ENSG00000174365

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000421599 ENSG00000174365 HEK293_OSMI2_2hA HEK293_TMG_2hB SNHG11 lncRNA lncRNA 25.11376 43.31068 14.84128 2.079686 0.3980366 -1.544468 1.311538 2.320265 0.9762744 0.83774345 0.1881874 -1.2404333 0.05155417 0.05203333 0.06560000 0.01356667 7.662256e-01 3.989922e-46 TRUE FALSE
ENST00000457218 ENSG00000174365 HEK293_OSMI2_2hA HEK293_TMG_2hB SNHG11 lncRNA lncRNA 25.11376 43.31068 14.84128 2.079686 0.3980366 -1.544468 2.133049 1.534178 1.2539058 1.53417779 0.7535695 -0.2889499 0.08944583 0.03766667 0.08190000 0.04423333 4.890771e-01 3.989922e-46   FALSE
ENST00000656815 ENSG00000174365 HEK293_OSMI2_2hA HEK293_TMG_2hB SNHG11 lncRNA lncRNA 25.11376 43.31068 14.84128 2.079686 0.3980366 -1.544468 2.906592 9.370331 0.0000000 0.82809632 0.0000000 -9.8734950 0.10329583 0.21563333 0.00000000 -0.21563333 3.989922e-46 3.989922e-46 TRUE FALSE
ENST00000657911 ENSG00000174365 HEK293_OSMI2_2hA HEK293_TMG_2hB SNHG11 lncRNA lncRNA 25.11376 43.31068 14.84128 2.079686 0.3980366 -1.544468 4.381592 8.779825 2.0012795 0.28450410 0.3843680 -2.1277209 0.15034167 0.20416667 0.13580000 -0.06836667 3.051422e-01 3.989922e-46 TRUE FALSE
ENST00000661733 ENSG00000174365 HEK293_OSMI2_2hA HEK293_TMG_2hB SNHG11 lncRNA lncRNA 25.11376 43.31068 14.84128 2.079686 0.3980366 -1.544468 1.521903 1.682841 0.4008827 0.16673395 0.2012696 -2.0426480 0.06910417 0.03910000 0.02703333 -0.01206667 7.363307e-01 3.989922e-46 TRUE FALSE
ENST00000667760 ENSG00000174365 HEK293_OSMI2_2hA HEK293_TMG_2hB SNHG11 lncRNA lncRNA 25.11376 43.31068 14.84128 2.079686 0.3980366 -1.544468 0.329412 0.000000 1.0127144 0.00000000 0.8580805 6.6762595 0.01555833 0.00000000 0.06600000 0.06600000 1.388558e-01 3.989922e-46 TRUE FALSE
ENST00000669083 ENSG00000174365 HEK293_OSMI2_2hA HEK293_TMG_2hB SNHG11 lncRNA lncRNA 25.11376 43.31068 14.84128 2.079686 0.3980366 -1.544468 1.292946 3.765764 0.0000000 0.74676133 0.0000000 -8.5606249 0.04017917 0.08646667 0.00000000 -0.08646667 5.644317e-13 3.989922e-46 TRUE FALSE
ENST00000670898 ENSG00000174365 HEK293_OSMI2_2hA HEK293_TMG_2hB SNHG11 lncRNA retained_intron 25.11376 43.31068 14.84128 2.079686 0.3980366 -1.544468 2.509389 3.590704 2.6335865 0.75082754 0.3948269 -0.4457825 0.11065417 0.08170000 0.17666667 0.09496667 1.883456e-02 3.989922e-46 TRUE FALSE
ENST00000693500 ENSG00000174365 HEK293_OSMI2_2hA HEK293_TMG_2hB SNHG11 lncRNA lncRNA 25.11376 43.31068 14.84128 2.079686 0.3980366 -1.544468 2.634091 4.090644 1.9769222 0.92563261 0.1904516 -1.0453150 0.12054167 0.09296667 0.13353333 0.04056667 3.611241e-01 3.989922e-46   FALSE
MSTRG.20698.22 ENSG00000174365 HEK293_OSMI2_2hA HEK293_TMG_2hB SNHG11 lncRNA   25.11376 43.31068 14.84128 2.079686 0.3980366 -1.544468 1.724063 2.852576 1.4767299 0.09885904 0.7402758 -0.9451713 0.06435833 0.06630000 0.10193333 0.03563333 1.000000e+00 3.989922e-46   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000174365 E001 0.1515154 0.0425661945 0.1321798035   20 38446343 38446504 162 + 0.205 0.000 -11.147
ENSG00000174365 E002 0.0000000       20 38446578 38446619 42 +      
ENSG00000174365 E003 0.0000000       20 38446620 38446620 1 +      
ENSG00000174365 E004 0.5514428 0.0196604697 0.4986698620 0.635114017 20 38446621 38446648 28 + 0.000 0.184 12.463
ENSG00000174365 E005 0.5514428 0.0196604697 0.4986698620 0.635114017 20 38446649 38446649 1 + 0.000 0.184 12.463
ENSG00000174365 E006 0.5514428 0.0196604697 0.4986698620 0.635114017 20 38446650 38446653 4 + 0.000 0.184 12.463
ENSG00000174365 E007 0.6997360 0.0167277432 0.3322104133 0.475834621 20 38446654 38446667 14 + 0.000 0.231 12.894
ENSG00000174365 E008 1.1028855 0.0118407046 0.1620169072 0.277742641 20 38446668 38446671 4 + 0.000 0.313 13.508
ENSG00000174365 E009 1.1028855 0.0118407046 0.1620169072 0.277742641 20 38446672 38446673 2 + 0.000 0.313 13.508
ENSG00000174365 E010 1.1028855 0.0118407046 0.1620169072 0.277742641 20 38446674 38446674 1 + 0.000 0.313 13.508
ENSG00000174365 E011 1.3243307 0.0108647759 0.1164812818 0.214931620 20 38446675 38446679 5 + 0.000 0.349 13.729
ENSG00000174365 E012 9.8760782 0.0017427504 0.1176095111 0.216530472 20 38446680 38446687 8 + 0.765 0.975 0.806
ENSG00000174365 E013 21.4222037 0.0009571446 0.1662748326 0.283349688 20 38446688 38446692 5 + 1.136 1.265 0.459
ENSG00000174365 E014 27.3815150 0.0007277599 0.1098583141 0.205350391 20 38446693 38446696 4 + 1.238 1.371 0.467
ENSG00000174365 E015 28.4081411 0.0006889903 0.1011648839 0.192253669 20 38446697 38446698 2 + 1.252 1.387 0.469
ENSG00000174365 E016 29.1110993 0.0006746151 0.1096754954 0.205086205 20 38446699 38446699 1 + 1.267 1.396 0.451
ENSG00000174365 E017 30.3956892 0.0006562398 0.0613155400 0.128846697 20 38446700 38446700 1 + 1.267 1.417 0.523
ENSG00000174365 E018 36.6099572 0.0005858766 0.0417696107 0.094303612 20 38446701 38446703 3 + 1.344 1.495 0.518
ENSG00000174365 E019 54.1559962 0.0004660182 0.2132669786 0.342391774 20 38446704 38446709 6 + 1.577 1.649 0.245
ENSG00000174365 E020 58.6773278 0.0004459629 0.2948793548 0.435987219 20 38446710 38446715 6 + 1.623 1.681 0.195
ENSG00000174365 E021 83.7897740 0.0005251572 0.2753974690 0.414695537 20 38446716 38446726 11 + 1.779 1.829 0.170
ENSG00000174365 E022 110.3672418 0.0003026324 0.6793640224 0.783573265 20 38446727 38446758 32 + 1.928 1.943 0.048
ENSG00000174365 E023 166.6934024 0.0003002735 0.7079184658 0.805681894 20 38446759 38446852 94 + 2.110 2.120 0.033
ENSG00000174365 E024 122.0514109 0.0002778611 0.0772772491 0.155123580 20 38446853 38446886 34 + 1.928 1.997 0.229
ENSG00000174365 E025 144.7512626 0.0002446667 0.0248526774 0.061567680 20 38446887 38446940 54 + 1.992 2.072 0.270
ENSG00000174365 E026 96.3727809 0.0002890761 0.0527974515 0.114133514 20 38446941 38446948 8 + 1.812 1.898 0.288
ENSG00000174365 E027 97.9045325 0.0002978286 0.0023188903 0.008210882 20 38446949 38446967 19 + 1.774 1.913 0.467
ENSG00000174365 E028 121.2413780 0.0002484206 0.0060791695 0.018819230 20 38446968 38447012 45 + 1.890 2.000 0.370
ENSG00000174365 E029 18.6458161 0.0010295594 0.9085415988 0.945894359 20 38447013 38447032 20 + 1.206 1.193 -0.048
ENSG00000174365 E030 23.2358611 0.0015882602 0.0833081399 0.164749180 20 38447033 38447076 44 + 1.389 1.244 -0.508
ENSG00000174365 E031 30.1580790 0.0073016556 0.0008016571 0.003265493 20 38447077 38447171 95 + 1.584 1.319 -0.913
ENSG00000174365 E032 44.7293856 0.0113761875 0.0002575999 0.001206943 20 38447172 38447313 142 + 1.757 1.484 -0.928
ENSG00000174365 E033 25.4489262 0.0077818464 0.0033262736 0.011224263 20 38447314 38447348 35 + 1.510 1.261 -0.863
ENSG00000174365 E034 39.6398415 0.0098151101 0.0399543037 0.090953281 20 38447349 38447465 117 + 1.630 1.469 -0.549
ENSG00000174365 E035 179.4344492 0.0002695794 0.3656617084 0.509979046 20 38447466 38447541 76 + 2.126 2.153 0.091
ENSG00000174365 E036 140.6971403 0.0002632700 0.5218308516 0.655700372 20 38447542 38447564 23 + 2.027 2.048 0.070
ENSG00000174365 E037 197.9311341 0.0003512134 0.3618467961 0.506249880 20 38447565 38447623 59 + 2.216 2.186 -0.101
ENSG00000174365 E038 12.7581945 0.0242815513 0.0042403045 0.013814021 20 38447624 38447929 306 + 1.295 0.951 -1.238
ENSG00000174365 E039 16.5995302 0.0052866686 0.0042714188 0.013903192 20 38447930 38448083 154 + 1.344 1.071 -0.971
ENSG00000174365 E040 7.1180263 0.0023587849 0.0110245038 0.031219121 20 38448084 38448093 10 + 1.051 0.732 -1.222
ENSG00000174365 E041 15.6592861 0.0011466662 0.0003446151 0.001558517 20 38448094 38448584 491 + 1.368 1.042 -1.156
ENSG00000174365 E042 6.4546582 0.0089556236 0.2597719931 0.397225202 20 38448585 38448661 77 + 0.916 0.758 -0.613
ENSG00000174365 E043 112.4443561 0.0004014067 0.1712507413 0.289814007 20 38448662 38448665 4 + 1.997 1.940 -0.191
ENSG00000174365 E044 206.0829897 0.0002239397 0.7885677198 0.864634174 20 38448666 38448730 65 + 2.219 2.209 -0.035
ENSG00000174365 E045 12.5316589 0.0075586604 0.0491757460 0.107689794 20 38448731 38448819 89 + 1.206 0.990 -0.780
ENSG00000174365 E046 34.9901960 0.0051031747 0.0004393683 0.001925856 20 38448820 38449368 549 + 1.647 1.394 -0.870
ENSG00000174365 E047 6.9246792 0.0023686620 0.0806617170 0.160584307 20 38449369 38449369 1 + 0.975 0.746 -0.885
ENSG00000174365 E048 20.7743759 0.0057796759 0.1416563735 0.250306630 20 38449370 38449556 187 + 1.344 1.208 -0.479
ENSG00000174365 E049 63.6950685 0.0032487507 0.0118125840 0.033086797 20 38449557 38450261 705 + 1.820 1.677 -0.486
ENSG00000174365 E050 96.4867011 0.0005147771 0.0452864831 0.100717143 20 38450262 38450335 74 + 1.955 1.868 -0.295
ENSG00000174365 E051 282.0092503 0.0001959046 0.1653452952 0.282133646 20 38450336 38450447 112 + 2.320 2.353 0.111
ENSG00000174365 E052 34.3482124 0.0006188341 0.0115661328 0.032503659 20 38450448 38450532 85 + 1.577 1.405 -0.591
ENSG00000174365 E053 373.7341829 0.0023787488 0.4489306060 0.590139586 20 38450533 38450779 247 + 2.452 2.476 0.079
ENSG00000174365 E054 139.3743231 0.0045673338 0.9768468617 0.989550076 20 38450780 38450940 161 + 2.044 2.047 0.008