ENSG00000173846

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000372201 ENSG00000173846 HEK293_OSMI2_2hA HEK293_TMG_2hB PLK3 protein_coding protein_coding 1.941291 2.458324 1.46712 0.6153616 0.09305222 -0.7407447 0.54656671 0.93973114 0.3144928 0.27727989 0.01011084 -1.5493328 0.28990833 0.38263333 0.21670000 -0.165933333 0.12611350 0.04156737 FALSE TRUE
ENST00000461358 ENSG00000173846 HEK293_OSMI2_2hA HEK293_TMG_2hB PLK3 protein_coding processed_transcript 1.941291 2.458324 1.46712 0.6153616 0.09305222 -0.7407447 0.15022982 0.16352183 0.1938771 0.10904710 0.09717977 0.2325826 0.07701667 0.05303333 0.12480000 0.071766667 0.77056790 0.04156737 FALSE FALSE
ENST00000465443 ENSG00000173846 HEK293_OSMI2_2hA HEK293_TMG_2hB PLK3 protein_coding processed_transcript 1.941291 2.458324 1.46712 0.6153616 0.09305222 -0.7407447 0.15600769 0.13624385 0.1088294 0.08606016 0.03809102 -0.2994846 0.07986667 0.06300000 0.07243333 0.009433333 0.90324380 0.04156737 TRUE TRUE
ENST00000476731 ENSG00000173846 HEK293_OSMI2_2hA HEK293_TMG_2hB PLK3 protein_coding processed_transcript 1.941291 2.458324 1.46712 0.6153616 0.09305222 -0.7407447 0.18258870 0.06763082 0.1937616 0.03405360 0.04659657 1.3921808 0.09669583 0.02503333 0.13540000 0.110366667 0.04156737 0.04156737 TRUE TRUE
ENST00000492398 ENSG00000173846 HEK293_OSMI2_2hA HEK293_TMG_2hB PLK3 protein_coding processed_transcript 1.941291 2.458324 1.46712 0.6153616 0.09305222 -0.7407447 0.25081145 0.00000000 0.0000000 0.00000000 0.00000000 0.0000000 0.11384583 0.00000000 0.00000000 0.000000000   0.04156737 TRUE TRUE
ENST00000493100 ENSG00000173846 HEK293_OSMI2_2hA HEK293_TMG_2hB PLK3 protein_coding processed_transcript 1.941291 2.458324 1.46712 0.6153616 0.09305222 -0.7407447 0.08509522 0.10740804 0.1215244 0.10740804 0.12152435 0.1637987 0.05061667 0.02933333 0.07530000 0.045966667 0.97494468 0.04156737   FALSE
MSTRG.1058.3 ENSG00000173846 HEK293_OSMI2_2hA HEK293_TMG_2hB PLK3 protein_coding   1.941291 2.458324 1.46712 0.6153616 0.09305222 -0.7407447 0.24411895 0.20616086 0.1131485 0.10660945 0.06636700 -0.8117062 0.13482500 0.11060000 0.08363333 -0.026966667 0.96260396 0.04156737 TRUE TRUE
MSTRG.1058.4 ENSG00000173846 HEK293_OSMI2_2hA HEK293_TMG_2hB PLK3 protein_coding   1.941291 2.458324 1.46712 0.6153616 0.09305222 -0.7407447 0.30926190 0.83762734 0.4214863 0.24041954 0.10034788 -0.9741155 0.14855833 0.33640000 0.29173333 -0.044666667 0.82220085 0.04156737 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000173846 E001 1.1342230 0.2306557111 0.23210374 0.36493833 1 44800377 44800387 11 + 0.469 0.220 -1.563
ENSG00000173846 E002 1.2512830 0.0111504250 0.01209347 0.03375776 1 44800388 44800461 74 + 0.593 0.157 -2.745
ENSG00000173846 E003 5.7129913 0.0665909012 0.76309162 0.84654052 1 44800462 44800673 212 + 0.835 0.773 -0.243
ENSG00000173846 E004 8.6981559 0.0020247548 0.61047219 0.72979533 1 44800840 44800947 108 + 0.893 0.947 0.203
ENSG00000173846 E005 8.5328963 0.0021666967 0.33501920 0.47876456 1 44801036 44801152 117 + 0.835 0.947 0.427
ENSG00000173846 E006 4.8295342 0.0035155662 0.61942167 0.73683482 1 44801622 44801633 12 + 0.768 0.692 -0.311
ENSG00000173846 E007 12.4185359 0.0015725465 0.64403563 0.75644792 1 44801634 44801751 118 + 1.103 1.051 -0.189
ENSG00000173846 E008 13.4399481 0.0015167634 0.37592463 0.52030884 1 44801845 44801932 88 + 1.031 1.114 0.302
ENSG00000173846 E009 12.8477454 0.0015478276 0.35666325 0.50103710 1 44802760 44802855 96 + 1.010 1.099 0.322
ENSG00000173846 E010 16.7333110 0.0011887456 0.82822296 0.89205124 1 44802955 44803153 199 + 1.206 1.181 -0.091
ENSG00000173846 E011 1.4456598 0.0096765512 0.03114436 0.07418134 1 44803154 44803267 114 + 0.593 0.218 -2.160
ENSG00000173846 E012 13.0066754 0.0032470688 0.58538400 0.70909077 1 44803268 44803336 69 + 1.050 1.099 0.179
ENSG00000173846 E013 11.3823471 0.0076932199 0.48566156 0.62352098 1 44803337 44803391 55 + 0.989 1.059 0.257
ENSG00000173846 E014 12.1595494 0.0017030132 0.34067206 0.48462388 1 44803600 44803691 92 + 0.989 1.083 0.344
ENSG00000173846 E015 2.0575691 0.0072015677 0.18168137 0.30334189 1 44803692 44803930 239 + 0.593 0.363 -1.158
ENSG00000173846 E016 12.9730094 0.0015167634 0.28358673 0.42372610 1 44803931 44804024 94 + 1.010 1.113 0.374
ENSG00000173846 E017 10.2243905 0.0204572010 0.44661026 0.58810550 1 44804163 44804217 55 + 1.050 0.962 -0.324
ENSG00000173846 E018 8.6033585 0.1408052268 0.38713672 0.53128588 1 44804218 44804246 29 + 1.010 0.893 -0.437
ENSG00000173846 E019 16.5911813 0.0138010095 0.76075978 0.84475504 1 44804339 44804501 163 + 1.206 1.178 -0.100
ENSG00000173846 E020 2.0135870 0.1929318451 0.92045862 0.95379510 1 44804502 44804620 119 + 0.469 0.438 -0.156
ENSG00000173846 E021 0.9953799 0.0123404116 0.34575859 0.48989169 1 44804621 44804649 29 + 0.391 0.218 -1.160
ENSG00000173846 E022 10.2083451 0.0018737130 0.48048851 0.61877320 1 44804650 44804779 130 + 0.944 1.016 0.267
ENSG00000173846 E023 4.1881144 0.0046352972 0.36294398 0.50736526 1 44804780 44805265 486 + 0.768 0.630 -0.575
ENSG00000173846 E024 11.8071913 0.0017816963 0.65283881 0.76347962 1 44805266 44805379 114 + 1.086 1.034 -0.190
ENSG00000173846 E025 26.5763835 0.0009377332 0.68072764 0.78458240 1 44805487 44805990 504 + 1.360 1.382 0.078