ENSG00000174231

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000304992 ENSG00000174231 HEK293_OSMI2_2hA HEK293_TMG_2hB PRPF8 protein_coding protein_coding 247.677 395.8368 165.7542 45.21407 2.328547 -1.25581 163.42588 183.22108 138.08006187 19.64165 1.56187365 -0.4080547 0.72630417 0.4873333 0.8332666667 0.3459333 8.865558e-03 4.371599e-11 FALSE TRUE
ENST00000571958 ENSG00000174231 HEK293_OSMI2_2hA HEK293_TMG_2hB PRPF8 protein_coding protein_coding 247.677 395.8368 165.7542 45.21407 2.328547 -1.25581 28.17189 81.74298 0.13670342 19.73310 0.13670342 -9.1222251 0.07352917 0.2006333 0.0008333333 -0.1998000 1.489928e-05 4.371599e-11 FALSE FALSE
ENST00000572723 ENSG00000174231 HEK293_OSMI2_2hA HEK293_TMG_2hB PRPF8 protein_coding retained_intron 247.677 395.8368 165.7542 45.21407 2.328547 -1.25581 21.96734 68.98543 2.57263835 27.40176 0.47232459 -4.7395832 0.06122917 0.1623667 0.0155000000 -0.1468667 6.932069e-04 4.371599e-11 FALSE FALSE
ENST00000575116 ENSG00000174231 HEK293_OSMI2_2hA HEK293_TMG_2hB PRPF8 protein_coding processed_transcript 247.677 395.8368 165.7542 45.21407 2.328547 -1.25581 12.49223 47.95669 0.07855356 20.08081 0.07855356 -9.0812669 0.03260000 0.1122667 0.0004666667 -0.1118000 7.389318e-05 4.371599e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000174231 E001 6.0761783 0.0132851807 5.193136e-08 5.581347e-07 17 1650629 1650629 1 - 0.000 0.996 14.141
ENSG00000174231 E002 8.8858225 0.0210415195 1.598346e-04 7.911424e-04 17 1650630 1650630 1 - 0.543 1.102 2.229
ENSG00000174231 E003 2531.3699488 0.0128543762 1.172887e-13 3.301633e-12 17 1650631 1650839 209 - 3.060 3.482 1.402
ENSG00000174231 E004 1357.8921575 0.0116869765 2.091391e-15 7.574224e-14 17 1650840 1650846 7 - 2.774 3.214 1.464
ENSG00000174231 E005 3128.1105086 0.0122958522 3.784395e-13 9.917587e-12 17 1650847 1650956 110 - 3.170 3.570 1.328
ENSG00000174231 E006 4262.1843835 0.0101472039 3.140999e-11 6.026462e-10 17 1651108 1651310 203 - 3.365 3.691 1.081
ENSG00000174231 E007 2849.7968463 0.0084455699 2.787877e-11 5.400358e-10 17 1651414 1651553 140 - 3.208 3.511 1.008
ENSG00000174231 E008 1284.9491608 0.0061218972 1.504792e-13 4.169641e-12 17 1651648 1651662 15 - 2.866 3.165 0.994
ENSG00000174231 E009 2279.3365080 0.0047748604 1.723558e-16 7.203239e-15 17 1651663 1651788 126 - 3.124 3.411 0.956
ENSG00000174231 E010 16.9529501 0.0013414498 2.770725e-04 1.286312e-03 17 1651789 1651980 192 - 1.406 1.105 -1.058
ENSG00000174231 E011 7.7887007 0.0022741281 5.133888e-04 2.209686e-03 17 1651981 1652037 57 - 1.142 0.748 -1.483
ENSG00000174231 E012 7.9296321 0.0021021200 2.241311e-03 7.971045e-03 17 1652038 1652146 109 - 1.128 0.786 -1.284
ENSG00000174231 E013 39.6976524 0.0507029740 3.809618e-04 1.701088e-03 17 1652731 1653541 811 - 1.818 1.381 -1.491
ENSG00000174231 E014 2649.0545938 0.0036166791 7.701699e-13 1.926157e-11 17 1653542 1653683 142 - 3.245 3.461 0.718
ENSG00000174231 E015 3830.3311529 0.0028215848 1.008973e-11 2.099593e-10 17 1653777 1654016 240 - 3.434 3.611 0.590
ENSG00000174231 E016 12.6072338 0.0026588818 2.861088e-06 2.150891e-05 17 1654017 1654980 964 - 1.353 0.911 -1.593
ENSG00000174231 E017 3219.6357968 0.0017027014 1.709947e-09 2.426913e-08 17 1655350 1655543 194 - 3.397 3.522 0.416
ENSG00000174231 E018 2607.8677460 0.0009101880 2.014023e-11 3.989028e-10 17 1656392 1656565 174 - 3.317 3.426 0.361
ENSG00000174231 E019 1978.3032038 0.0004255270 4.239799e-11 7.962106e-10 17 1656648 1656761 114 - 3.213 3.298 0.283
ENSG00000174231 E020 2244.2411224 0.0008498627 2.053694e-03 7.392761e-03 17 1658253 1658381 129 - 3.293 3.342 0.163
ENSG00000174231 E021 2958.8465790 0.0006219553 9.610498e-02 1.845252e-01 17 1658526 1658763 238 - 3.432 3.453 0.073
ENSG00000174231 E022 1886.2393982 0.0006010479 8.173884e-02 1.622822e-01 17 1659357 1659463 107 - 3.234 3.259 0.081
ENSG00000174231 E023 1506.4785831 0.0001431537 7.035888e-05 3.818293e-04 17 1659464 1659548 85 - 3.124 3.166 0.141
ENSG00000174231 E024 41.4161321 0.0035181076 4.659777e-15 1.610326e-13 17 1659549 1659840 292 - 1.854 1.372 -1.644
ENSG00000174231 E025 1725.0468211 0.0003374184 4.587123e-04 2.001420e-03 17 1659841 1659968 128 - 3.183 3.226 0.144
ENSG00000174231 E026 1028.6840099 0.0006359756 3.793767e-01 5.236407e-01 17 1659969 1660001 33 - 2.978 2.992 0.047
ENSG00000174231 E027 1728.1952374 0.0010478550 2.934538e-01 4.345143e-01 17 1660432 1660578 147 - 3.200 3.220 0.065
ENSG00000174231 E028 1735.0527933 0.0018091575 4.346335e-01 5.769501e-01 17 1660698 1660827 130 - 3.226 3.209 -0.054
ENSG00000174231 E029 10.8999020 0.0026524867 1.248422e-02 3.469738e-02 17 1660927 1660992 66 - 1.202 0.950 -0.914
ENSG00000174231 E030 1995.6125038 0.0013054528 1.650635e-01 2.817792e-01 17 1660993 1661162 170 - 3.293 3.267 -0.087
ENSG00000174231 E031 8.1466242 0.0127027586 1.997178e-03 7.217018e-03 17 1661163 1661270 108 - 1.154 0.785 -1.381
ENSG00000174231 E032 1908.0973582 0.0014973558 8.274260e-04 3.357466e-03 17 1661271 1661406 136 - 3.300 3.232 -0.229
ENSG00000174231 E033 2032.1716977 0.0010730697 5.286732e-08 5.670680e-07 17 1661611 1661790 180 - 3.345 3.248 -0.321
ENSG00000174231 E034 1983.9232864 0.0027324098 1.461068e-03 5.510331e-03 17 1661906 1662153 248 - 3.326 3.244 -0.275
ENSG00000174231 E035 0.3030308 0.3580259869 1.645973e-01   17 1672941 1673080 140 - 0.263 0.000 -11.705
ENSG00000174231 E036 1023.1233283 0.0052317329 2.937837e-01 4.348296e-01 17 1673081 1673197 117 - 3.008 2.974 -0.115
ENSG00000174231 E037 1299.1068099 0.0057447659 2.268585e-03 8.055341e-03 17 1673357 1673567 211 - 3.161 3.048 -0.375
ENSG00000174231 E038 1029.8844469 0.0046243953 4.711340e-05 2.671503e-04 17 1673746 1673892 147 - 3.076 2.936 -0.466
ENSG00000174231 E039 897.6596952 0.0047900305 3.819744e-05 2.212557e-04 17 1674442 1674537 96 - 3.020 2.874 -0.485
ENSG00000174231 E040 952.0355530 0.0048232521 1.633748e-05 1.033822e-04 17 1674538 1674643 106 - 3.049 2.897 -0.505
ENSG00000174231 E041 634.5748226 0.0045819994 9.211374e-09 1.143312e-07 17 1674644 1674680 37 - 2.903 2.698 -0.684
ENSG00000174231 E042 1299.0424782 0.0080096598 7.131354e-06 4.900303e-05 17 1675152 1675339 188 - 3.209 3.013 -0.651
ENSG00000174231 E043 5.1348766 0.0035269531 7.918533e-05 4.240332e-04 17 1675340 1675530 191 - 1.039 0.518 -2.114
ENSG00000174231 E044 1201.9168346 0.0081545494 3.248243e-06 2.411986e-05 17 1675620 1675812 193 - 3.180 2.975 -0.681
ENSG00000174231 E045 950.8675104 0.0054708249 5.830792e-09 7.524188e-08 17 1675928 1676054 127 - 3.086 2.868 -0.726
ENSG00000174231 E046 741.3720452 0.0053326099 6.647710e-08 6.989615e-07 17 1676207 1676307 101 - 2.970 2.767 -0.675
ENSG00000174231 E047 687.9458698 0.0073735417 5.226521e-07 4.605343e-06 17 1676308 1676370 63 - 2.946 2.727 -0.726
ENSG00000174231 E048 1098.6133926 0.0105333017 4.522786e-06 3.252460e-05 17 1676505 1676711 207 - 3.154 2.926 -0.759
ENSG00000174231 E049 1155.2784278 0.0101151426 4.976632e-06 3.543725e-05 17 1676976 1677172 197 - 3.173 2.950 -0.739
ENSG00000174231 E050 2.8379378 0.0052548612 1.053918e-04 5.468851e-04 17 1677173 1677271 99 - 0.858 0.247 -3.019
ENSG00000174231 E051 917.1280784 0.0100784311 1.923911e-06 1.501892e-05 17 1677565 1677694 130 - 3.079 2.845 -0.778
ENSG00000174231 E052 6.5042387 0.0025065336 1.527586e-07 1.497292e-06 17 1678441 1678517 77 - 1.167 0.518 -2.573
ENSG00000174231 E053 990.3510556 0.0144490860 1.689687e-06 1.335612e-05 17 1678518 1678652 135 - 3.134 2.858 -0.919
ENSG00000174231 E054 804.9127060 0.0216489494 5.009120e-05 2.822950e-04 17 1678762 1678872 111 - 3.046 2.766 -0.933
ENSG00000174231 E055 348.6505214 0.0235071870 9.965064e-05 5.201839e-04 17 1678873 1678881 9 - 2.686 2.401 -0.950
ENSG00000174231 E056 992.0851930 0.0190624518 1.056316e-05 6.982410e-05 17 1679017 1679206 190 - 3.141 2.853 -0.960
ENSG00000174231 E057 755.9729859 0.0130539131 1.799075e-07 1.739991e-06 17 1679291 1679410 120 - 3.025 2.733 -0.970
ENSG00000174231 E058 1109.5981210 0.0116367485 1.495737e-10 2.561587e-09 17 1679609 1679799 191 - 3.214 2.876 -1.123
ENSG00000174231 E059 2.9284810 0.3690915031 4.176417e-02 9.429915e-02 17 1680481 1680725 245 - 0.880 0.252 -3.067
ENSG00000174231 E060 904.5379682 0.0147382008 1.565043e-09 2.239371e-08 17 1680726 1680831 106 - 3.134 2.777 -1.189
ENSG00000174231 E061 893.5648577 0.0175774457 1.471720e-08 1.758851e-07 17 1680929 1681054 126 - 3.132 2.768 -1.211
ENSG00000174231 E062 1042.7068061 0.0167866414 2.757090e-09 3.770737e-08 17 1681478 1681690 213 - 3.203 2.830 -1.243
ENSG00000174231 E063 1090.0116636 0.0177164136 4.104555e-10 6.533868e-09 17 1681820 1682038 219 - 3.236 2.833 -1.340
ENSG00000174231 E064 934.2311084 0.0173762273 1.498250e-10 2.565427e-09 17 1682129 1682293 165 - 3.172 2.761 -1.367
ENSG00000174231 E065 0.5159433 0.1970305433 3.911605e-01 5.350985e-01 17 1683021 1683532 512 - 0.262 0.100 -1.678
ENSG00000174231 E066 939.6229047 0.0186924251 1.033424e-08 1.270138e-07 17 1683533 1683701 169 - 3.160 2.782 -1.259
ENSG00000174231 E067 568.9259842 0.0253212417 2.172724e-06 1.676439e-05 17 1684472 1684582 111 - 2.935 2.573 -1.206
ENSG00000174231 E068 46.2921190 0.0062138632 2.326288e-12 5.376459e-11 17 1684583 1684779 197 - 1.890 1.439 -1.535
ENSG00000174231 E069 333.2667682 0.0242198854 3.887395e-06 2.835356e-05 17 1684780 1684984 205 - 2.699 2.346 -1.178