ENSG00000174177

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000312060 ENSG00000174177 HEK293_OSMI2_2hA HEK293_TMG_2hB CTU2 protein_coding protein_coding 64.7427 104.6728 34.39397 7.044111 1.422077 -1.605378 9.332883 13.573165 7.082428 3.0953917 0.67766437 -0.9374681 0.15435417 0.12680000 0.2057333 0.07893333 0.143485823 2.637845e-08 FALSE TRUE
ENST00000453996 ENSG00000174177 HEK293_OSMI2_2hA HEK293_TMG_2hB CTU2 protein_coding protein_coding 64.7427 104.6728 34.39397 7.044111 1.422077 -1.605378 39.754263 71.644780 16.841582 0.9527769 0.27481581 -2.0881789 0.58101667 0.68956667 0.4912667 -0.19830000 0.005514061 2.637845e-08 FALSE TRUE
ENST00000567316 ENSG00000174177 HEK293_OSMI2_2hA HEK293_TMG_2hB CTU2 protein_coding protein_coding 64.7427 104.6728 34.39397 7.044111 1.422077 -1.605378 4.173553 4.927402 2.533542 0.8711658 0.07222656 -0.9569130 0.07278333 0.04706667 0.0738000 0.02673333 0.147265599 2.637845e-08 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000174177 E001 0.8513531 0.0179775972 6.582286e-02 1.364088e-01 16 88706465 88706481 17 + 0.460 0.127 -2.473
ENSG00000174177 E002 2.2466604 0.0068172637 1.694566e-01 2.874839e-01 16 88706482 88706482 1 + 0.617 0.371 -1.214
ENSG00000174177 E003 26.8922068 0.0625539265 2.139910e-01 3.432418e-01 16 88706483 88706502 20 + 1.455 1.298 -0.546
ENSG00000174177 E004 108.0136801 0.0111996657 1.550427e-02 4.163933e-02 16 88706503 88706517 15 + 2.042 1.889 -0.512
ENSG00000174177 E005 156.6395706 0.0054629548 5.791288e-03 1.806521e-02 16 88706518 88706521 4 + 2.186 2.053 -0.444
ENSG00000174177 E006 223.6826275 0.0039833070 1.048781e-02 2.994957e-02 16 88706522 88706544 23 + 2.318 2.214 -0.349
ENSG00000174177 E007 321.5449480 0.0020723062 1.158785e-03 4.501204e-03 16 88706545 88706588 44 + 2.475 2.371 -0.349
ENSG00000174177 E008 278.1523801 0.0031834183 2.345461e-02 5.869213e-02 16 88706589 88706598 10 + 2.398 2.313 -0.283
ENSG00000174177 E009 9.8378940 0.0203725284 5.026850e-03 1.600568e-02 16 88706599 88707135 537 + 1.188 0.833 -1.314
ENSG00000174177 E010 398.8674652 0.0031281907 1.117919e-02 3.159406e-02 16 88707136 88707210 75 + 2.555 2.470 -0.284
ENSG00000174177 E011 290.1891881 0.0022683986 4.353251e-02 9.752269e-02 16 88709938 88709958 21 + 2.407 2.336 -0.237
ENSG00000174177 E012 369.5311600 0.0002650127 8.712566e-03 2.556803e-02 16 88709959 88710016 58 + 2.505 2.439 -0.221
ENSG00000174177 E013 386.6951494 0.0004256685 8.423610e-02 1.661957e-01 16 88710223 88710282 60 + 2.508 2.462 -0.153
ENSG00000174177 E014 6.9147461 0.0392248621 3.704781e-07 3.363652e-06 16 88710283 88710908 626 + 1.269 0.532 -2.873
ENSG00000174177 E015 422.3911948 0.0001595821 2.182298e-01 3.482717e-01 16 88711635 88711695 61 + 2.536 2.504 -0.107
ENSG00000174177 E016 24.8289292 0.0022263797 2.119045e-06 1.639093e-05 16 88712061 88712273 213 + 1.573 1.205 -1.274
ENSG00000174177 E017 532.9726921 0.0001623264 1.639747e-01 2.803132e-01 16 88712274 88712383 110 + 2.637 2.605 -0.108
ENSG00000174177 E018 764.7713559 0.0001151722 6.652113e-02 1.375894e-01 16 88712622 88712905 284 + 2.747 2.771 0.081
ENSG00000174177 E019 589.3959731 0.0001132539 1.912297e-01 3.152774e-01 16 88713312 88713447 136 + 2.638 2.657 0.061
ENSG00000174177 E020 9.6302132 0.0249696075 7.655210e-03 2.291410e-02 16 88713480 88713646 167 + 1.170 0.824 -1.285
ENSG00000174177 E021 631.9839197 0.0003323294 2.955460e-02 7.108346e-02 16 88713647 88713778 132 + 2.655 2.692 0.124
ENSG00000174177 E022 526.9989817 0.0001479514 2.567524e-03 8.965416e-03 16 88714136 88714227 92 + 2.561 2.616 0.182
ENSG00000174177 E023 517.2929164 0.0001771618 4.443709e-03 1.438170e-02 16 88714383 88714486 104 + 2.555 2.608 0.174
ENSG00000174177 E024 16.2575239 0.0186382257 8.293510e-03 2.452709e-02 16 88714487 88714586 100 + 1.348 1.052 -1.054
ENSG00000174177 E025 523.1329274 0.0004404374 2.467384e-04 1.161771e-03 16 88714587 88714681 95 + 2.541 2.617 0.252
ENSG00000174177 E026 362.2223274 0.0001483755 1.041298e-04 5.410907e-04 16 88714682 88714737 56 + 2.369 2.458 0.298
ENSG00000174177 E027 379.5280440 0.0004619469 1.612735e-04 7.974812e-04 16 88714860 88714926 67 + 2.389 2.480 0.304
ENSG00000174177 E028 19.4208368 0.0147576408 2.895613e-02 6.992099e-02 16 88714985 88715047 63 + 1.373 1.148 -0.790
ENSG00000174177 E029 338.3883146 0.0053111326 9.842189e-03 2.837559e-02 16 88715048 88715106 59 + 2.326 2.437 0.369
ENSG00000174177 E030 33.3745025 0.0051396932 2.555934e-02 6.303843e-02 16 88715107 88715181 75 + 1.558 1.384 -0.597
ENSG00000174177 E031 416.8348032 0.0042624761 8.478296e-03 2.498153e-02 16 88715182 88715396 215 + 2.425 2.525 0.333