ENSG00000173801

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000310706 ENSG00000173801 HEK293_OSMI2_2hA HEK293_TMG_2hB JUP protein_coding protein_coding 29.94991 48.92926 18.09592 1.936504 0.6404576 -1.434531 15.0306983 25.8293177 8.424209 1.19128829 0.3520228 -1.615243 0.49860833 0.5276667 0.46546667 -0.06220000 7.012912e-02 1.660293e-05 FALSE  
ENST00000393931 ENSG00000173801 HEK293_OSMI2_2hA HEK293_TMG_2hB JUP protein_coding protein_coding 29.94991 48.92926 18.09592 1.936504 0.6404576 -1.434531 12.6646254 21.3177045 7.836685 0.75936546 0.5056237 -1.442574 0.41486667 0.4360000 0.43280000 -0.00320000 9.910241e-01 1.660293e-05 FALSE  
MSTRG.14314.5 ENSG00000173801 HEK293_OSMI2_2hA HEK293_TMG_2hB JUP protein_coding   29.94991 48.92926 18.09592 1.936504 0.6404576 -1.434531 0.6799648 0.2785075 1.037387 0.09380415 0.2199199 1.860113 0.02994583 0.0056000 0.05826667 0.05266667 1.660293e-05 1.660293e-05 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000173801 E001 0.6245948 0.0477147352 4.388255e-01 5.806683e-01 17 41754604 41754608 5 - 0.000 0.195 8.972
ENSG00000173801 E002 646.8955367 0.0037413557 2.192575e-10 3.643976e-09 17 41754609 41755024 416 - 2.546 2.765 0.732
ENSG00000173801 E003 404.7549100 0.0002067637 3.540717e-23 3.201806e-21 17 41755025 41755132 108 - 2.323 2.562 0.798
ENSG00000173801 E004 277.3759215 0.0017025689 2.029240e-09 2.836100e-08 17 41755133 41755179 47 - 2.187 2.396 0.700
ENSG00000173801 E005 441.1544360 0.0009299873 3.579800e-14 1.084918e-12 17 41755180 41755432 253 - 2.395 2.596 0.671
ENSG00000173801 E006 104.0414251 0.0003090691 3.695938e-02 8.538938e-02 17 41755433 41755515 83 - 1.859 1.952 0.315
ENSG00000173801 E007 184.6741567 0.0002709180 2.190765e-02 5.548655e-02 17 41755516 41755729 214 - 2.119 2.198 0.262
ENSG00000173801 E008 388.1761395 0.0008288837 1.542549e-01 2.674567e-01 17 41755730 41755895 166 - 2.471 2.512 0.138
ENSG00000173801 E009 201.9523890 0.0002260496 3.775636e-01 5.218984e-01 17 41756175 41756214 40 - 2.196 2.227 0.104
ENSG00000173801 E010 330.2977446 0.0001650214 7.180134e-01 8.132625e-01 17 41757415 41757536 122 - 2.423 2.436 0.043
ENSG00000173801 E011 297.3852774 0.0002661986 6.803737e-01 7.842747e-01 17 41757634 41757784 151 - 2.377 2.392 0.050
ENSG00000173801 E012 0.4741261 0.0209772085 1.289212e-01 2.326603e-01 17 41758172 41758398 227 - 0.328 0.075 -2.593
ENSG00000173801 E013 256.3476772 0.0001818171 7.441997e-01 8.326035e-01 17 41758399 41758518 120 - 2.313 2.326 0.044
ENSG00000173801 E014 320.3877245 0.0002059426 1.911609e-01 3.151816e-01 17 41758715 41758870 156 - 2.390 2.426 0.120
ENSG00000173801 E015 556.7915577 0.0001895740 1.508020e-01 2.627613e-01 17 41762983 41763321 339 - 2.674 2.653 -0.070
ENSG00000173801 E016 279.2817628 0.0001753055 7.259330e-04 2.992164e-03 17 41764713 41764816 104 - 2.419 2.340 -0.261
ENSG00000173801 E017 314.6651237 0.0014586109 3.321803e-04 1.509199e-03 17 41764923 41765067 145 - 2.486 2.389 -0.323
ENSG00000173801 E018 141.5929064 0.0033628536 4.264877e-03 1.388452e-02 17 41767379 41767394 16 - 2.157 2.039 -0.394
ENSG00000173801 E019 130.2580653 0.0027130106 1.194645e-03 4.622493e-03 17 41767395 41767400 6 - 2.130 1.999 -0.442
ENSG00000173801 E020 189.4595349 0.0010383697 5.736549e-05 3.184214e-04 17 41767401 41767457 57 - 2.286 2.161 -0.417
ENSG00000173801 E021 214.0340916 0.0037410950 1.350754e-01 2.411978e-01 17 41767458 41767580 123 - 2.285 2.232 -0.177
ENSG00000173801 E022 276.9819404 0.0030843594 7.045566e-02 1.440929e-01 17 41768969 41769207 239 - 2.400 2.343 -0.193
ENSG00000173801 E023 232.4396255 0.0002394346 2.861447e-06 2.151075e-05 17 41769418 41769573 156 - 2.371 2.251 -0.400
ENSG00000173801 E024 145.4470372 0.0002423960 3.308782e-05 1.947672e-04 17 41769574 41769625 52 - 2.180 2.047 -0.444
ENSG00000173801 E025 161.6217060 0.0002415106 3.905762e-06 2.846779e-05 17 41769626 41769677 52 - 2.229 2.089 -0.470
ENSG00000173801 E026 1.5479686 0.0098006108 2.038256e-01 3.309890e-01 17 41771417 41771646 230 - 0.513 0.287 -1.270
ENSG00000173801 E027 271.9173858 0.0019685094 2.269114e-08 2.618486e-07 17 41771647 41771846 200 - 2.475 2.306 -0.564
ENSG00000173801 E028 87.2783619 0.0029877572 1.110455e-07 1.118585e-06 17 41771847 41771859 13 - 2.042 1.794 -0.835
ENSG00000173801 E029 71.0114277 0.0057151689 1.742233e-04 8.536202e-04 17 41771860 41771862 3 - 1.928 1.717 -0.712
ENSG00000173801 E030 0.0000000       17 41772193 41772269 77 -      
ENSG00000173801 E031 7.9606551 0.0020724976 4.331042e-01 5.755532e-01 17 41772818 41772926 109 - 0.950 0.856 -0.357
ENSG00000173801 E032 0.1482932 0.0415972430 1.000000e+00   17 41784947 41785155 209 - 0.000 0.074 9.189
ENSG00000173801 E033 1.8424641 0.0088181540 7.253740e-01 8.186629e-01 17 41785903 41786209 307 - 0.329 0.398 0.409
ENSG00000173801 E034 0.6621601 0.0163933928 2.808367e-01 4.207121e-01 17 41786346 41786502 157 - 0.328 0.138 -1.593
ENSG00000173801 E035 6.2602523 0.0027555235 7.290858e-01 8.213696e-01 17 41786503 41786587 85 - 0.742 0.796 0.214
ENSG00000173801 E036 126.9152166 0.0071784009 2.006668e-06 1.560451e-05 17 41786588 41786765 178 - 2.198 1.955 -0.813
ENSG00000173801 E037 0.0000000       17 41786798 41786931 134 -