ENSG00000174010

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000328046 ENSG00000174010 HEK293_OSMI2_2hA HEK293_TMG_2hB KLHL15 protein_coding protein_coding 7.653233 2.221225 13.80224 0.7929306 0.1123234 2.63004 2.9071347 1.76782261 1.278629 0.39847066 1.2786288 -0.4642747 0.50338333 0.86443333 0.09376667 -0.77066667 3.563601e-02 2.063921e-21 FALSE TRUE
ENST00000685367 ENSG00000174010 HEK293_OSMI2_2hA HEK293_TMG_2hB KLHL15 protein_coding protein_coding 7.653233 2.221225 13.80224 0.7929306 0.1123234 2.63004 2.6956625 0.03142212 8.079337 0.03142212 0.1837671 7.6094763 0.27932083 0.02446667 0.58556667 0.56110000 2.063921e-21 2.063921e-21 FALSE TRUE
ENST00000689334 ENSG00000174010 HEK293_OSMI2_2hA HEK293_TMG_2hB KLHL15 protein_coding protein_coding 7.653233 2.221225 13.80224 0.7929306 0.1123234 2.63004 0.8703907 0.00000000 2.285190 0.00000000 1.1821493 7.8424698 0.06400417 0.00000000 0.16433333 0.16433333 4.050188e-01 2.063921e-21 FALSE TRUE
ENST00000692681 ENSG00000174010 HEK293_OSMI2_2hA HEK293_TMG_2hB KLHL15 protein_coding protein_coding 7.653233 2.221225 13.80224 0.7929306 0.1123234 2.63004 1.0689669 0.36735590 1.928069 0.36735590 0.6001372 2.3606219 0.14375417 0.09673333 0.13950000 0.04276667 5.829320e-01 2.063921e-21 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000174010 E001 0.0000000       X 23983716 23983718 3 -      
ENSG00000174010 E002 0.0000000       X 23983719 23983719 1 -      
ENSG00000174010 E003 0.0000000       X 23983720 23983731 12 -      
ENSG00000174010 E004 281.4956428 0.0129440859 1.877273e-22 1.575038e-20 X 23983732 23984854 1123 - 2.138 2.749 2.036
ENSG00000174010 E005 304.2783136 0.0012940603 5.122810e-05 2.879227e-04 X 23984855 23986398 1544 - 2.277 2.536 0.864
ENSG00000174010 E006 232.5395581 0.0016667806 5.488785e-08 5.863505e-07 X 23986399 23987938 1540 - 2.210 2.165 -0.150
ENSG00000174010 E007 259.5354399 0.0002534973 1.332927e-47 7.173836e-45 X 23987939 23989030 1092 - 2.286 1.914 -1.244
ENSG00000174010 E008 165.6167408 0.0029599133 7.171686e-17 3.140911e-15 X 24005989 24006700 712 - 2.086 1.804 -0.946
ENSG00000174010 E009 0.1451727 0.0471929143 1.000000e+00   X 24024616 24024678 63 - 0.048 0.000 -7.303
ENSG00000174010 E010 0.1451727 0.0471929143 1.000000e+00   X 24024679 24024856 178 - 0.048 0.000 -7.303
ENSG00000174010 E011 47.8569866 0.0004998850 1.365451e-12 3.271954e-11 X 24024857 24025058 202 - 1.568 1.042 -1.845
ENSG00000174010 E012 24.7400838 0.0008014329 1.195180e-10 2.083010e-09 X 24025059 24025317 259 - 1.305 0.451 -3.395
ENSG00000174010 E013 0.4502799 0.0342645083 1.000000e+00 1.000000e+00 X 24025630 24025685 56 - 0.130 0.000 -8.929
ENSG00000174010 E014 0.1515154 0.0477948267 1.000000e+00   X 24027140 24027186 47 - 0.048 0.000 -7.302
ENSG00000174010 E015 1.3359761 0.0100033076 6.086994e-01 7.283516e-01 X 24054740 24055030 291 - 0.259 0.450 1.162