ENSG00000173660

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000311672 ENSG00000173660 HEK293_OSMI2_2hA HEK293_TMG_2hB UQCRH protein_coding protein_coding 1215.159 1999.057 858.3937 356.5752 1.938735 -1.219598 828.92016 1415.5148 491.48713 300.77318 10.68810 -1.5260822 0.65774583 0.69850000 0.57260000 -0.1259 0.01667977 4.832933e-11   TRUE
MSTRG.1107.4 ENSG00000173660 HEK293_OSMI2_2hA HEK293_TMG_2hB UQCRH protein_coding   1215.159 1999.057 858.3937 356.5752 1.938735 -1.219598 73.51866 123.6333 43.24637 12.93634 2.22510 -1.5152001 0.06032083 0.06366667 0.05036667 -0.0133 0.28307210 4.832933e-11   TRUE
MSTRG.1107.7 ENSG00000173660 HEK293_OSMI2_2hA HEK293_TMG_2hB UQCRH protein_coding   1215.159 1999.057 858.3937 356.5752 1.938735 -1.219598 239.22633 357.7943 245.89325 24.55958 12.58906 -0.5410799 0.21837500 0.18690000 0.28640000 0.0995 0.03577183 4.832933e-11   TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000173660 E001 0.1817044 4.274366e-02 1.000000e+00   1 46300385 46300697 313 + 0.001 0.078 7.219
ENSG00000173660 E002 35.2192570 2.070307e+00 2.984437e-01 4.398882e-01 1 46303333 46303377 45 + 1.809 1.312 -1.700
ENSG00000173660 E003 1.4362071 2.305621e-01 6.528701e-01 7.634958e-01 1 46303618 46303632 15 + 0.418 0.304 -0.671
ENSG00000173660 E004 528.6503253 5.211380e-03 1.263211e-01 2.290304e-01 1 46303633 46303697 65 + 2.615 2.663 0.160
ENSG00000173660 E005 694.1664344 2.285953e-03 6.584258e-01 7.675729e-01 1 46303698 46303706 9 + 2.768 2.773 0.017
ENSG00000173660 E006 1249.4457246 2.676514e-04 4.730345e-01 6.120489e-01 1 46303707 46303708 2 + 3.036 3.032 -0.015
ENSG00000173660 E007 2892.9222818 3.357922e-04 1.449781e-04 7.253509e-04 1 46303709 46303721 13 + 3.423 3.386 -0.125
ENSG00000173660 E008 4756.9872757 5.649223e-05 2.644189e-08 3.010600e-07 1 46303722 46303748 27 + 3.636 3.607 -0.094
ENSG00000173660 E009 6777.0939722 8.926269e-05 4.238871e-02 9.542634e-02 1 46303749 46303820 72 + 3.772 3.763 -0.029
ENSG00000173660 E010 4083.6247766 2.281315e-04 2.819328e-04 1.306315e-03 1 46309101 46309103 3 + 3.568 3.536 -0.106
ENSG00000173660 E011 6123.0043484 4.947098e-05 5.663230e-04 2.407724e-03 1 46309104 46309127 24 + 3.703 3.730 0.091
ENSG00000173660 E012 211.9852757 3.730669e-03 9.933894e-01 1.000000e+00 1 46309128 46309143 16 + 2.262 2.260 -0.008
ENSG00000173660 E013 41.0353332 1.154205e-02 7.382484e-15 2.481969e-13 1 46309144 46309673 530 + 1.921 1.333 -2.005
ENSG00000173660 E014 234.8692535 3.552194e-03 7.792971e-26 9.204208e-24 1 46309897 46309900 4 + 2.570 2.179 -1.305
ENSG00000173660 E015 284.2419063 5.795687e-03 1.202333e-20 8.310048e-19 1 46309901 46309920 20 + 2.655 2.257 -1.326
ENSG00000173660 E016 456.5536093 5.725545e-03 5.895437e-19 3.336937e-17 1 46309921 46310044 124 + 2.837 2.476 -1.202
ENSG00000173660 E017 121.6937507 1.455948e-03 1.246041e-02 3.464320e-02 1 46310045 46310154 110 + 2.094 2.001 -0.312
ENSG00000173660 E018 9611.7247915 1.176981e-04 2.769255e-19 1.628265e-17 1 46310155 46310316 162 + 3.873 3.927 0.179
ENSG00000173660 E019 5539.0197882 8.828795e-04 9.890979e-08 1.005212e-06 1 46316552 46316776 225 + 3.613 3.689 0.251
ENSG00000173660 E020 0.8146179 5.526367e-02 1.882799e-01 3.115719e-01 1 46334601 46334650 50 + 0.000 0.296 10.749