ENSG00000174238

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000313486 ENSG00000174238 HEK293_OSMI2_2hA HEK293_TMG_2hB PITPNA protein_coding protein_coding 51.16441 58.25272 55.10502 2.122997 2.530044 -0.08012747 38.471855 47.732163 37.14331 2.2788548 0.5754055 -0.3617731 0.7523500 0.81896667 0.6760000 -0.1429667 1.246786e-03 2.016618e-13 FALSE TRUE
MSTRG.13362.2 ENSG00000174238 HEK293_OSMI2_2hA HEK293_TMG_2hB PITPNA protein_coding   51.16441 58.25272 55.10502 2.122997 2.530044 -0.08012747 5.600175 4.047194 10.32294 0.2187587 0.4250636 1.3486969 0.1083333 0.06996667 0.1874667 0.1175000 2.016618e-13 2.016618e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000174238 E001 2825.3326327 0.0010334661 9.158081e-14 2.618034e-12 17 1517718 1520044 2327 - 3.369 3.488 0.397
ENSG00000174238 E002 339.4493771 0.0013765891 3.920450e-07 3.540122e-06 17 1520045 1520212 168 - 2.585 2.479 -0.355
ENSG00000174238 E003 784.6481290 0.0003393033 2.791718e-02 6.784983e-02 17 1520213 1520538 326 - 2.854 2.912 0.196
ENSG00000174238 E004 503.2036363 0.0025051098 3.143647e-02 7.475883e-02 17 1521579 1521645 67 - 2.641 2.730 0.294
ENSG00000174238 E005 514.7320148 0.0021368085 1.717906e-01 2.905433e-01 17 1534099 1534168 70 - 2.667 2.730 0.211
ENSG00000174238 E006 434.6584278 0.0020295617 6.848626e-01 7.877180e-01 17 1534169 1534221 53 - 2.623 2.639 0.052
ENSG00000174238 E007 410.0273329 0.0012248174 9.843153e-01 9.942828e-01 17 1535182 1535261 80 - 2.592 2.619 0.089
ENSG00000174238 E008 281.8933217 0.0001685441 4.624946e-01 6.023484e-01 17 1535262 1535292 31 - 2.420 2.462 0.141
ENSG00000174238 E009 305.9410128 0.0014193799 9.637886e-01 9.811381e-01 17 1535441 1535470 30 - 2.466 2.488 0.073
ENSG00000174238 E010 292.2744232 0.0027101597 7.445895e-01 8.328674e-01 17 1535471 1535506 36 - 2.452 2.463 0.037
ENSG00000174238 E011 242.5529184 0.0034328412 6.026855e-01 7.236283e-01 17 1535507 1535518 12 - 2.376 2.379 0.008
ENSG00000174238 E012 0.8867258 0.0211036047 2.763952e-01 4.158506e-01 17 1535785 1535841 57 - 0.133 0.338 1.712
ENSG00000174238 E013 3.2922911 0.0048320461 5.657415e-01 6.927942e-01 17 1538439 1538868 430 - 0.662 0.596 -0.288
ENSG00000174238 E014 351.5522578 0.0016687948 4.172140e-01 5.605847e-01 17 1538869 1538952 84 - 2.540 2.540 0.003
ENSG00000174238 E015 229.7516082 0.0015521507 1.065441e-01 2.004575e-01 17 1541566 1541586 21 - 2.370 2.346 -0.083
ENSG00000174238 E016 278.7761474 0.0015540491 1.306821e-01 2.351012e-01 17 1541587 1541640 54 - 2.450 2.430 -0.065
ENSG00000174238 E017 226.6581434 0.0020841619 3.484320e-02 8.134947e-02 17 1543020 1543027 8 - 2.375 2.330 -0.150
ENSG00000174238 E018 388.2976098 0.0001528234 1.810407e-03 6.632218e-03 17 1548296 1548387 92 - 2.602 2.571 -0.105
ENSG00000174238 E019 428.0804944 0.0003885293 5.178772e-11 9.597954e-10 17 1553004 1553149 146 - 2.682 2.583 -0.329
ENSG00000174238 E020 185.3118757 0.0025389048 1.979297e-08 2.310363e-07 17 1558529 1558559 31 - 2.358 2.184 -0.582
ENSG00000174238 E021 7.3153665 0.0234257571 3.428091e-02 8.029593e-02 17 1559508 1559755 248 - 1.044 0.781 -0.998
ENSG00000174238 E022 4.1654047 0.0094834990 1.127940e-02 3.182913e-02 17 1559756 1559801 46 - 0.874 0.526 -1.456
ENSG00000174238 E023 7.2278158 0.0023643169 1.499653e-01 2.616276e-01 17 1561199 1561281 83 - 0.984 0.838 -0.551
ENSG00000174238 E024 174.0895852 0.0052689085 7.512009e-16 2.885498e-14 17 1562541 1562655 115 - 2.403 2.067 -1.121
ENSG00000174238 E025 66.3365485 0.0015082715 1.819586e-63 2.039734e-60 17 1562656 1562812 157 - 2.131 1.278 -2.900