ENSG00000173757

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000293328 ENSG00000173757 HEK293_OSMI2_2hA HEK293_TMG_2hB STAT5B protein_coding protein_coding 16.08909 14.33064 16.47694 0.8111864 0.2512946 0.2012142 13.239751 13.2408435 13.103283 0.94456163 0.15711891 -0.0150553 0.82835000 0.92233333 0.79530000 -0.12703333 1.808857e-05 1.808857e-05 FALSE TRUE
ENST00000481517 ENSG00000173757 HEK293_OSMI2_2hA HEK293_TMG_2hB STAT5B protein_coding retained_intron 16.08909 14.33064 16.47694 0.8111864 0.2512946 0.2012142 1.213806 0.5362463 1.255464 0.06217209 0.06122248 1.2120426 0.07284583 0.03723333 0.07626667 0.03903333 1.031565e-02 1.808857e-05 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000173757 E001 389.1157059 0.0100402615 4.662850e-06 3.342653e-05 17 42199177 42200000 824 - 2.438 2.692 0.847
ENSG00000173757 E002 533.1753163 0.0020067518 1.577992e-06 1.254968e-05 17 42200001 42201263 1263 - 2.646 2.791 0.481
ENSG00000173757 E003 214.0570892 0.0002904140 1.900401e-01 3.138296e-01 17 42201264 42201532 269 - 2.300 2.362 0.208
ENSG00000173757 E004 207.0270892 0.0005975322 9.945414e-01 1.000000e+00 17 42201533 42201864 332 - 2.303 2.334 0.102
ENSG00000173757 E005 1.4059059 0.0096991504 3.071180e-01 4.493013e-01 17 42202103 42202339 237 - 0.463 0.302 -0.924
ENSG00000173757 E006 114.8227019 0.0037267430 1.367363e-01 2.435369e-01 17 42202340 42202447 108 - 2.084 2.051 -0.111
ENSG00000173757 E007 98.4388122 0.0023983390 2.638098e-01 4.017297e-01 17 42202757 42202808 52 - 2.009 1.993 -0.052
ENSG00000173757 E008 1.3254792 0.0104186191 4.707548e-01 6.099699e-01 17 42202809 42202953 145 - 0.412 0.302 -0.659
ENSG00000173757 E009 64.3251604 0.0004695260 2.503892e-01 3.864026e-01 17 42207558 42207558 1 - 1.828 1.807 -0.069
ENSG00000173757 E010 82.7270981 0.0003557573 3.540827e-01 4.983494e-01 17 42207559 42207581 23 - 1.928 1.922 -0.020
ENSG00000173757 E011 157.2600012 0.0003638836 2.808940e-01 4.207603e-01 17 42207582 42207728 147 - 2.199 2.198 -0.004
ENSG00000173757 E012 143.9507694 0.0007526443 7.568893e-01 8.418884e-01 17 42210171 42210301 131 - 2.148 2.168 0.065
ENSG00000173757 E013 1.5146591 0.1351134539 4.198058e-01 5.630585e-01 17 42210302 42210402 101 - 0.463 0.306 -0.896
ENSG00000173757 E014 60.8495788 0.0034990692 6.094931e-01 7.289905e-01 17 42210403 42210416 14 - 1.789 1.791 0.008
ENSG00000173757 E015 101.4223179 0.0080486783 5.055239e-01 6.412968e-01 17 42210417 42210497 81 - 2.014 2.004 -0.033
ENSG00000173757 E016 0.1515154 0.0439123867 4.856918e-01   17 42210498 42210592 95 - 0.120 0.000 -8.700
ENSG00000173757 E017 160.9398704 0.0056597540 9.256180e-01 9.571705e-01 17 42211984 42212190 207 - 2.193 2.223 0.101
ENSG00000173757 E018 105.7721088 0.0054156097 1.412017e-01 2.496825e-01 17 42216014 42216106 93 - 2.052 2.006 -0.155
ENSG00000173757 E019 126.8717141 0.0048909899 4.269878e-02 9.599436e-02 17 42217160 42217282 123 - 2.140 2.075 -0.217
ENSG00000173757 E020 109.5007629 0.0003179418 8.363957e-04 3.389072e-03 17 42217377 42217464 88 - 2.086 2.004 -0.277
ENSG00000173757 E021 11.3713659 0.0014810938 8.190051e-03 2.426544e-02 17 42217465 42217689 225 - 1.201 0.971 -0.834
ENSG00000173757 E022 12.5763772 0.0724509631 1.609350e-01 2.763406e-01 17 42217690 42218150 461 - 1.228 1.035 -0.695
ENSG00000173757 E023 125.5942045 0.0003390346 3.495728e-06 2.579377e-05 17 42218151 42218330 180 - 2.163 2.046 -0.390
ENSG00000173757 E024 62.2989457 0.0005335975 6.092461e-03 1.885422e-02 17 42218723 42218878 156 - 1.848 1.754 -0.314
ENSG00000173757 E025 37.4980372 0.0321266341 7.155617e-01 8.114510e-01 17 42219312 42219463 152 - 1.584 1.577 -0.024
ENSG00000173757 E026 17.2592032 0.0705005071 7.525441e-01 8.387047e-01 17 42219712 42219714 3 - 1.217 1.286 0.244
ENSG00000173757 E027 58.3658982 0.0140421265 4.376929e-01 5.796070e-01 17 42219715 42219842 128 - 1.786 1.755 -0.107
ENSG00000173757 E028 86.0625109 0.0022531682 1.762518e-02 4.632533e-02 17 42223382 42223462 81 - 1.975 1.900 -0.254
ENSG00000173757 E029 88.5524682 0.0050601905 1.393213e-02 3.806899e-02 17 42223463 42223556 94 - 1.998 1.901 -0.325
ENSG00000173757 E030 74.2701367 0.0054433122 1.964296e-01 3.217585e-01 17 42224779 42224868 90 - 1.895 1.853 -0.144
ENSG00000173757 E031 76.3455210 0.0004482201 1.769357e-02 4.647414e-02 17 42227529 42227657 129 - 1.921 1.855 -0.224
ENSG00000173757 E032 44.3603638 0.0064400232 3.593914e-03 1.199303e-02 17 42227658 42227685 28 - 1.734 1.574 -0.545
ENSG00000173757 E033 64.6105851 0.0069644890 2.190012e-02 5.547118e-02 17 42232000 42232137 138 - 1.868 1.763 -0.355
ENSG00000173757 E034 30.1791642 0.0124334479 1.375398e-01 2.446619e-01 17 42276248 42276406 159 - 1.539 1.448 -0.312
ENSG00000173757 E035 0.0000000       17 42276628 42276707 80 -