ENSG00000173852

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000310974 ENSG00000173852 HEK293_OSMI2_2hA HEK293_TMG_2hB DPY19L1 protein_coding protein_coding 15.43252 4.659457 25.6975 0.9142839 1.022298 2.460863 6.0916366 3.5096403 5.39128549 0.70436408 2.85057450 0.6178748 0.4871833 0.7514333 0.201733333 -0.54970000 0.0069563849 7.80311e-05 FALSE TRUE
ENST00000612226 ENSG00000173852 HEK293_OSMI2_2hA HEK293_TMG_2hB DPY19L1 protein_coding protein_coding 15.43252 4.659457 25.6975 0.9142839 1.022298 2.460863 0.1661277 0.2946696 0.08343752 0.14635362 0.05349591 -1.7051715 0.0316875 0.0572000 0.003166667 -0.05403333 0.0009453079 7.80311e-05 FALSE TRUE
ENST00000638088 ENSG00000173852 HEK293_OSMI2_2hA HEK293_TMG_2hB DPY19L1 protein_coding protein_coding 15.43252 4.659457 25.6975 0.9142839 1.022298 2.460863 7.5403426 0.4481494 18.20622199 0.06833254 2.03906363 5.3132617 0.3768500 0.1082333 0.716866667 0.60863333 0.0000780311 7.80311e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000173852 E001 28.7322202 0.0007079261 8.337098e-04 3.379417e-03 7 34927292 34928875 1584 - 1.247 1.615 1.269
ENSG00000173852 E002 1.8520211 0.0077286438 5.486700e-01 6.785115e-01 7 34928876 34928880 5 - 0.357 0.282 -0.478
ENSG00000173852 E003 873.4607750 0.0147576006 9.999383e-09 1.233222e-07 7 34928881 34931456 2576 - 2.705 3.069 1.211
ENSG00000173852 E004 72.2444553 0.0048219031 6.984911e-01 7.984448e-01 7 34931457 34931567 111 - 1.681 1.823 0.478
ENSG00000173852 E005 107.3809530 0.0004008931 5.234376e-01 6.571396e-01 7 34931568 34931729 162 - 1.848 1.991 0.479
ENSG00000173852 E006 11.0151518 0.1351367843 7.463847e-01 8.341809e-01 7 34932798 34937993 5196 - 0.920 0.935 0.057
ENSG00000173852 E007 124.7405053 0.0034035084 3.334657e-01 4.771924e-01 7 34937994 34938117 124 - 1.925 1.986 0.206
ENSG00000173852 E008 55.3328843 0.0007439945 4.518252e-02 1.005284e-01 7 34938118 34938119 2 - 1.591 1.564 -0.092
ENSG00000173852 E009 112.1770833 0.0005166818 2.605852e-01 3.981349e-01 7 34939276 34939375 100 - 1.879 1.939 0.202
ENSG00000173852 E010 147.9365297 0.0002618343 5.119361e-02 1.112785e-01 7 34940153 34940327 175 - 2.001 2.033 0.109
ENSG00000173852 E011 112.9738358 0.0010223992 2.698428e-01 4.083956e-01 7 34941765 34941884 120 - 1.883 1.943 0.202
ENSG00000173852 E012 60.7360800 0.0014391306 8.713525e-02 1.708003e-01 7 34942615 34942639 25 - 1.627 1.624 -0.009
ENSG00000173852 E013 65.1023985 0.0012359747 3.577433e-02 8.314525e-02 7 34945667 34945682 16 - 1.659 1.634 -0.086
ENSG00000173852 E014 84.8722252 0.0005295674 3.193306e-01 4.624061e-01 7 34945683 34945716 34 - 1.760 1.819 0.199
ENSG00000173852 E015 100.6436679 0.0002880148 1.444583e-01 2.540893e-01 7 34947630 34947701 72 - 1.835 1.875 0.135
ENSG00000173852 E016 0.4804688 0.0219666586 3.655121e-01 5.098305e-01 7 34947702 34948043 342 - 0.091 0.282 1.981
ENSG00000173852 E017 118.2996423 0.0003627232 1.943677e-01 3.192424e-01 7 34949797 34949898 102 - 1.904 1.957 0.179
ENSG00000173852 E018 0.0000000       7 34954546 34954697 152 -      
ENSG00000173852 E019 91.0840053 0.0406014127 3.792450e-01 5.235199e-01 7 34954698 34954778 81 - 1.799 1.796 -0.010
ENSG00000173852 E020 63.0983333 0.0401439192 3.019944e-01 4.438268e-01 7 34955308 34955328 21 - 1.646 1.616 -0.101
ENSG00000173852 E021 72.9999236 0.0086746945 2.490115e-01 3.847554e-01 7 34955329 34955367 39 - 1.702 1.717 0.051
ENSG00000173852 E022 87.1926513 0.0005144162 4.070778e-02 9.233234e-02 7 34957984 34958070 87 - 1.781 1.781 0.000
ENSG00000173852 E023 95.0021476 0.0004353438 3.498679e-02 8.162838e-02 7 34966894 34966971 78 - 1.817 1.819 0.006
ENSG00000173852 E024 104.9049912 0.0022141421 1.277850e-03 4.903678e-03 7 34969433 34969532 100 - 1.868 1.794 -0.247
ENSG00000173852 E025 0.1451727 0.0440489852 9.593796e-01   7 34973513 34973513 1 - 0.048 0.000 -9.078
ENSG00000173852 E026 106.9054063 0.0003190184 2.805157e-08 3.176311e-07 7 34973514 34973605 92 - 1.888 1.694 -0.654
ENSG00000173852 E027 0.0000000       7 34987970 34988234 265 -      
ENSG00000173852 E028 5.2864581 0.0030224880 1.120743e-01 2.085836e-01 7 34989355 34989447 93 - 0.683 0.452 -1.064
ENSG00000173852 E029 74.6098730 0.0003205663 1.737226e-08 2.048885e-07 7 34989884 34989941 58 - 1.742 1.467 -0.936
ENSG00000173852 E030 0.0000000       7 35000393 35000702 310 -      
ENSG00000173852 E031 95.2540956 0.0002786025 1.946323e-09 2.731548e-08 7 35010468 35010561 94 - 1.843 1.595 -0.839
ENSG00000173852 E032 113.4586499 0.0009278588 5.161522e-09 6.717135e-08 7 35011330 35011450 121 - 1.916 1.702 -0.721
ENSG00000173852 E033 101.0867634 0.0345142397 4.285133e-03 1.394112e-02 7 35013568 35013705 138 - 1.866 1.652 -0.724
ENSG00000173852 E034 52.6108503 0.0020546857 4.118785e-08 4.519499e-07 7 35017882 35017969 88 - 1.600 1.219 -1.320
ENSG00000173852 E035 0.1451727 0.0440489852 9.593796e-01   7 35017970 35017970 1 - 0.048 0.000 -9.078
ENSG00000173852 E036 22.0323611 0.0640721853 2.260398e-02 5.692748e-02 7 35018572 35018596 25 - 1.233 0.922 -1.132
ENSG00000173852 E037 34.3529502 0.0109938151 1.564365e-06 1.245385e-05 7 35037097 35037488 392 - 1.428 0.920 -1.819
ENSG00000173852 E038 0.0000000       7 35037818 35038041 224 -      
ENSG00000173852 E039 0.0000000       7 35038172 35038271 100 -