ENSG00000174227

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000310340 ENSG00000174227 HEK293_OSMI2_2hA HEK293_TMG_2hB PIGG protein_coding protein_coding 26.74215 19.55444 23.07203 0.9512694 1.427889 0.2385368 1.463901 0.9915779 1.813344 0.2338832 0.57168375 0.8643125 0.05663333 0.05010000 0.07613333 0.026033333 0.651351131 5.803073e-12 FALSE TRUE
ENST00000453061 ENSG00000174227 HEK293_OSMI2_2hA HEK293_TMG_2hB PIGG protein_coding protein_coding 26.74215 19.55444 23.07203 0.9512694 1.427889 0.2385368 5.843022 5.4984745 4.562289 0.9369566 0.74566084 -0.2687363 0.22757500 0.28133333 0.20280000 -0.078533333 0.579273017 5.803073e-12 FALSE TRUE
ENST00000503111 ENSG00000174227 HEK293_OSMI2_2hA HEK293_TMG_2hB PIGG protein_coding protein_coding 26.74215 19.55444 23.07203 0.9512694 1.427889 0.2385368 1.392298 1.1943106 1.485384 0.1243677 0.02032654 0.3123084 0.05275833 0.06183333 0.06480000 0.002966667 0.919853508 5.803073e-12 FALSE TRUE
ENST00000504346 ENSG00000174227 HEK293_OSMI2_2hA HEK293_TMG_2hB PIGG protein_coding protein_coding 26.74215 19.55444 23.07203 0.9512694 1.427889 0.2385368 2.256516 3.3095723 1.137702 0.6841578 0.23035341 -1.5322492 0.08750833 0.17210000 0.04880000 -0.123300000 0.008102052 5.803073e-12 FALSE TRUE
ENST00000513239 ENSG00000174227 HEK293_OSMI2_2hA HEK293_TMG_2hB PIGG protein_coding retained_intron 26.74215 19.55444 23.07203 0.9512694 1.427889 0.2385368 1.712532 1.1287143 1.508076 0.1045480 0.17318066 0.4148378 0.06237083 0.05830000 0.06500000 0.006700000 0.823121657 5.803073e-12   FALSE
MSTRG.24410.10 ENSG00000174227 HEK293_OSMI2_2hA HEK293_TMG_2hB PIGG protein_coding   26.74215 19.55444 23.07203 0.9512694 1.427889 0.2385368 5.085700 1.0450605 4.794198 1.0450605 0.94810170 2.1869699 0.17891250 0.05200000 0.20436667 0.152366667 0.113780423 5.803073e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000174227 E001 0.1817044 0.0398193304 5.427336e-01   4 499210 499220 11 + 0.000 0.116 9.638
ENSG00000174227 E002 1.4663855 0.0119651774 2.370274e-01 3.707348e-01 4 499221 499236 16 + 0.488 0.283 -1.179
ENSG00000174227 E003 1.9103227 0.0080674562 4.942004e-02 1.081280e-01 4 499237 499239 3 + 0.615 0.283 -1.764
ENSG00000174227 E004 2.3499934 0.0083444013 9.339804e-03 2.713135e-02 4 499240 499242 3 + 0.712 0.283 -2.179
ENSG00000174227 E005 3.9031483 0.0040074113 3.228725e-03 1.094069e-02 4 499243 499251 9 + 0.880 0.452 -1.843
ENSG00000174227 E006 6.8611874 0.0024149404 3.646133e-02 8.446326e-02 4 499252 499257 6 + 1.015 0.770 -0.935
ENSG00000174227 E007 30.3798755 0.0135802396 1.010143e-01 1.920080e-01 4 499258 499288 31 + 1.564 1.424 -0.482
ENSG00000174227 E008 32.9972324 0.0120286565 1.481503e-01 2.591635e-01 4 499289 499298 10 + 1.588 1.471 -0.403
ENSG00000174227 E009 46.9341895 0.0092941265 1.352482e-01 2.414584e-01 4 499299 499353 55 + 1.730 1.625 -0.354
ENSG00000174227 E010 76.5508556 0.0025072125 1.290265e-05 8.352814e-05 4 499354 499489 136 + 1.988 1.787 -0.676
ENSG00000174227 E011 7.8177543 0.0021553158 4.584088e-01 5.987297e-01 4 499490 499585 96 + 0.985 0.905 -0.301
ENSG00000174227 E012 2.8943528 0.0691317650 3.636395e-01 5.080662e-01 4 499586 499588 3 + 0.683 0.531 -0.670
ENSG00000174227 E013 4.6260030 0.0535222546 3.301680e-01 4.737545e-01 4 499589 499614 26 + 0.839 0.690 -0.596
ENSG00000174227 E014 10.6876928 0.0016344134 3.650485e-01 5.093863e-01 4 499615 499725 111 + 1.118 1.032 -0.311
ENSG00000174227 E015 1.2051864 0.0839671272 1.445754e-01 2.542503e-01 4 499726 500047 322 + 0.488 0.207 -1.768
ENSG00000174227 E016 72.6668226 0.0011558453 1.771587e-05 1.111772e-04 4 500396 500461 66 + 1.959 1.776 -0.618
ENSG00000174227 E017 125.7073237 0.0002865590 2.023825e-08 2.357400e-07 4 500462 500601 140 + 2.190 2.017 -0.579
ENSG00000174227 E018 4.2481220 0.0285604270 2.613450e-02 6.421580e-02 4 501101 501170 70 + 0.880 0.537 -1.429
ENSG00000174227 E019 0.1515154 0.0427123653 4.374127e-01   4 501171 501171 1 + 0.129 0.000 -12.998
ENSG00000174227 E020 2.9109880 0.0056812758 3.089412e-02 7.371096e-02 4 501597 502329 733 + 0.741 0.403 -1.558
ENSG00000174227 E021 152.1954064 0.0002273675 2.500455e-04 1.175414e-03 4 505718 505927 210 + 2.238 2.138 -0.335
ENSG00000174227 E022 0.2965864 0.0971497154 2.620977e-01   4 506761 506866 106 + 0.000 0.205 12.834
ENSG00000174227 E023 143.9056405 0.0002864526 9.842269e-03 2.837559e-02 4 507405 507593 189 + 2.200 2.129 -0.240
ENSG00000174227 E024 146.2645866 0.0002589598 3.542022e-03 1.184574e-02 4 508829 508970 142 + 2.211 2.130 -0.271
ENSG00000174227 E025 133.2913005 0.0028103178 5.614830e-01 6.892907e-01 4 515973 516069 97 + 2.136 2.114 -0.076
ENSG00000174227 E026 140.5629367 0.0003447436 8.176986e-01 8.847234e-01 4 516070 516185 116 + 2.140 2.151 0.035
ENSG00000174227 E027 0.9587596 0.0129180319 5.156148e-01 6.502616e-01 4 521051 521055 5 + 0.229 0.347 0.818
ENSG00000174227 E028 160.1634763 0.0003098543 2.091348e-01 3.374956e-01 4 521056 521227 172 + 2.184 2.224 0.133
ENSG00000174227 E029 67.2749409 0.0012913791 6.132542e-01 7.319987e-01 4 521228 521249 22 + 1.847 1.829 -0.061
ENSG00000174227 E030 66.9040003 0.0053644607 6.299903e-01 7.452606e-01 4 521250 521273 24 + 1.814 1.848 0.117
ENSG00000174227 E031 127.8279107 0.0072851060 5.588512e-01 6.870344e-01 4 521660 521756 97 + 2.087 2.126 0.130
ENSG00000174227 E032 124.4765067 0.0018819797 2.406311e-01 3.749067e-01 4 521757 521852 96 + 2.071 2.119 0.162
ENSG00000174227 E033 89.7632955 0.0003347731 6.130424e-01 7.318428e-01 4 521853 521889 37 + 1.964 1.949 -0.050
ENSG00000174227 E034 84.4311714 0.0003494699 6.600412e-01 7.687469e-01 4 521890 521941 52 + 1.918 1.939 0.070
ENSG00000174227 E035 16.2887935 0.0281943142 9.217028e-01 9.545958e-01 4 521942 521988 47 + 1.220 1.237 0.060
ENSG00000174227 E036 12.3372619 0.0189597523 6.058024e-01 7.261136e-01 4 521989 522007 19 + 1.082 1.149 0.240
ENSG00000174227 E037 13.3352193 0.0013606252 8.692499e-02 1.704729e-01 4 522008 522026 19 + 1.057 1.220 0.584
ENSG00000174227 E038 61.0454643 0.0047865105 8.357366e-02 1.651381e-01 4 522027 522843 817 + 1.730 1.832 0.344
ENSG00000174227 E039 81.4684635 0.0003673711 8.379876e-01 8.987090e-01 4 523459 523519 61 + 1.907 1.919 0.040
ENSG00000174227 E040 123.6136678 0.0010090849 2.567480e-01 3.937293e-01 4 523520 523651 132 + 2.067 2.109 0.139
ENSG00000174227 E041 147.2553483 0.0002356508 2.131973e-02 5.426264e-02 4 523652 523831 180 + 2.127 2.199 0.239
ENSG00000174227 E042 98.1074997 0.0004247161 1.176769e-01 2.166314e-01 4 523832 523913 82 + 1.959 2.020 0.205
ENSG00000174227 E043 9.5493026 0.0018260189 7.028851e-01 8.016445e-01 4 524560 525170 611 + 1.043 1.007 -0.132
ENSG00000174227 E044 3.8112556 0.0155366478 4.843458e-01 6.223699e-01 4 525171 525196 26 + 0.741 0.639 -0.426
ENSG00000174227 E045 6.8043017 0.0025379199 8.595219e-01 9.133759e-01 4 525365 525567 203 + 0.880 0.905 0.094
ENSG00000174227 E046 3.8780915 0.0069350505 5.888935e-01 7.120325e-01 4 525568 525634 67 + 0.741 0.668 -0.300
ENSG00000174227 E047 3.9385671 0.0044377359 1.178729e-01 2.168817e-01 4 525635 525837 203 + 0.535 0.770 1.013
ENSG00000174227 E048 1.5468227 0.0090457631 4.224377e-01 5.655759e-01 4 526950 527038 89 + 0.309 0.453 0.820
ENSG00000174227 E049 132.7449619 0.0054786299 1.840862e-01 3.063581e-01 4 527039 527230 192 + 2.085 2.148 0.211
ENSG00000174227 E050 8.3975147 0.0034025903 1.212769e-01 2.217438e-01 4 527231 527540 310 + 1.057 0.888 -0.628
ENSG00000174227 E051 202.0901041 0.0053063618 8.151871e-02 1.619237e-01 4 530436 530745 310 + 2.260 2.334 0.248
ENSG00000174227 E052 52.2228669 0.0123695863 9.149676e-02 1.774636e-01 4 530840 532113 1274 + 1.785 1.665 -0.406
ENSG00000174227 E053 35.2771457 0.0063419545 5.620218e-02 1.200565e-01 4 532114 532713 600 + 1.626 1.495 -0.448
ENSG00000174227 E054 14.8464851 0.0593384988 5.975129e-01 7.192501e-01 4 532714 532820 107 + 1.254 1.143 -0.394
ENSG00000174227 E055 17.6230338 0.0281309009 4.239502e-01 5.669706e-01 4 532821 533100 280 + 1.317 1.215 -0.357
ENSG00000174227 E056 13.6944815 0.0261462933 4.721825e-01 6.112389e-01 4 533101 533218 118 + 1.202 1.116 -0.305
ENSG00000174227 E057 25.8803494 0.0058860873 1.026327e-01 1.945162e-01 4 533219 533631 413 + 1.489 1.368 -0.417
ENSG00000174227 E058 16.4494971 0.0103115169 7.551109e-01 8.405418e-01 4 533632 533817 186 + 1.220 1.256 0.127
ENSG00000174227 E059 174.4598298 0.0006488844 1.319790e-07 1.310294e-06 4 533818 533981 164 + 2.147 2.305 0.528
ENSG00000174227 E060 6.8871085 0.0032739645 1.860859e-01 3.088450e-01 4 536259 536314 56 + 0.969 0.813 -0.594
ENSG00000174227 E061 14.6871016 0.0012329399 2.482418e-01 3.838583e-01 4 536705 536988 284 + 1.129 1.235 0.377
ENSG00000174227 E062 5.5617681 0.0030840261 7.007194e-01 8.001325e-01 4 537291 537363 73 + 0.838 0.792 -0.180
ENSG00000174227 E063 222.3955854 0.0007797181 2.857114e-16 1.162026e-14 4 539153 540200 1048 + 2.203 2.429 0.754