ENSG00000174206

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000311915 ENSG00000174206 HEK293_OSMI2_2hA HEK293_TMG_2hB KICS2 protein_coding protein_coding 4.184356 3.970764 5.713902 0.5860107 0.2323857 0.5239538 1.0744572 0.9694253 1.3575083 0.16720006 0.19855680 0.4815422 0.2631542 0.2488333 0.24076667 -0.008066667 0.98227444 0.02222643 FALSE TRUE
ENST00000398055 ENSG00000174206 HEK293_OSMI2_2hA HEK293_TMG_2hB KICS2 protein_coding protein_coding 4.184356 3.970764 5.713902 0.5860107 0.2323857 0.5239538 1.0939193 0.8654750 1.8226069 0.05054127 0.14055567 1.0657594 0.2553750 0.2254333 0.31850000 0.093066667 0.18168933 0.02222643 FALSE TRUE
ENST00000544871 ENSG00000174206 HEK293_OSMI2_2hA HEK293_TMG_2hB KICS2 protein_coding protein_coding 4.184356 3.970764 5.713902 0.5860107 0.2323857 0.5239538 1.1090730 0.9253186 1.4367464 0.35086846 0.19653479 0.6292822 0.2571208 0.2193333 0.25086667 0.031533333 0.87257248 0.02222643 FALSE TRUE
ENST00000615991 ENSG00000174206 HEK293_OSMI2_2hA HEK293_TMG_2hB KICS2 protein_coding processed_transcript 4.184356 3.970764 5.713902 0.5860107 0.2323857 0.5239538 0.6007083 0.9694926 0.4146569 0.26214984 0.09960687 -1.2057369 0.1571292 0.2477333 0.07163333 -0.176100000 0.02222643 0.02222643 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000174206 E001 38.3346814 0.0214766280 0.03110699 0.07411418 12 64186316 64187307 992 - 1.500 1.690 0.648
ENSG00000174206 E002 22.2274338 0.0280116346 0.61801638 0.73575450 12 64187308 64187652 345 - 1.332 1.414 0.282
ENSG00000174206 E003 50.9858033 0.0010236038 0.05704855 0.12154660 12 64191080 64192638 1559 - 1.749 1.670 -0.267
ENSG00000174206 E004 96.4506483 0.0025496101 0.33944064 0.48336211 12 64192639 64193838 1200 - 1.971 2.022 0.170
ENSG00000174206 E005 15.4029953 0.0013508828 0.72785744 0.82044266 12 64193839 64193846 8 - 1.223 1.207 -0.054
ENSG00000174206 E006 107.1032403 0.0003315506 0.01018520 0.02922064 12 64193847 64194658 812 - 2.064 2.002 -0.209
ENSG00000174206 E007 39.1844745 0.0006970769 0.04965438 0.10854669 12 64215678 64215963 286 - 1.644 1.552 -0.316
ENSG00000174206 E008 0.5827671 0.0990553061 0.10554777 0.19893259 12 64221497 64221698 202 - 0.314 0.000 -10.631
ENSG00000174206 E009 4.1181715 0.0041555713 0.13184352 0.23668267 12 64221699 64221901 203 - 0.594 0.818 0.930
ENSG00000174206 E010 4.1117532 0.0221935543 0.03006555 0.07208084 12 64221902 64222002 101 - 0.531 0.867 1.409
ENSG00000174206 E011 24.8595409 0.0237271586 0.67324862 0.77898122 12 64222003 64222161 159 - 1.396 1.438 0.144
ENSG00000174206 E012 14.3214846 0.0201756748 0.22656851 0.35831343 12 64222162 64222296 135 - 1.122 1.256 0.479