ENSG00000174306

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000421422 ENSG00000174306 HEK293_OSMI2_2hA HEK293_TMG_2hB ZHX3 protein_coding protein_coding 7.608675 8.788412 5.91587 0.7036716 0.06537847 -0.5702163 2.0303052 3.01213189 0.8159820 0.37412210 0.24627462 -1.8713845 0.25714167 0.34570000 0.1371333 -0.20856667 0.021665843 0.004496489 TRUE TRUE
ENST00000432768 ENSG00000174306 HEK293_OSMI2_2hA HEK293_TMG_2hB ZHX3 protein_coding protein_coding 7.608675 8.788412 5.91587 0.7036716 0.06537847 -0.5702163 2.0352443 2.14623721 1.5074308 0.38151051 0.20217996 -0.5068851 0.26189167 0.24013333 0.2546000 0.01446667 0.943685149 0.004496489 FALSE TRUE
ENST00000559234 ENSG00000174306 HEK293_OSMI2_2hA HEK293_TMG_2hB ZHX3 protein_coding protein_coding 7.608675 8.788412 5.91587 0.7036716 0.06537847 -0.5702163 0.3571895 0.07857747 0.6988182 0.06479599 0.10144454 3.0004040 0.05216250 0.01033333 0.1179000 0.10756667 0.005128974 0.004496489 FALSE TRUE
ENST00000683867 ENSG00000174306 HEK293_OSMI2_2hA HEK293_TMG_2hB ZHX3 protein_coding protein_coding 7.608675 8.788412 5.91587 0.7036716 0.06537847 -0.5702163 1.6638791 1.04072706 1.9397900 0.52931196 0.36858868 0.8919308 0.23307917 0.12146667 0.3292667 0.20780000 0.472085903 0.004496489 FALSE TRUE
MSTRG.20721.8 ENSG00000174306 HEK293_OSMI2_2hA HEK293_TMG_2hB ZHX3 protein_coding   7.608675 8.788412 5.91587 0.7036716 0.06537847 -0.5702163 0.8029441 1.79751144 0.6058927 0.24632923 0.08367795 -1.5532538 0.09698333 0.20320000 0.1022000 -0.10100000 0.019534357 0.004496489   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000174306 E001 0.1482932 0.0414549960 6.818876e-01   20 41178448 41178454 7 - 0.000 0.105 9.402
ENSG00000174306 E002 405.1542637 0.0032880571 2.119301e-06 1.639225e-05 20 41178455 41182113 3659 - 2.499 2.641 0.476
ENSG00000174306 E003 9.5891783 0.0018049703 5.747929e-01 7.005454e-01 20 41182114 41182114 1 - 0.961 1.035 0.276
ENSG00000174306 E004 178.4894418 0.0002536290 2.152529e-04 1.029461e-03 20 41182115 41184143 2029 - 2.287 2.208 -0.267
ENSG00000174306 E005 35.0503681 0.0021141128 6.862951e-02 1.410908e-01 20 41184144 41184367 224 - 1.603 1.507 -0.328
ENSG00000174306 E006 67.5055788 0.0046877415 7.591762e-02 1.529795e-01 20 41184368 41184819 452 - 1.870 1.794 -0.256
ENSG00000174306 E007 13.9510797 0.0019249708 3.849184e-02 8.826575e-02 20 41184820 41184820 1 - 1.265 1.096 -0.602
ENSG00000174306 E008 14.9130615 0.0048161789 4.126522e-02 9.336755e-02 20 41184821 41184826 6 - 1.292 1.123 -0.598
ENSG00000174306 E009 36.0857320 0.0024488836 3.997605e-01 5.435015e-01 20 41184827 41184915 89 - 1.515 1.584 0.235
ENSG00000174306 E010 91.4609194 0.0006205099 1.582643e-05 1.004546e-04 20 41184916 41185195 280 - 1.825 2.012 0.628
ENSG00000174306 E011 23.0991265 0.0051456855 3.597902e-02 8.354005e-02 20 41185196 41185201 6 - 1.247 1.434 0.653
ENSG00000174306 E012 10.8903413 0.0019018849 2.100491e-01 3.385989e-01 20 41201286 41201384 99 - 0.961 1.106 0.533
ENSG00000174306 E013 77.3423656 0.0003911580 1.557911e-03 5.822711e-03 20 41202057 41202282 226 - 1.783 1.930 0.498
ENSG00000174306 E014 358.0725997 0.0010209168 8.814999e-01 9.280785e-01 20 41202283 41204244 1962 - 2.532 2.544 0.040
ENSG00000174306 E015 75.7119518 0.0111481688 1.092917e-02 3.099178e-02 20 41204245 41204627 383 - 1.953 1.809 -0.484
ENSG00000174306 E016 21.7200047 0.0016371391 5.805321e-02 1.233016e-01 20 41204628 41204647 20 - 1.418 1.292 -0.437
ENSG00000174306 E017 36.7626814 0.0009255896 1.401865e-03 5.313068e-03 20 41204648 41204773 126 - 1.658 1.489 -0.578
ENSG00000174306 E018 17.7663828 0.0010894967 1.922598e-02 4.982632e-02 20 41204774 41204777 4 - 1.356 1.183 -0.608
ENSG00000174306 E019 46.7384195 0.0027343951 9.218265e-05 4.852248e-04 20 41204778 41205066 289 - 1.780 1.579 -0.682
ENSG00000174306 E020 1.8412335 0.0190160812 9.209792e-01 9.541215e-01 20 41213734 41213757 24 - 0.468 0.463 -0.023
ENSG00000174306 E021 2.4347075 0.0071500437 7.133834e-01 8.098972e-01 20 41213758 41213899 142 - 0.468 0.540 0.348
ENSG00000174306 E022 1.6305838 0.1858323805 6.375624e-01 7.514265e-01 20 41238688 41238726 39 - 0.336 0.429 0.530
ENSG00000174306 E023 1.5563746 0.0227971373 8.219038e-01 8.876960e-01 20 41238727 41238796 70 - 0.406 0.375 -0.177
ENSG00000174306 E024 0.3697384 0.0251006382 3.230560e-01 4.663932e-01 20 41239598 41239704 107 - 0.000 0.190 12.435
ENSG00000174306 E025 0.1482932 0.0414549960 6.818876e-01   20 41254588 41254635 48 - 0.000 0.105 11.301
ENSG00000174306 E026 4.3921684 0.0778494907 6.575619e-01 7.668870e-01 20 41267463 41267612 150 - 0.652 0.737 0.353
ENSG00000174306 E027 5.2765087 0.0265581804 1.752677e-01 2.950206e-01 20 41268979 41268980 2 - 0.901 0.727 -0.687
ENSG00000174306 E028 5.7903756 0.0159790008 1.190022e-01 2.185147e-01 20 41268981 41268989 9 - 0.942 0.750 -0.744
ENSG00000174306 E029 24.9229048 0.0008219501 3.754167e-02 8.648432e-02 20 41268990 41269083 94 - 1.472 1.344 -0.444
ENSG00000174306 E030 0.0000000       20 41269411 41269485 75 -      
ENSG00000174306 E031 0.0000000       20 41271927 41272138 212 -      
ENSG00000174306 E032 0.0000000       20 41272139 41272203 65 -      
ENSG00000174306 E033 0.0000000       20 41272204 41272273 70 -      
ENSG00000174306 E034 0.0000000       20 41299966 41300127 162 -      
ENSG00000174306 E035 0.8846495 0.0267817168 3.379022e-01 4.817797e-01 20 41316862 41317186 325 - 0.142 0.321 1.500
ENSG00000174306 E036 8.1897896 0.0019980105 1.214374e-04 6.204745e-04 20 41317509 41317731 223 - 1.163 0.752 -1.543