ENSG00000173818

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000323854 ENSG00000173818 HEK293_OSMI2_2hA HEK293_TMG_2hB ENDOV protein_coding protein_coding 27.38604 44.04098 16.97653 3.230643 0.6449189 -1.374783 7.5079350 14.268897 3.8495834 0.92528981 0.45873120 -1.8873675 0.26620000 0.32570000 0.22586667 -0.099833333 8.059298e-02 3.182863e-14 FALSE  
ENST00000520537 ENSG00000173818 HEK293_OSMI2_2hA HEK293_TMG_2hB ENDOV protein_coding retained_intron 27.38604 44.04098 16.97653 3.230643 0.6449189 -1.374783 1.3494230 1.555681 1.3156201 0.09423390 0.17844642 -0.2401226 0.05382083 0.03546667 0.07760000 0.042133333 2.680877e-03 3.182863e-14 FALSE  
ENST00000521847 ENSG00000173818 HEK293_OSMI2_2hA HEK293_TMG_2hB ENDOV protein_coding processed_transcript 27.38604 44.04098 16.97653 3.230643 0.6449189 -1.374783 1.5286334 1.685861 1.0284903 0.07654375 0.09808751 -0.7075300 0.06136250 0.03843333 0.06030000 0.021866667 5.135799e-02 3.182863e-14    
ENST00000522200 ENSG00000173818 HEK293_OSMI2_2hA HEK293_TMG_2hB ENDOV protein_coding protein_coding 27.38604 44.04098 16.97653 3.230643 0.6449189 -1.374783 0.9875283 2.804692 0.0000000 0.54381700 0.00000000 -8.1368334 0.02992500 0.06286667 0.00000000 -0.062866667 3.182863e-14 3.182863e-14 FALSE  
ENST00000522751 ENSG00000173818 HEK293_OSMI2_2hA HEK293_TMG_2hB ENDOV protein_coding protein_coding 27.38604 44.04098 16.97653 3.230643 0.6449189 -1.374783 1.9563742 2.809623 1.6190346 0.40233055 0.48823481 -0.7914848 0.07375833 0.06336667 0.09760000 0.034233333 6.657840e-01 3.182863e-14 FALSE  
ENST00000523165 ENSG00000173818 HEK293_OSMI2_2hA HEK293_TMG_2hB ENDOV protein_coding processed_transcript 27.38604 44.04098 16.97653 3.230643 0.6449189 -1.374783 1.5094636 2.212688 0.6761432 1.25603218 0.07052247 -1.6957239 0.05187917 0.04700000 0.03966667 -0.007333333 9.134703e-01 3.182863e-14 FALSE  
ENST00000572886 ENSG00000173818 HEK293_OSMI2_2hA HEK293_TMG_2hB ENDOV protein_coding protein_coding 27.38604 44.04098 16.97653 3.230643 0.6449189 -1.374783 1.3801538 2.436061 0.8272996 0.44188828 0.20803779 -1.5466443 0.05297083 0.05450000 0.04870000 -0.005800000 8.715021e-01 3.182863e-14 FALSE  
MSTRG.15235.28 ENSG00000173818 HEK293_OSMI2_2hA HEK293_TMG_2hB ENDOV protein_coding   27.38604 44.04098 16.97653 3.230643 0.6449189 -1.374783 1.6949818 2.266466 0.9906645 0.31754355 0.52132184 -1.1858378 0.06007917 0.05120000 0.06080000 0.009600000 9.214553e-01 3.182863e-14 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000173818 E001 0.0000000       17 80414929 80414933 5 +      
ENSG00000173818 E002 0.0000000       17 80414934 80415136 203 +      
ENSG00000173818 E003 0.4782907 0.0222959471 4.140450e-01 5.574596e-01 17 80415137 80415164 28 + 0.000 0.196 9.284
ENSG00000173818 E004 0.6234634 0.0188669167 1.000000e+00 1.000000e+00 17 80415165 80415166 2 + 0.192 0.196 0.031
ENSG00000173818 E005 3.7200283 0.0561149800 9.258749e-01 9.573264e-01 17 80415167 80415177 11 + 0.638 0.621 -0.072
ENSG00000173818 E006 17.8267439 0.0103652002 7.315252e-01 8.231630e-01 17 80415178 80415183 6 + 1.174 1.205 0.110
ENSG00000173818 E007 20.2810312 0.0190991844 8.109149e-01 8.800671e-01 17 80415184 80415185 2 + 1.234 1.254 0.071
ENSG00000173818 E008 40.0021767 0.0005625286 9.188046e-01 9.527146e-01 17 80415186 80415197 12 + 1.530 1.533 0.010
ENSG00000173818 E009 65.3098827 0.0003857002 2.953640e-01 4.364967e-01 17 80415198 80415250 53 + 1.699 1.749 0.170
ENSG00000173818 E010 8.5727825 0.0025404327 3.653568e-02 8.459825e-02 17 80415315 80415451 137 + 1.084 0.839 -0.918
ENSG00000173818 E011 3.0247466 0.0052528063 4.696355e-01 6.088693e-01 17 80415452 80415452 1 + 0.638 0.516 -0.551
ENSG00000173818 E012 2.8764535 0.0053058642 3.818975e-01 5.261541e-01 17 80415453 80415454 2 + 0.638 0.490 -0.676
ENSG00000173818 E013 2.8764535 0.0053058642 3.818975e-01 5.261541e-01 17 80415455 80415457 3 + 0.638 0.490 -0.676
ENSG00000173818 E014 4.4910409 0.0036544454 7.670834e-01 8.494060e-01 17 80415458 80415468 11 + 0.638 0.681 0.186
ENSG00000173818 E015 6.4356154 0.0026835933 9.214865e-01 9.544351e-01 17 80415469 80415475 7 + 0.818 0.801 -0.066
ENSG00000173818 E016 15.6498334 0.0011328331 2.131472e-02 5.425319e-02 17 80415476 80415486 11 + 1.300 1.087 -0.756
ENSG00000173818 E017 34.2428318 0.0006151970 2.649467e-01 4.029524e-01 17 80415487 80415518 32 + 1.523 1.444 -0.269
ENSG00000173818 E018 47.1977753 0.0124355576 2.851969e-01 4.255044e-01 17 80415519 80415610 92 + 1.669 1.579 -0.304
ENSG00000173818 E019 32.3698438 0.0388282594 9.532557e-01 9.747631e-01 17 80415611 80415649 39 + 1.451 1.437 -0.048
ENSG00000173818 E020 84.4979707 0.0055807960 1.276539e-01 2.308834e-01 17 80415650 80415652 3 + 1.778 1.864 0.288
ENSG00000173818 E021 93.3685963 0.0084170544 3.048102e-01 4.468350e-01 17 80415653 80415668 16 + 1.842 1.903 0.204
ENSG00000173818 E022 157.6044389 0.0005991578 6.254258e-01 7.415571e-01 17 80415669 80415821 153 + 2.129 2.109 -0.067
ENSG00000173818 E023 15.3861092 0.0018261176 6.121627e-04 2.577622e-03 17 80415822 80416253 432 + 1.357 1.045 -1.108
ENSG00000173818 E024 14.6702241 0.0013946331 1.774817e-01 2.979792e-01 17 80416940 80417145 206 + 0.996 1.138 0.516
ENSG00000173818 E025 10.0226051 0.0591491300 1.577231e-01 2.720931e-01 17 80417344 80417416 73 + 1.123 0.902 -0.813
ENSG00000173818 E026 13.3345778 0.0399714019 2.245839e-02 5.663535e-02 17 80417417 80417620 204 + 1.288 0.988 -1.078
ENSG00000173818 E027 15.4656886 0.0260594228 3.608759e-02 8.375520e-02 17 80417621 80417780 160 + 1.312 1.064 -0.882
ENSG00000173818 E028 11.2764166 0.0213200559 3.816445e-02 8.766569e-02 17 80417781 80417810 30 + 1.190 0.937 -0.921
ENSG00000173818 E029 22.6979245 0.0014443131 5.355006e-02 1.154653e-01 17 80417811 80417945 135 + 1.407 1.249 -0.549
ENSG00000173818 E030 24.5461225 0.0010678751 8.737958e-01 9.228890e-01 17 80417946 80418441 496 + 1.323 1.333 0.034
ENSG00000173818 E031 22.9327744 0.0008770290 2.186642e-02 5.540059e-02 17 80418442 80418837 396 + 1.434 1.253 -0.630
ENSG00000173818 E032 2.8753973 0.0072199724 1.865297e-02 4.856986e-02 17 80419586 80419720 135 + 0.779 0.402 -1.719
ENSG00000173818 E033 17.8079408 0.0040244770 9.252636e-03 2.691610e-02 17 80420050 80420533 484 + 1.367 1.132 -0.828
ENSG00000173818 E034 33.6001033 0.0006512590 3.608092e-02 8.374177e-02 17 80421828 80421962 135 + 1.335 1.487 0.525
ENSG00000173818 E035 7.1767056 0.0262445792 4.851922e-01 6.231067e-01 17 80422140 80422205 66 + 0.916 0.814 -0.394
ENSG00000173818 E036 103.3275040 0.0010255457 2.501465e-01 3.861060e-01 17 80422206 80422245 40 + 1.973 1.923 -0.169
ENSG00000173818 E037 105.9281331 0.0002889930 2.813605e-01 4.212602e-01 17 80423520 80423564 45 + 1.981 1.935 -0.153
ENSG00000173818 E038 133.6809906 0.0014811657 6.892139e-01 7.911353e-01 17 80423565 80423632 68 + 2.061 2.043 -0.060
ENSG00000173818 E039 13.4303512 0.0013282081 4.463973e-01 5.878895e-01 17 80423633 80423816 184 + 1.140 1.059 -0.292
ENSG00000173818 E040 12.1345834 0.0025427870 9.316655e-01 9.609486e-01 17 80424019 80424233 215 + 1.042 1.030 -0.047
ENSG00000173818 E041 9.1820515 0.0697863024 5.714952e-02 1.217220e-01 17 80424234 80424348 115 + 1.141 0.838 -1.126
ENSG00000173818 E042 130.2770803 0.0021010818 8.513238e-01 9.078107e-01 17 80425032 80425100 69 + 2.033 2.039 0.020
ENSG00000173818 E043 2.2025514 0.0067904577 8.335644e-01 8.957400e-01 17 80425459 80425491 33 + 0.427 0.462 0.186
ENSG00000173818 E044 81.8771330 0.0010798976 4.370763e-01 5.791093e-01 17 80425492 80425503 12 + 1.813 1.847 0.114
ENSG00000173818 E045 145.6727069 0.0006578929 2.203371e-01 3.508140e-01 17 80425504 80425620 117 + 2.053 2.093 0.136
ENSG00000173818 E046 3.0288967 0.0073150253 1.626564e-01 2.786145e-01 17 80427668 80427850 183 + 0.325 0.586 1.356
ENSG00000173818 E047 5.4538529 0.0072497183 8.706879e-01 9.208763e-01 17 80428445 80428595 151 + 0.737 0.759 0.089
ENSG00000173818 E048 105.9242883 0.0002994241 1.420105e-02 3.867998e-02 17 80428596 80428660 65 + 1.869 1.967 0.329
ENSG00000173818 E049 115.7725761 0.0003128634 6.847325e-03 2.082994e-02 17 80429773 80429831 59 + 1.901 2.004 0.349
ENSG00000173818 E050 156.6565433 0.0002456653 1.700584e-04 8.352880e-04 17 80429832 80430034 203 + 2.015 2.140 0.420
ENSG00000173818 E051 74.4998725 0.0004036009 4.940066e-03 1.576433e-02 17 80430035 80430040 6 + 1.684 1.822 0.466
ENSG00000173818 E052 161.9243475 0.0002864568 1.750097e-05 1.099707e-04 17 80430041 80430354 314 + 2.015 2.158 0.478
ENSG00000173818 E053 47.8623117 0.0007124441 1.028980e-25 1.202574e-23 17 80436133 80438086 1954 + 1.963 1.426 -1.824