ENSG00000173698

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356606 ENSG00000173698 HEK293_OSMI2_2hA HEK293_TMG_2hB ADGRG2 protein_coding protein_coding 0.3600087 0.2477024 0.6614533 0.04181773 0.01696948 1.381581 0.03788836 0.00000000 0.00000000 0.00000000 0.0000000 0.000000 0.09768333 0.0000000 0.00000000 0.00000000   0.01032505 FALSE TRUE
ENST00000357544 ENSG00000173698 HEK293_OSMI2_2hA HEK293_TMG_2hB ADGRG2 protein_coding protein_coding 0.3600087 0.2477024 0.6614533 0.04181773 0.01696948 1.381581 0.05706134 0.00000000 0.26149262 0.00000000 0.1324614 4.762841 0.15066250 0.0000000 0.40453333 0.40453333 0.35661875 0.01032505 FALSE TRUE
ENST00000357991 ENSG00000173698 HEK293_OSMI2_2hA HEK293_TMG_2hB ADGRG2 protein_coding protein_coding 0.3600087 0.2477024 0.6614533 0.04181773 0.01696948 1.381581 0.05849030 0.00000000 0.05357610 0.00000000 0.0535761 2.668484 0.12135000 0.0000000 0.08513333 0.08513333 0.99087909 0.01032505 FALSE TRUE
ENST00000379873 ENSG00000173698 HEK293_OSMI2_2hA HEK293_TMG_2hB ADGRG2 protein_coding protein_coding 0.3600087 0.2477024 0.6614533 0.04181773 0.01696948 1.381581 0.08468379 0.20447809 0.08433968 0.01328148 0.0688778 -1.184894 0.28901250 0.8580667 0.12420000 -0.73386667 0.01032505 0.01032505 FALSE TRUE
ENST00000379876 ENSG00000173698 HEK293_OSMI2_2hA HEK293_TMG_2hB ADGRG2 protein_coding protein_coding 0.3600087 0.2477024 0.6614533 0.04181773 0.01696948 1.381581 0.06770317 0.00000000 0.25017418 0.00000000 0.1340969 4.701406 0.14447500 0.0000000 0.36820000 0.36820000 0.37140896 0.01032505 FALSE TRUE
ENST00000379878 ENSG00000173698 HEK293_OSMI2_2hA HEK293_TMG_2hB ADGRG2 protein_coding protein_coding 0.3600087 0.2477024 0.6614533 0.04181773 0.01696948 1.381581 0.01371751 0.03334026 0.00000000 0.03334026 0.0000000 -2.115708 0.05167917 0.1033667 0.00000000 -0.10336667 0.45617435 0.01032505 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000173698 E001 0.0000000       X 18989307 18989308 2 -      
ENSG00000173698 E002 0.0000000       X 18989309 18989313 5 -      
ENSG00000173698 E003 0.0000000       X 18989314 18989314 1 -      
ENSG00000173698 E004 9.2495217 0.003760207 0.0001858896 0.000903096 X 18989315 18990009 695 - 0.833 1.212 1.394
ENSG00000173698 E005 15.6824844 0.007268836 0.2568828147 0.393900983 X 18990010 18991048 1039 - 1.157 1.254 0.341
ENSG00000173698 E006 3.6029043 0.005625880 0.0041648500 0.013605406 X 18994896 18995048 153 - 0.737 0.189 -3.028
ENSG00000173698 E007 5.2360300 0.008438601 0.4581436736 0.598467489 X 18996051 18996152 102 - 0.795 0.684 -0.452
ENSG00000173698 E008 7.4203525 0.002880303 0.3976818821 0.541435303 X 18998996 18999279 284 - 0.922 0.811 -0.430
ENSG00000173698 E009 3.4429673 0.005397267 0.3912015772 0.535131488 X 18999861 18999960 100 - 0.652 0.503 -0.674
ENSG00000173698 E010 4.0477813 0.022286711 0.8928169686 0.935496428 X 19002846 19003114 269 - 0.671 0.683 0.051
ENSG00000173698 E011 1.9260163 0.116820360 0.8119095448 0.880672340 X 19004758 19004879 122 - 0.468 0.416 -0.269
ENSG00000173698 E012 2.2228167 0.006827230 0.8231028488 0.888504777 X 19006002 19006105 104 - 0.468 0.503 0.174
ENSG00000173698 E013 2.0619518 0.012203466 0.8183961618 0.885209638 X 19006220 19006265 46 - 0.468 0.422 -0.240
ENSG00000173698 E014 2.9423375 0.007102675 0.6220044123 0.738877170 X 19007235 19007357 123 - 0.592 0.503 -0.411
ENSG00000173698 E015 3.3924905 0.006449328 0.3913377000 0.535244262 X 19007980 19008123 144 - 0.652 0.503 -0.674
ENSG00000173698 E016 4.5759070 0.008485252 0.2296613732 0.362035133 X 19009626 19009782 157 - 0.767 0.572 -0.827
ENSG00000173698 E017 4.6384750 0.004360174 0.7422154877 0.831169669 X 19010613 19010778 166 - 0.737 0.683 -0.221
ENSG00000173698 E018 6.2197661 0.002886464 0.1620120429 0.277741842 X 19013686 19014074 389 - 0.767 0.937 0.659
ENSG00000173698 E019 0.0000000       X 19019568 19019598 31 -      
ENSG00000173698 E020 2.6896697 0.007038944 0.8200926144 0.886472664 X 19019599 19019665 67 - 0.546 0.503 -0.204
ENSG00000173698 E021 1.6888774 0.008838109 0.5418704563 0.672766524 X 19021104 19021198 95 - 0.438 0.321 -0.674
ENSG00000173698 E022 2.0486010 0.011109296 0.3654512877 0.509764386 X 19023416 19023453 38 - 0.496 0.321 -0.963
ENSG00000173698 E023 2.7849573 0.045576632 0.7290129414 0.821321966 X 19023909 19023948 40 - 0.522 0.574 0.241
ENSG00000173698 E024 2.7441592 0.009731232 0.8297468580 0.893127123 X 19027219 19027274 56 - 0.547 0.504 -0.203
ENSG00000173698 E025 1.4822801 0.010515105 0.8015470185 0.873542399 X 19028183 19028238 56 - 0.372 0.321 -0.310
ENSG00000173698 E026 1.5803225 0.107528256 0.2742971893 0.413436070 X 19030984 19031037 54 - 0.294 0.510 1.207
ENSG00000173698 E027 0.1515154 0.043158798 1.0000000000   X 19031038 19033612 2575 - 0.077 0.000 -8.997
ENSG00000173698 E028 0.8470867 0.014656557 0.4947538145 0.631656587 X 19033613 19033654 42 - 0.199 0.321 0.912
ENSG00000173698 E029 0.1472490 0.045237853 1.0000000000   X 19033655 19035941 2287 - 0.077 0.000 -8.995
ENSG00000173698 E030 0.6299079 0.019444692 1.0000000000 1.000000000 X 19035942 19035977 36 - 0.199 0.189 -0.089
ENSG00000173698 E031 0.0000000       X 19035978 19036388 411 -      
ENSG00000173698 E032 0.4847352 0.154605958 0.7681813338 0.850231980 X 19037467 19037490 24 - 0.143 0.190 0.495
ENSG00000173698 E033 0.0000000       X 19037589 19037597 9 -      
ENSG00000173698 E034 0.1515154 0.043158798 1.0000000000   X 19037598 19037636 39 - 0.077 0.000 -8.997
ENSG00000173698 E035 0.8857980 0.014234321 0.1177820476 0.216765971 X 19040189 19040224 36 - 0.335 0.000 -11.138
ENSG00000173698 E036 1.7788691 0.008134445 0.1214263402 0.221963526 X 19068717 19068835 119 - 0.496 0.189 -1.965
ENSG00000173698 E037 0.5985731 0.020606761 1.0000000000 1.000000000 X 19082702 19082746 45 - 0.199 0.189 -0.092
ENSG00000173698 E038 0.4427912 0.256202292 0.7656443923 0.848349104 X 19122442 19122637 196 - 0.142 0.187 0.476