ENSG00000174106

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000308330 ENSG00000174106 HEK293_OSMI2_2hA HEK293_TMG_2hB LEMD3 protein_coding protein_coding 12.59221 3.767277 20.06521 0.5922257 0.2737872 2.409997 10.5303319 1.8912816 18.4050948 0.2373570 0.7386196 3.2758447 0.74905 0.5164000 0.9173 0.4009000 0.0002442150 0.000244215 FALSE TRUE
ENST00000544506 ENSG00000174106 HEK293_OSMI2_2hA HEK293_TMG_2hB LEMD3 protein_coding retained_intron 12.59221 3.767277 20.06521 0.5922257 0.2737872 2.409997 0.7520403 1.3135400 0.1373817 0.3786068 0.1373817 -3.1667725 0.13250 0.3347667 0.0070 -0.3277667 0.0009515375 0.000244215   FALSE
MSTRG.7582.4 ENSG00000174106 HEK293_OSMI2_2hA HEK293_TMG_2hB LEMD3 protein_coding   12.59221 3.767277 20.06521 0.5922257 0.2737872 2.409997 0.8962878 0.5085903 0.7433205 0.2601014 0.7433205 0.5386686 0.07555 0.1342000 0.0371 -0.0971000 0.3944373124 0.000244215 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000174106 E001 33.038589 0.0006343616 5.377157e-03 1.695380e-02 12 65169583 65169629 47 + 1.437 1.170 -0.936
ENSG00000174106 E002 122.600847 0.0118062712 3.131890e-02 7.451985e-02 12 65169630 65170209 580 + 1.984 1.820 -0.552
ENSG00000174106 E003 82.104013 0.0047743069 1.161738e-01 2.145188e-01 12 65170210 65170418 209 + 1.806 1.696 -0.371
ENSG00000174106 E004 232.852134 0.0025873687 2.267152e-03 8.051610e-03 12 65170419 65171118 700 + 2.257 2.129 -0.427
ENSG00000174106 E005 57.621937 0.0004062392 3.344307e-02 7.866709e-02 12 65210926 65210963 38 + 1.661 1.514 -0.502
ENSG00000174106 E006 70.923837 0.0003485043 1.148028e-02 3.230791e-02 12 65215977 65216043 67 + 1.751 1.592 -0.539
ENSG00000174106 E007 42.429260 0.0004987328 2.860934e-02 6.922653e-02 12 65218552 65218554 3 + 1.537 1.360 -0.611
ENSG00000174106 E008 69.141824 0.0004002743 1.312066e-02 3.618784e-02 12 65218555 65218619 65 + 1.741 1.583 -0.536
ENSG00000174106 E009 85.835214 0.0003387090 3.825863e-02 8.783623e-02 12 65238502 65238581 80 + 1.827 1.710 -0.394
ENSG00000174106 E010 128.369933 0.0003165371 1.055215e-03 4.150640e-03 12 65238669 65238814 146 + 2.003 1.850 -0.517
ENSG00000174106 E011 110.562692 0.0004418750 5.682887e-03 1.777399e-02 12 65239929 65240030 102 + 1.940 1.802 -0.466
ENSG00000174106 E012 92.361867 0.0012089979 7.809144e-02 1.564033e-01 12 65240136 65240238 103 + 1.858 1.761 -0.329
ENSG00000174106 E013 1.483327 0.0089616177 1.821879e-01 3.039393e-01 12 65240566 65240908 343 + 0.363 0.001 -9.698
ENSG00000174106 E014 117.545326 0.0013315846 6.057636e-01 7.260902e-01 12 65240909 65241087 179 + 1.950 1.922 -0.092
ENSG00000174106 E015 77.687565 0.0034184721 6.723603e-01 7.783432e-01 12 65243388 65243448 61 + 1.773 1.742 -0.104
ENSG00000174106 E016 63.532640 0.0017870249 2.200066e-01 3.504212e-01 12 65243449 65243469 21 + 1.694 1.610 -0.287
ENSG00000174106 E017 1.202558 0.3692780196 1.000000e+00 1.000000e+00 12 65245300 65245549 250 + 0.284 0.254 -0.213
ENSG00000174106 E018 1.040434 0.0121989077 1.000000e+00 1.000000e+00 12 65245550 65245668 119 + 0.251 0.258 0.048
ENSG00000174106 E019 105.160831 0.0007723348 2.564135e-02 6.320462e-02 12 65245669 65245774 106 + 1.914 1.797 -0.394
ENSG00000174106 E020 5.258368 0.0031715900 5.325930e-01 6.649301e-01 12 65245775 65245860 86 + 0.668 0.768 0.412
ENSG00000174106 E021 98.443255 0.0002936872 1.025194e-01 1.943482e-01 12 65245861 65245939 79 + 1.881 1.797 -0.285
ENSG00000174106 E022 581.388498 0.0002054456 4.765491e-54 3.761700e-51 12 65246162 65248355 2194 + 2.587 2.829 0.805