ENSG00000173805

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000310778 ENSG00000173805 HEK293_OSMI2_2hA HEK293_TMG_2hB HAP1 protein_coding protein_coding 3.050552 4.882562 1.588788 0.4066067 0.03485267 -1.613611 0.3302304 0.3373244 0.2895297 0.14456703 0.11240981 -0.2135847 0.10851250 0.06476667 0.18496667 0.12020000 0.3658352 0.0095749 FALSE TRUE
ENST00000341193 ENSG00000173805 HEK293_OSMI2_2hA HEK293_TMG_2hB HAP1 protein_coding protein_coding 3.050552 4.882562 1.588788 0.4066067 0.03485267 -1.613611 0.7333174 1.2114292 0.2291569 0.18052489 0.06248386 -2.3525411 0.23311250 0.25326667 0.14610000 -0.10716667 0.4204026 0.0095749 FALSE TRUE
ENST00000347901 ENSG00000173805 HEK293_OSMI2_2hA HEK293_TMG_2hB HAP1 protein_coding protein_coding 3.050552 4.882562 1.588788 0.4066067 0.03485267 -1.613611 1.2524841 2.5482787 0.5124415 0.38905771 0.15563298 -2.2918320 0.38756667 0.51820000 0.31880000 -0.19940000 0.3162736 0.0095749 FALSE TRUE
ENST00000458656 ENSG00000173805 HEK293_OSMI2_2hA HEK293_TMG_2hB HAP1 protein_coding protein_coding 3.050552 4.882562 1.588788 0.4066067 0.03485267 -1.613611 0.1930907 0.2387158 0.1369265 0.04773101 0.08856273 -0.7594040 0.06322917 0.04930000 0.08553333 0.03623333 0.9244861 0.0095749 FALSE TRUE
MSTRG.14310.10 ENSG00000173805 HEK293_OSMI2_2hA HEK293_TMG_2hB HAP1 protein_coding   3.050552 4.882562 1.588788 0.4066067 0.03485267 -1.613611 0.3900244 0.2538507 0.3982195 0.07768214 0.07937189 0.6296233 0.15480833 0.05573333 0.25046667 0.19473333 0.0095749 0.0095749 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000173805 E001 0.4428904 0.4285631043 1.000000e+00 1.0000000000 17 41708133 41708176 44 - 0.001 0.133 8.249
ENSG00000173805 E002 2.3625996 0.0082444632 5.335718e-01 0.6657417954 17 41717742 41718026 285 - 0.542 0.432 -0.546
ENSG00000173805 E003 2.1797362 0.0241104280 8.842979e-01 0.9300629232 17 41720813 41722639 1827 - 0.457 0.431 -0.134
ENSG00000173805 E004 170.4922942 0.0008879221 3.020788e-06 0.0000225867 17 41722640 41724596 1957 - 1.988 2.142 0.516
ENSG00000173805 E005 24.6630255 0.0008105726 9.587346e-01 0.9781437664 17 41724597 41724765 169 - 1.293 1.299 0.021
ENSG00000173805 E006 22.2650386 0.0009414941 8.194892e-01 0.8860023730 17 41724766 41724829 64 - 1.235 1.257 0.078
ENSG00000173805 E007 33.4090243 0.0006536240 6.158946e-01 0.7340541475 17 41724830 41725003 174 - 1.391 1.430 0.134
ENSG00000173805 E008 26.2112520 0.0078331760 5.273594e-01 0.6604456337 17 41725004 41725154 151 - 1.265 1.329 0.223
ENSG00000173805 E009 16.7243926 0.0027735460 1.685294e-01 0.2862468252 17 41725859 41725897 39 - 1.014 1.166 0.549
ENSG00000173805 E010 19.5696311 0.0010501989 1.437144e-01 0.2530673741 17 41727053 41727144 92 - 1.307 1.180 -0.446
ENSG00000173805 E011 7.2065935 0.0030384638 2.101843e-03 0.0075394835 17 41727298 41727453 156 - 1.086 0.707 -1.450
ENSG00000173805 E012 11.4125386 0.0016518269 5.979607e-02 0.1262657713 17 41727762 41727836 75 - 1.148 0.946 -0.736
ENSG00000173805 E013 5.0636809 0.0090195427 4.272456e-03 0.0139063284 17 41727837 41727932 96 - 0.987 0.590 -1.589
ENSG00000173805 E014 21.5564233 0.0010776177 5.205764e-01 0.6545288979 17 41728201 41728331 131 - 1.293 1.239 -0.189
ENSG00000173805 E015 16.9841750 0.0011928745 2.317564e-01 0.3645368955 17 41731493 41731559 67 - 1.235 1.123 -0.397
ENSG00000173805 E016 27.9504094 0.0008021709 3.375232e-01 0.4814024766 17 41731638 41731743 106 - 1.413 1.342 -0.246
ENSG00000173805 E017 41.1380478 0.0017904215 1.423320e-01 0.2512213823 17 41731937 41732118 182 - 1.590 1.499 -0.313
ENSG00000173805 E018 26.2395254 0.0034409946 5.172544e-01 0.6516744434 17 41732230 41732394 165 - 1.369 1.318 -0.177
ENSG00000173805 E019 1.8454854 0.0080625434 6.499494e-01 0.7610730074 17 41732695 41732718 24 - 0.457 0.373 -0.453
ENSG00000173805 E020 16.3249726 0.0012237019 8.759603e-01 0.9243457853 17 41732719 41732798 80 - 1.148 1.134 -0.050
ENSG00000173805 E021 29.9054183 0.0037206696 2.714248e-01 0.4101868365 17 41734166 41734644 479 - 1.452 1.370 -0.284