ENSG00000174243

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000308025 ENSG00000174243 HEK293_OSMI2_2hA HEK293_TMG_2hB DDX23 protein_coding protein_coding 89.51361 87.56276 87.52846 4.073152 1.939884 -0.0005652646 75.43852 81.8488 68.19178 3.918602 0.4722171 -0.2633281 0.8420458 0.9346333 0.7796333 -0.155 2.067902e-24 2.067902e-24 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000174243 E001 672.7293772 0.0022668284 7.782312e-13 1.945290e-11 12 48829756 48830056 301 - 2.680 2.890 0.699
ENSG00000174243 E002 580.2450565 0.0024558878 7.200656e-10 1.097902e-08 12 48830057 48830125 69 - 2.628 2.821 0.640
ENSG00000174243 E003 796.0582484 0.0020339959 3.834977e-13 1.004458e-11 12 48830126 48830259 134 - 2.760 2.960 0.666
ENSG00000174243 E004 1180.9674361 0.0033438455 5.386016e-05 3.010280e-04 12 48830260 48830515 256 - 2.976 3.110 0.445
ENSG00000174243 E005 817.2825330 0.0014046432 1.835045e-04 8.928824e-04 12 48830516 48830692 177 - 2.842 2.939 0.322
ENSG00000174243 E006 367.2164814 0.0022607049 5.461047e-03 1.718484e-02 12 48831142 48831213 72 - 2.495 2.590 0.320
ENSG00000174243 E007 486.1256746 0.0017242628 7.541636e-03 2.262240e-02 12 48831214 48831316 103 - 2.625 2.708 0.275
ENSG00000174243 E008 10.1554265 0.0230189326 8.270565e-02 1.637841e-01 12 48831829 48832002 174 - 1.145 0.942 -0.742
ENSG00000174243 E009 6.3021302 0.0478543905 8.428475e-03 2.485909e-02 12 48832003 48832077 75 - 1.055 0.647 -1.592
ENSG00000174243 E010 562.9854302 0.0001275971 6.085970e-07 5.295163e-06 12 48832078 48832186 109 - 2.682 2.779 0.320
ENSG00000174243 E011 375.0943430 0.0002164095 2.280159e-03 8.090178e-03 12 48832422 48832450 29 - 2.519 2.596 0.255
ENSG00000174243 E012 478.3368253 0.0001135075 7.371921e-05 3.979904e-04 12 48832451 48832507 57 - 2.619 2.703 0.280
ENSG00000174243 E013 323.8579156 0.0001591475 2.384929e-04 1.126952e-03 12 48832508 48832522 15 - 2.445 2.538 0.310
ENSG00000174243 E014 465.1176833 0.0001393188 2.877307e-07 2.673093e-06 12 48832523 48832573 51 - 2.592 2.699 0.355
ENSG00000174243 E015 7.1660805 0.0087202476 8.430455e-03 2.486339e-02 12 48832574 48832915 342 - 1.070 0.767 -1.147
ENSG00000174243 E016 901.7936948 0.0001156868 1.529011e-01 2.656030e-01 12 48833277 48833519 243 - 2.925 2.960 0.114
ENSG00000174243 E017 3.6850365 0.0072982811 1.143707e-02 3.220210e-02 12 48833520 48833561 42 - 0.840 0.478 -1.564
ENSG00000174243 E018 646.4180387 0.0006863980 1.343037e-02 3.691682e-02 12 48834320 48834457 138 - 2.821 2.790 -0.104
ENSG00000174243 E019 389.0419590 0.0002033506 5.651999e-02 1.206337e-01 12 48834458 48834497 40 - 2.596 2.576 -0.066
ENSG00000174243 E020 9.3037196 0.0045953950 1.490497e-01 2.603858e-01 12 48834498 48834760 263 - 1.083 0.941 -0.524
ENSG00000174243 E021 5.0671092 0.0035698737 1.028806e-03 4.057884e-03 12 48835120 48835214 95 - 0.979 0.553 -1.726
ENSG00000174243 E022 470.4022438 0.0005843168 2.956582e-03 1.013399e-02 12 48836121 48836175 55 - 2.691 2.648 -0.145
ENSG00000174243 E023 608.8502702 0.0007145495 5.630239e-04 2.395795e-03 12 48836176 48836266 91 - 2.807 2.756 -0.169
ENSG00000174243 E024 559.7589197 0.0003395946 5.126811e-04 2.207256e-03 12 48836569 48836641 73 - 2.766 2.721 -0.148
ENSG00000174243 E025 636.0381558 0.0001091809 5.106007e-05 2.871061e-04 12 48836642 48836771 130 - 2.821 2.778 -0.143
ENSG00000174243 E026 309.6796807 0.0001796841 4.465376e-03 1.444393e-02 12 48836772 48836794 23 - 2.510 2.467 -0.143
ENSG00000174243 E027 7.3325612 0.0031902002 5.648917e-05 3.140540e-04 12 48836795 48836893 99 - 1.133 0.674 -1.761
ENSG00000174243 E028 623.2087346 0.0001808317 4.976479e-05 2.806057e-04 12 48836894 48837025 132 - 2.814 2.767 -0.154
ENSG00000174243 E029 323.9252644 0.0002381068 4.493117e-02 1.000726e-01 12 48837026 48837037 12 - 2.519 2.493 -0.085
ENSG00000174243 E030 4.7585883 0.0729854424 7.108431e-01 8.079283e-01 12 48837038 48837280 243 - 0.791 0.740 -0.205
ENSG00000174243 E031 312.7501229 0.0016433153 5.340781e-02 1.152163e-01 12 48837281 48837291 11 - 2.511 2.472 -0.131
ENSG00000174243 E032 573.4930117 0.0010642643 4.274060e-02 9.606898e-02 12 48837292 48837393 102 - 2.767 2.738 -0.098
ENSG00000174243 E033 19.4441101 0.0009635643 2.336179e-07 2.211252e-06 12 48837394 48837523 130 - 1.496 1.114 -1.339
ENSG00000174243 E034 297.0868825 0.0002018376 3.611327e-02 8.380658e-02 12 48837524 48837532 9 - 2.484 2.455 -0.095
ENSG00000174243 E035 664.0692436 0.0004958406 8.579682e-05 4.553820e-04 12 48837533 48837657 125 - 2.845 2.792 -0.176
ENSG00000174243 E036 42.2728430 0.0045897280 2.248548e-12 5.209499e-11 12 48837658 48837941 284 - 1.835 1.408 -1.456
ENSG00000174243 E037 547.8716608 0.0004138500 6.861918e-08 7.194077e-07 12 48837942 48838014 73 - 2.778 2.697 -0.268
ENSG00000174243 E038 491.2846659 0.0001629906 9.025004e-10 1.349136e-08 12 48838015 48838080 66 - 2.735 2.648 -0.288
ENSG00000174243 E039 1.1801942 0.0119138878 6.638765e-02 1.373733e-01 12 48839487 48839551 65 - 0.508 0.196 -1.960
ENSG00000174243 E040 457.8140493 0.0001927236 2.811921e-10 4.597084e-09 12 48839844 48839909 66 - 2.709 2.614 -0.314
ENSG00000174243 E041 503.8418735 0.0001457146 3.405002e-08 3.795273e-07 12 48840013 48840106 94 - 2.740 2.665 -0.248
ENSG00000174243 E042 2.6883057 0.0061260035 6.799318e-01 7.839848e-01 12 48840107 48840128 22 - 0.508 0.587 0.364
ENSG00000174243 E043 1.9467526 0.0073541187 6.133718e-01 7.320591e-01 12 48840129 48840151 23 - 0.508 0.434 -0.373
ENSG00000174243 E044 630.2139545 0.0011579560 2.631135e-06 1.994880e-05 12 48843940 48844050 111 - 2.841 2.755 -0.288
ENSG00000174243 E045 701.7023912 0.0017602474 3.410156e-07 3.119687e-06 12 48845574 48845782 209 - 2.900 2.790 -0.365
ENSG00000174243 E046 0.5964967 0.0223335361 1.952643e-01 3.203068e-01 12 48847256 48847347 92 - 0.325 0.109 -1.960
ENSG00000174243 E047 0.5964967 0.0223335361 1.952643e-01 3.203068e-01 12 48847348 48847350 3 - 0.325 0.109 -1.960
ENSG00000174243 E048 294.0163731 0.0042268202 5.397885e-04 2.309103e-03 12 48852084 48852163 80 - 2.527 2.408 -0.399
ENSG00000174243 E049 0.0000000       12 48852624 48852842 219 -