ENSG00000174137

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000308132 ENSG00000174137 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM53A protein_coding protein_coding 1.848334 3.053449 1.067689 0.2319869 0.09336078 -1.507216 0.1477215 0.3144255 0.01866260 0.04627938 0.01866260 -3.500646 0.07719167 0.10216667 0.01533333 -0.08683333 0.03963235 0.03963235 FALSE TRUE
ENST00000461064 ENSG00000174137 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM53A protein_coding protein_coding 1.848334 3.053449 1.067689 0.2319869 0.09336078 -1.507216 0.7439603 1.4871063 0.46655071 0.21135358 0.04253706 -1.651475 0.39184583 0.48770000 0.44200000 -0.04570000 0.84142930 0.03963235 FALSE TRUE
ENST00000489363 ENSG00000174137 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM53A protein_coding protein_coding 1.848334 3.053449 1.067689 0.2319869 0.09336078 -1.507216 0.1602441 0.1612925 0.07161744 0.01024069 0.01999573 -1.069512 0.09293750 0.05326667 0.07123333 0.01796667 0.87062781 0.03963235 FALSE TRUE
MSTRG.24443.3 ENSG00000174137 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM53A protein_coding   1.848334 3.053449 1.067689 0.2319869 0.09336078 -1.507216 0.4555234 0.7198697 0.47885882 0.37061703 0.12447909 -0.578221 0.22749583 0.22360000 0.43570000 0.21210000 0.60950052 0.03963235 TRUE TRUE
MSTRG.24443.6 ENSG00000174137 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM53A protein_coding   1.848334 3.053449 1.067689 0.2319869 0.09336078 -1.507216 0.2350049 0.3081766 0.03199977 0.23818825 0.03199977 -2.921375 0.14125833 0.11393333 0.03573333 -0.07820000 0.79556829 0.03963235 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000174137 E001 0.6245948 0.025639737 0.466455039 0.60598180 4 1617915 1618111 197 - 0.000 0.190 9.758
ENSG00000174137 E002 2.3132793 0.006557003 0.129412010 0.23335160 4 1639887 1640444 558 - 0.199 0.504 1.914
ENSG00000174137 E003 1.6273616 0.009261559 0.917240284 0.95171768 4 1640445 1640465 21 - 0.335 0.358 0.137
ENSG00000174137 E004 2.1756839 0.007493484 0.915946984 0.95084967 4 1640466 1640494 29 - 0.438 0.422 -0.085
ENSG00000174137 E005 3.0560800 0.005291661 0.987033322 0.99594413 4 1640495 1640528 34 - 0.522 0.528 0.031
ENSG00000174137 E006 5.9887573 0.006529798 0.446371800 0.58787322 4 1640529 1640601 73 - 0.652 0.774 0.503
ENSG00000174137 E007 4.8126180 0.003615506 0.252611166 0.38898810 4 1640602 1640617 16 - 0.522 0.716 0.853
ENSG00000174137 E008 8.3199708 0.002802115 0.765578415 0.84829669 4 1640618 1640740 123 - 0.901 0.869 -0.125
ENSG00000174137 E009 10.0118775 0.001875900 0.875151340 0.92379416 4 1640741 1640864 124 - 0.961 0.947 -0.052
ENSG00000174137 E010 9.5787148 0.015283865 0.218379008 0.34845695 4 1640865 1641111 247 - 1.036 0.893 -0.535
ENSG00000174137 E011 8.4110014 0.044219199 0.062857916 0.13147240 4 1641112 1641230 119 - 0.592 0.934 1.386
ENSG00000174137 E012 30.9035202 0.018245678 0.902798497 0.94211482 4 1641231 1641561 331 - 1.394 1.417 0.078
ENSG00000174137 E013 11.7215651 0.008494994 0.387536264 0.53168008 4 1641562 1641607 46 - 0.932 1.042 0.408
ENSG00000174137 E014 0.6298062 0.019584995 0.963637424 0.98106673 4 1644189 1644342 154 - 0.199 0.189 -0.090
ENSG00000174137 E015 0.3697384 0.027442404 0.779274099 0.85804122 4 1644343 1644953 611 - 0.000 0.135 11.125
ENSG00000174137 E016 43.9531618 0.012043335 0.736205784 0.82675537 4 1654978 1655723 746 - 1.540 1.568 0.094
ENSG00000174137 E017 16.2282901 0.007494547 0.686691843 0.78916470 4 1657408 1657468 61 - 1.174 1.140 -0.125
ENSG00000174137 E018 21.7434720 0.002230487 0.003980439 0.01308762 4 1668667 1668905 239 - 1.424 1.208 -0.754
ENSG00000174137 E019 2.0982654 0.007021671 0.915793764 0.95073750 4 1683694 1683957 264 - 0.438 0.422 -0.086
ENSG00000174137 E020 0.6986918 0.016799670 0.966726534 0.98313574 4 1683958 1684232 275 - 0.199 0.190 -0.086
ENSG00000174137 E021 4.1233643 0.004059470 0.461334155 0.60131253 4 1684233 1684318 86 - 0.522 0.650 0.578