ENSG00000174032

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000519676 ENSG00000174032 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A30 protein_coding protein_coding 8.721111 4.113759 14.14079 0.9508649 0.5458436 1.778851 5.6343456 2.6207509 8.2549774 0.76357096 0.1719260 1.6515362 0.66409167 0.6235333 0.58470000 -0.03883333 8.639230e-01 6.879874e-06 FALSE TRUE
ENST00000539591 ENSG00000174032 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A30 protein_coding protein_coding 8.721111 4.113759 14.14079 0.9508649 0.5458436 1.778851 0.1860843 0.6556349 0.5795996 0.35802831 0.3267724 -0.1749956 0.02989583 0.1811333 0.03946667 -0.14166667 7.689756e-01 6.879874e-06 FALSE TRUE
MSTRG.8707.4 ENSG00000174032 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A30 protein_coding   8.721111 4.113759 14.14079 0.9508649 0.5458436 1.778851 1.4540720 0.4366421 2.3986691 0.08342486 0.2565559 2.4310450 0.15525417 0.1086000 0.16916667 0.06056667 1.505854e-01 6.879874e-06 FALSE TRUE
MSTRG.8707.6 ENSG00000174032 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A30 protein_coding   8.721111 4.113759 14.14079 0.9508649 0.5458436 1.778851 0.6082988 0.0000000 1.6549621 0.00000000 0.3925830 7.3793455 0.04519583 0.0000000 0.11903333 0.11903333 6.879874e-06 6.879874e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000174032 E001 0.0000000       13 45393316 45393333 18 -      
ENSG00000174032 E002 16.0829203 0.0072926993 2.883430e-08 3.256765e-07 13 45393334 45393449 116 - 0.981 1.506 1.856
ENSG00000174032 E003 509.1779273 0.0011241181 1.314374e-13 3.675339e-12 13 45393450 45395947 2498 - 2.626 2.759 0.440
ENSG00000174032 E004 54.0752624 0.0005808647 2.650645e-02 6.496206e-02 13 45395948 45396015 68 - 1.727 1.622 -0.355
ENSG00000174032 E005 11.9528203 0.0014891957 6.524643e-02 1.354483e-01 13 45396016 45396071 56 - 1.118 0.924 -0.713
ENSG00000174032 E006 13.1944261 0.0012770685 6.834323e-02 1.406365e-01 13 45396072 45396172 101 - 1.159 0.979 -0.654
ENSG00000174032 E007 12.7862040 0.0014505538 1.004781e-01 1.911845e-01 13 45396173 45396318 146 - 1.142 0.979 -0.593
ENSG00000174032 E008 3.5428746 0.0049077903 3.011169e-01 4.428842e-01 13 45396319 45397257 939 - 0.674 0.515 -0.714
ENSG00000174032 E009 43.9081743 0.0021821376 8.559247e-01 9.109325e-01 13 45397258 45397338 81 - 1.611 1.616 0.016
ENSG00000174032 E010 0.7447779 0.1295389190 2.292986e-01 3.615986e-01 13 45397339 45397886 548 - 0.286 0.000 -10.349
ENSG00000174032 E011 1.9282169 0.0090510631 7.319746e-02 1.486349e-01 13 45397887 45398064 178 - 0.326 0.644 1.608
ENSG00000174032 E012 2.1497534 0.0068241453 3.133557e-01 4.559329e-01 13 45398065 45398939 875 - 0.510 0.330 -0.975
ENSG00000174032 E013 76.6809158 0.0004054438 5.302149e-01 6.628588e-01 13 45398940 45399078 139 - 1.854 1.843 -0.035
ENSG00000174032 E014 51.0073362 0.0004824912 1.024459e-01 1.942483e-01 13 45401083 45401131 49 - 1.696 1.622 -0.249
ENSG00000174032 E015 51.7347909 0.0005052421 5.535710e-03 1.738053e-02 13 45401132 45401187 56 - 1.718 1.579 -0.472
ENSG00000174032 E016 39.6055505 0.0110340823 7.292144e-02 1.481983e-01 13 45401188 45401207 20 - 1.601 1.480 -0.414
ENSG00000174032 E017 53.0343950 0.0023206834 9.374345e-03 2.721875e-02 13 45402275 45402325 51 - 1.729 1.591 -0.468
ENSG00000174032 E018 51.5807291 0.0005793245 4.096840e-02 9.282457e-02 13 45402326 45402370 45 - 1.707 1.610 -0.328
ENSG00000174032 E019 53.3745083 0.0004935541 5.013637e-02 1.094071e-01 13 45404327 45404412 86 - 1.718 1.628 -0.305
ENSG00000174032 E020 49.7845010 0.0054797951 2.260314e-01 3.576353e-01 13 45405883 45405977 95 - 1.683 1.615 -0.229
ENSG00000174032 E021 56.9603756 0.0077196672 1.802672e-01 3.015121e-01 13 45408927 45409074 148 - 1.742 1.656 -0.291
ENSG00000174032 E022 0.4418608 0.0251035353 4.550899e-01 5.956489e-01 13 45410553 45410610 58 - 0.193 0.000 -10.245
ENSG00000174032 E023 46.4488082 0.0368708560 2.200060e-01 3.504212e-01 13 45411362 45411480 119 - 1.667 1.544 -0.420
ENSG00000174032 E024 2.4993202 0.0324909495 1.783948e-01 2.991305e-01 13 45411733 45411938 206 - 0.579 0.329 -1.301
ENSG00000174032 E025 5.8230399 0.0029492578 1.795929e-02 4.704749e-02 13 45418231 45418299 69 - 0.876 0.515 -1.520
ENSG00000174032 E026 25.9294831 0.0188244018 1.820065e-01 3.037348e-01 13 45418300 45418455 156 - 1.423 1.294 -0.451