ENSG00000173914

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000310046 ENSG00000173914 HEK293_OSMI2_2hA HEK293_TMG_2hB RBM4B protein_coding protein_coding 23.3058 25.50371 22.72066 1.377933 0.6271679 -0.166633 15.039459 18.3169099 11.884130 1.4257578 0.3252054 -0.6237138 0.64410833 0.71633333 0.5246000 -0.19173333 2.587385e-04 3.596794e-05 FALSE TRUE
ENST00000529195 ENSG00000173914 HEK293_OSMI2_2hA HEK293_TMG_2hB RBM4B protein_coding processed_transcript 23.3058 25.50371 22.72066 1.377933 0.6271679 -0.166633 1.214321 0.5619434 2.046754 0.1204757 0.2831933 1.8464247 0.05212083 0.02166667 0.0906000 0.06893333 3.596794e-05 3.596794e-05 FALSE TRUE
ENST00000531036 ENSG00000173914 HEK293_OSMI2_2hA HEK293_TMG_2hB RBM4B protein_coding protein_coding 23.3058 25.50371 22.72066 1.377933 0.6271679 -0.166633 3.984402 3.2715255 5.077238 0.4873956 0.4665774 0.6325160 0.17294167 0.12730000 0.2228667 0.09556667 6.379756e-03 3.596794e-05 FALSE TRUE
ENST00000531969 ENSG00000173914 HEK293_OSMI2_2hA HEK293_TMG_2hB RBM4B protein_coding protein_coding 23.3058 25.50371 22.72066 1.377933 0.6271679 -0.166633 1.560764 1.8700420 2.615754 0.5134840 0.4750885 0.4819670 0.06702500 0.07356667 0.1142000 0.04063333 4.623996e-01 3.596794e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000173914 E001 197.802024 0.0024882841 8.321732e-06 5.631258e-05 11 66664998 66665294 297 - 2.182 2.329 0.492
ENSG00000173914 E002 184.952380 0.0020702740 4.495208e-05 2.561214e-04 11 66665295 66665453 159 - 2.164 2.297 0.444
ENSG00000173914 E003 105.961739 0.0009231560 5.319607e-08 5.701746e-07 11 66665454 66665547 94 - 1.868 2.075 0.693
ENSG00000173914 E004 70.771413 0.0120608063 7.964351e-03 2.368675e-02 11 66665548 66665578 31 - 1.716 1.891 0.593
ENSG00000173914 E005 12.600453 0.0064598486 2.422354e-01 3.768271e-01 11 66665579 66665660 82 - 1.192 1.078 -0.411
ENSG00000173914 E006 21.104991 0.0134998503 8.044247e-10 1.214406e-08 11 66665906 66666271 366 - 1.609 1.037 -2.003
ENSG00000173914 E007 23.659895 0.0016181502 5.878970e-09 7.580678e-08 11 66666272 66666493 222 - 1.592 1.173 -1.455
ENSG00000173914 E008 2.960321 0.0058016814 7.313665e-05 3.952847e-04 11 66666494 66666495 2 - 0.874 0.252 -3.043
ENSG00000173914 E009 183.135477 0.0006958265 6.944371e-07 5.966937e-06 11 66668615 66668970 356 - 2.153 2.292 0.464
ENSG00000173914 E010 199.758283 0.0003591811 8.091382e-02 1.609652e-01 11 66668971 66669291 321 - 2.258 2.301 0.143
ENSG00000173914 E011 0.147249 0.0428285984 3.288125e-01   11 66670936 66670983 48 - 0.148 0.000 -9.787
ENSG00000173914 E012 122.628259 0.0092132804 1.316183e-06 1.065221e-05 11 66675560 66676667 1108 - 2.225 1.968 -0.863
ENSG00000173914 E013 316.538793 0.0002556555 7.907272e-10 1.195442e-08 11 66676668 66677091 424 - 2.557 2.440 -0.390
ENSG00000173914 E014 2.576432 0.1741501974 9.201134e-01 9.535394e-01 11 66677092 66677748 657 - 0.583 0.521 -0.284
ENSG00000173914 E015 86.937753 0.0022011878 8.889648e-07 7.464065e-06 11 66677764 66677887 124 - 2.050 1.837 -0.716