ENSG00000173992

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000526066 ENSG00000173992 HEK293_OSMI2_2hA HEK293_TMG_2hB CCS protein_coding retained_intron 39.76817 68.79369 22.94503 1.842768 0.7923775 -1.583675 4.173769 3.031703 2.077485 0.6135676 0.5254244 -0.5431136 0.12795833 0.04430000 0.08926667 0.04496667 0.218732036 0.003292787 FALSE FALSE
ENST00000530384 ENSG00000173992 HEK293_OSMI2_2hA HEK293_TMG_2hB CCS protein_coding retained_intron 39.76817 68.79369 22.94503 1.842768 0.7923775 -1.583675 2.392472 3.819860 2.128882 0.6029037 0.2317786 -0.8404349 0.06574583 0.05513333 0.09233333 0.03720000 0.102584910 0.003292787 TRUE FALSE
ENST00000533244 ENSG00000173992 HEK293_OSMI2_2hA HEK293_TMG_2hB CCS protein_coding protein_coding 39.76817 68.79369 22.94503 1.842768 0.7923775 -1.583675 26.675257 54.598749 14.830084 1.1166678 0.6202804 -1.8796328 0.62492500 0.79416667 0.64716667 -0.14700000 0.003292787 0.003292787 FALSE TRUE
ENST00000534763 ENSG00000173992 HEK293_OSMI2_2hA HEK293_TMG_2hB CCS protein_coding protein_coding 39.76817 68.79369 22.94503 1.842768 0.7923775 -1.583675 3.768773 3.301570 2.232313 0.2858329 0.2344946 -0.5625273 0.11085417 0.04780000 0.09796667 0.05016667 0.003453485 0.003292787 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000173992 E001 12.416297 0.0014734652 1.362411e-01 2.428066e-01 11 66593153 66593184 32 + 1.150 0.995 -0.562
ENSG00000173992 E002 14.694180 0.0012446783 2.316334e-02 5.808834e-02 11 66593185 66593189 5 + 1.262 1.046 -0.772
ENSG00000173992 E003 76.977493 0.0037810415 2.275826e-02 5.724602e-02 11 66593190 66593200 11 + 1.888 1.769 -0.403
ENSG00000173992 E004 84.797228 0.0027412006 1.314976e-02 3.625489e-02 11 66593201 66593203 3 + 1.930 1.809 -0.406
ENSG00000173992 E005 153.423053 0.0040258179 2.345922e-01 3.678613e-01 11 66593204 66593232 29 + 2.131 2.080 -0.170
ENSG00000173992 E006 156.000552 0.0037996342 3.198303e-01 4.629075e-01 11 66593233 66593240 8 + 2.131 2.089 -0.139
ENSG00000173992 E007 221.112351 0.0008466005 4.887317e-01 6.262598e-01 11 66593241 66593300 60 + 2.262 2.243 -0.062
ENSG00000173992 E008 3.759028 0.0043689577 6.262577e-02 1.310625e-01 11 66593610 66593641 32 + 0.804 0.520 -1.216
ENSG00000173992 E009 238.013724 0.0002053106 9.230925e-01 9.554976e-01 11 66593642 66593714 73 + 2.275 2.280 0.019
ENSG00000173992 E010 290.783483 0.0001935128 1.411229e-01 2.495827e-01 11 66599116 66599253 138 + 2.334 2.374 0.134
ENSG00000173992 E011 38.779160 0.0006230513 6.385207e-05 3.503007e-04 11 66599254 66599458 205 + 1.682 1.439 -0.831
ENSG00000173992 E012 369.770737 0.0008550476 7.632441e-01 8.466168e-01 11 66599459 66599636 178 + 2.471 2.468 -0.012
ENSG00000173992 E013 27.321789 0.0242737661 7.895193e-03 2.351540e-02 11 66599637 66599803 167 + 1.559 1.287 -0.941
ENSG00000173992 E014 35.680639 0.0006057705 6.572435e-08 6.918532e-07 11 66600034 66600434 401 + 1.708 1.375 -1.139
ENSG00000173992 E015 15.356477 0.0013365788 1.074538e-01 2.017823e-01 11 66600435 66600488 54 + 1.233 1.080 -0.547
ENSG00000173992 E016 308.769897 0.0005575312 3.628319e-01 5.072505e-01 11 66600489 66600549 61 + 2.369 2.397 0.091
ENSG00000173992 E017 26.791006 0.0008148228 4.714825e-01 6.105912e-01 11 66605154 66605338 185 + 1.385 1.331 -0.187
ENSG00000173992 E018 348.643081 0.0011435066 1.170837e-01 2.157847e-01 11 66605339 66605416 78 + 2.406 2.452 0.154
ENSG00000173992 E019 389.156199 0.0015877223 3.548595e-02 8.258852e-02 11 66605489 66605592 104 + 2.442 2.505 0.210
ENSG00000173992 E020 395.539781 0.0015465827 2.041833e-04 9.818814e-04 11 66605702 66606019 318 + 2.412 2.519 0.359