ENSG00000173727

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000309775 ENSG00000173727 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene processed_transcript 0.6886827 0.6099162 0.7691862 0.06691244 0.1945267 0.329895 0.05812779 0.03007919 0.0000000 0.030079192 0.00000000 -2.0028534 0.09201250 0.04703333 0.00000000 -0.04703333 6.309979e-01 8.404801e-06   FALSE
ENST00000619960 ENSG00000173727 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene processed_transcript 0.6886827 0.6099162 0.7691862 0.06691244 0.1945267 0.329895 0.21330240 0.35258700 0.1085945 0.074094773 0.10859453 -1.6122897 0.30725417 0.56893333 0.09386667 -0.47506667 9.373427e-02 8.404801e-06   FALSE
ENST00000637245 ENSG00000173727 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene transcribed_unprocessed_pseudogene 0.6886827 0.6099162 0.7691862 0.06691244 0.1945267 0.329895 0.07355209 0.00000000 0.3501997 0.000000000 0.09401479 5.1707249 0.09107500 0.00000000 0.45673333 0.45673333 8.404801e-06 8.404801e-06 FALSE FALSE
ENST00000637877 ENSG00000173727 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene processed_transcript 0.6886827 0.6099162 0.7691862 0.06691244 0.1945267 0.329895 0.04123082 0.00000000 0.0000000 0.000000000 0.00000000 0.0000000 0.05917917 0.00000000 0.00000000 0.00000000   8.404801e-06   FALSE
ENST00000685970 ENSG00000173727 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene processed_transcript 0.6886827 0.6099162 0.7691862 0.06691244 0.1945267 0.329895 0.30246957 0.22724999 0.3103920 0.008274786 0.03649252 0.4334303 0.45047917 0.38400000 0.44936667 0.06536667 9.262120e-01 8.404801e-06   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000173727 E001 0.1472490 0.047830317 0.408749940   11 65455257 65455257 1 + 0.137 0.000 -9.921
ENSG00000173727 E002 0.4407149 0.023961546 0.465559431 0.605233330 11 65455258 65455266 9 + 0.241 0.109 -1.387
ENSG00000173727 E003 0.5858876 0.020577977 0.233810159 0.366914341 11 65455267 65455285 19 + 0.325 0.109 -1.972
ENSG00000173727 E004 1.9070978 0.009417010 0.520436921 0.654395905 11 65455286 65455312 27 + 0.396 0.476 0.424
ENSG00000173727 E005 2.8828979 0.010356025 0.895821220 0.937430142 11 65455313 65455331 19 + 0.599 0.552 -0.214
ENSG00000173727 E006 2.6842548 0.006416624 0.714604782 0.810743813 11 65455437 65455581 145 + 0.599 0.516 -0.384
ENSG00000173727 E007 2.2069065 0.007437581 0.590049783 0.712993959 11 65455694 65455819 126 + 0.456 0.516 0.294
ENSG00000173727 E008 6.2475840 0.003610845 0.215680956 0.345217683 11 65455820 65456300 481 + 0.793 0.894 0.392
ENSG00000173727 E009 1.3586869 0.011338008 0.042058807 0.094836935 11 65456301 65456318 18 + 0.137 0.476 2.421
ENSG00000173727 E010 3.9020249 0.004308681 0.638746037 0.752330010 11 65456319 65456610 292 + 0.737 0.645 -0.385
ENSG00000173727 E011 0.5202097 0.024990628 0.463503076 0.603305237 11 65456611 65456637 27 + 0.242 0.109 -1.383
ENSG00000173727 E012 1.0330470 0.012582386 0.001511282 0.005672831 11 65456638 65456871 234 + 0.557 0.000 -13.985
ENSG00000173727 E013 0.2965864 0.140534573 0.287948807   11 65466085 65466720 636 + 0.000 0.193 10.997