ENSG00000174151

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000310611 ENSG00000174151 HEK293_OSMI2_2hA HEK293_TMG_2hB CYB561D1 protein_coding protein_coding 4.986129 6.624643 3.711262 0.343984 0.03258316 -0.8342268 1.0993465 1.5142706 1.3631048 0.2632769 0.60828654 -0.15067730 0.23347917 0.22583333 0.36526667 0.13943333 0.73451434 0.01281376 FALSE FALSE
ENST00000393709 ENSG00000174151 HEK293_OSMI2_2hA HEK293_TMG_2hB CYB561D1 protein_coding protein_coding 4.986129 6.624643 3.711262 0.343984 0.03258316 -0.8342268 0.1909196 0.9634818 0.0511650 0.1359622 0.05116500 -3.99237577 0.02987083 0.14450000 0.01403333 -0.13046667 0.01281376 0.01281376 FALSE FALSE
ENST00000420578 ENSG00000174151 HEK293_OSMI2_2hA HEK293_TMG_2hB CYB561D1 protein_coding protein_coding 4.986129 6.624643 3.711262 0.343984 0.03258316 -0.8342268 1.5771172 1.8063516 1.1279862 0.3512127 0.56399593 -0.67456042 0.33485000 0.26840000 0.30573333 0.03733333 0.97962654 0.01281376 FALSE TRUE
ENST00000496961 ENSG00000174151 HEK293_OSMI2_2hA HEK293_TMG_2hB CYB561D1 protein_coding protein_coding 4.986129 6.624643 3.711262 0.343984 0.03258316 -0.8342268 0.5194163 0.5311842 0.4700922 0.3337176 0.10546917 -0.17280819 0.09818750 0.08056667 0.12623333 0.04566667 0.69703736 0.01281376 FALSE FALSE
ENST00000533024 ENSG00000174151 HEK293_OSMI2_2hA HEK293_TMG_2hB CYB561D1 protein_coding protein_coding 4.986129 6.624643 3.711262 0.343984 0.03258316 -0.8342268 0.8768464 0.9930719 0.2045681 0.2782320 0.20456807 -2.22491774 0.15977500 0.15533333 0.05610000 -0.09923333 0.26124764 0.01281376 FALSE FALSE
MSTRG.1756.2 ENSG00000174151 HEK293_OSMI2_2hA HEK293_TMG_2hB CYB561D1 protein_coding   4.986129 6.624643 3.711262 0.343984 0.03258316 -0.8342268 0.5035357 0.4016498 0.3815276 0.1495869 0.07184994 -0.07230386 0.09672083 0.06340000 0.10253333 0.03913333 0.56133725 0.01281376 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000174151 E001 4.9058954 0.0200854730 0.5874330178 0.7107289541 1 109494052 109494075 24 + 0.768 0.708 -0.247
ENSG00000174151 E002 4.5372012 0.0054677148 0.6382001856 0.7518813276 1 109494076 109494078 3 + 0.734 0.685 -0.205
ENSG00000174151 E003 4.3920285 0.0083008217 0.8359153472 0.8974065823 1 109494079 109494079 1 + 0.697 0.685 -0.052
ENSG00000174151 E004 7.2308305 0.0023414056 0.8123424522 0.8809780713 1 109494080 109494093 14 + 0.883 0.873 -0.037
ENSG00000174151 E005 7.5555175 0.0023865301 0.7405125253 0.8299093491 1 109494094 109494098 5 + 0.907 0.887 -0.077
ENSG00000174151 E006 7.5555175 0.0023865301 0.7405125253 0.8299093491 1 109494099 109494099 1 + 0.907 0.887 -0.077
ENSG00000174151 E007 8.6573589 0.0026504558 0.9961501206 1.0000000000 1 109494100 109494104 5 + 0.930 0.950 0.073
ENSG00000174151 E008 11.2165002 0.0022992293 0.8117326865 0.8805342504 1 109494105 109494113 9 + 1.048 1.044 -0.016
ENSG00000174151 E009 11.0713275 0.0062374526 0.9493860612 0.9723156365 1 109494114 109494114 1 + 1.031 1.045 0.051
ENSG00000174151 E010 18.7143060 0.0011353237 0.8435558522 0.9025806545 1 109494115 109494154 40 + 1.251 1.256 0.017
ENSG00000174151 E011 22.7575278 0.0061351789 0.1112221392 0.2073500094 1 109494155 109494287 133 + 1.404 1.297 -0.372
ENSG00000174151 E012 18.5772067 0.0010804821 0.0799899831 0.1595448231 1 109494520 109494623 104 + 1.338 1.219 -0.418
ENSG00000174151 E013 24.6510780 0.0009405026 0.1845895983 0.3069639370 1 109495143 109495180 38 + 1.426 1.353 -0.252
ENSG00000174151 E014 6.0272676 0.0028448679 0.2973439700 0.4386631086 1 109495679 109495755 77 + 0.697 0.859 0.645
ENSG00000174151 E015 93.3301581 0.0007557271 0.0001323582 0.0006692335 1 109495756 109496255 500 + 2.015 1.896 -0.402
ENSG00000174151 E016 633.6217210 0.0023140449 0.0003080471 0.0014123574 1 109496256 109500440 4185 + 2.722 2.786 0.215
ENSG00000174151 E017 0.1817044 0.0391180698 0.9652897118   1 109502383 109502932 550 + 0.000 0.093 8.365