04275 18.121094 14.5290131 25.25968 0.24367725 0.4624299 0.7974783 0.18307500 0.224166667 0.1888333 -0.03533333 6.411243e-02 2.680863e-47 FALSE TRUE
ENST00000548169 ENSG00000174437 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP2A2 protein_coding protein_coding 105.2456 64.93906 133.7949 2.464748 2.135527 1.04275 53.358994 35.9277579 61.86891 1.28153861 1.7146187 0.7839474 0.51300000 0.553533333 0.4622667 -0.09126667 3.381412e-04 2.680863e-47 FALSE TRUE
MSTRG.8001.6 ENSG00000174437 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP2A2 protein_coding   105.2456 64.93906 133.7949 2.464748 2.135527 1.04275 22.408379 12.8284739 22.03407 1.30657968 1.3482627 0.7799172 0.21084583 0.196700000 0.1647333 -0.03196667 4.431700e-01 2.680863e-47 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000174437 E001 0.9662231 0.0782430574 3.554268e-01 4.997628e-01 12 110280756 110280964 209 + 0.336 0.163 -1.359
ENSG00000174437 E002 6.6319210 0.0211968962 3.341338e-02 7.860310e-02 12 110281116 110281246 131 + 0.963 0.665 -1.175
ENSG00000174437 E003 65.2440795 0.0566751970 1.267205e-06 1.029540e-05 12 110281247 110281296 50 + 1.956 1.355 -2.044
ENSG00000174437 E004 110.7344245 0.0510764575 9.750514e-07 8.107468e-06 12 110281297 110281501 205 + 2.176 1.625 -1.854
ENSG00000174437 E005 537.8425657 0.0076912382 7.176491e-12 1.529835e-10 12 110281502 110281907 406 + 2.811 2.515 -0.985
ENSG00000174437 E006 0.1451727 0.0432778409 8.931422e-01   12 110281908 110281918 11 + 0.091 0.000 -8.553
ENSG00000174437 E007 249.4212554 0.0120841397 2.949475e-04 1.359338e-03 12 110282604 110282621 18 + 2.450 2.260 -0.636
ENSG00000174437 E008 398.8054653 0.0090548765 1.288587e-04 6.538812e-04 12 110282713 110282795 83 + 2.647 2.478 -0.564
ENSG00000174437 E009 311.7625908 0.0059393668 1.419082e-08 1.701021e-07 12 110292020 110292048 29 + 2.557 2.327 -0.766
ENSG00000174437 E010 443.6160285 0.0056995515 6.205073e-06 4.324991e-05 12 110292049 110292124 76 + 2.691 2.527 -0.548
ENSG00000174437 E011 1.0393897 0.0119049760 2.797407e-02 6.796106e-02 12 110295991 110296314 324 + 0.421 0.000 -11.361
ENSG00000174437 E012 709.9913089 0.0016046251 3.111902e-07 2.869369e-06 12 110296599 110296737 139 + 2.876 2.773 -0.341
ENSG00000174437 E013 678.1466164 0.0001591079 1.586840e-19 9.607611e-18 12 110322992 110323072 81 + 2.861 2.741 -0.401
ENSG00000174437 E014 6.9598953 0.0023863706 5.445758e-06 3.844684e-05 12 110325801 110326389 589 + 1.043 0.373 -2.885
ENSG00000174437 E015 730.2392719 0.0003884532 3.931748e-20 2.542177e-18 12 110326390 110326475 86 + 2.898 2.763 -0.449
ENSG00000174437 E016 879.8160442 0.0025459719 3.305732e-05 1.945998e-04 12 110327553 110327686 134 + 2.965 2.872 -0.309
ENSG00000174437 E017 1184.3421085 0.0026619148 3.837581e-04 1.711839e-03 12 110327687 110328017 331 + 3.088 3.015 -0.246
ENSG00000174437 E018 2.0786777 0.0069551681 8.337902e-02 1.648584e-01 12 110329399 110331971 2573 + 0.580 0.280 -1.631
ENSG00000174437 E019 2.6906001 0.0057322819 6.272350e-01 7.430545e-01 12 110331972 110332596 625 + 0.580 0.514 -0.307
ENSG00000174437 E020 606.5022884 0.0031326483 3.244107e-02 7.670537e-02 12 110332597 110332685 89 + 2.788 2.743 -0.150
ENSG00000174437 E021 696.3803788 0.0046381409 8.951239e-03 2.615823e-02 12 110333181 110333283 103 + 2.858 2.786 -0.241
ENSG00000174437 E022 919.5062454 0.0009640231 2.050683e-05 1.268930e-04 12 110334012 110334143 132 + 2.975 2.913 -0.206
ENSG00000174437 E023 2.4785032 0.0105073046 4.892252e-01 6.266879e-01 12 110334144 110334291 148 + 0.492 0.620 0.590
ENSG00000174437 E024 765.0652359 0.0001756261 2.895825e-03 9.958349e-03 12 110339281 110339403 123 + 2.881 2.857 -0.079
ENSG00000174437 E025 1028.4515049 0.0002001223 8.500509e-02 1.674119e-01 12 110339503 110339721 219 + 3.002 2.999 -0.009
ENSG00000174437 E026 1340.8354782 0.0000782016 2.330634e-01 3.660578e-01 12 110340659 110340994 336 + 3.113 3.120 0.024
ENSG00000174437 E027 1126.6160829 0.0000977285 1.327071e-01 2.378678e-01 12 110342228 110342448 221 + 3.025 3.062 0.123
ENSG00000174437 E028 508.1695989 0.0001367888 6.514628e-02 1.352775e-01 12 110343232 110343255 24 + 2.675 2.725 0.169
ENSG00000174437 E029 940.6139441 0.0001333916 5.957060e-04 2.517617e-03 12 110343256 110343434 179 + 2.936 2.999 0.211
ENSG00000174437 E030 564.9371117 0.0001018919 1.463224e-06 1.173000e-05 12 110344886 110344971 86 + 2.702 2.797 0.316
ENSG00000174437 E031 8.5386697 0.0571628987 1.685222e-01 2.862400e-01 12 110344972 110345247 276 + 1.035 0.813 -0.840
ENSG00000174437 E032 856.9661100 0.0012612826 4.178676e-02 9.433804e-02 12 110345249 110345382 134 + 2.897 2.960 0.209
ENSG00000174437 E033 42.5689855 0.0004910276 5.688127e-15 1.941619e-13 12 110345437 110346000 564 + 1.756 1.271 -1.666
ENSG00000174437 E034 1019.0474894 0.0014591604 6.372866e-02 1.329070e-01 12 110346001 110346118 118 + 2.973 3.033 0.201
ENSG00000174437 E035 1146.8778207 0.0023734107 2.944439e-02 7.086337e-02 12 110346201 110346321 121 + 3.017 3.094 0.254
ENSG00000174437 E036 2627.9207371 0.0021683378 1.796406e-24 1.870939e-22 12 110346322 110347392 1071 + 3.299 3.540 0.800
ENSG00000174437 E037 101.8404534 0.0002982193 1.360817e-02 3.732645e-02 12 110347393 110347453 61 + 2.026 1.953 -0.243
ENSG00000174437 E038 246.2875561 0.0029308493 3.864631e-01 5.306419e-01 12 110347454 110347791 338 + 2.383 2.372 -0.039
ENSG00000174437 E039 1518.3573340 0.0026509151 2.724069e-06 2.058503e-05 12 110347792 110350291 2500 + 3.110 3.251 0.468
ENSG00000174437 E040 611.7595354 0.0053309346 3.927593e-20 2.541202e-18 12 110350292 110351146 855 + 2.592 2.966 1.245