ENSG00000173638

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000311124 ENSG00000173638 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC19A1 protein_coding protein_coding 55.34115 70.13775 47.351 4.872395 1.118209 -0.5666974 34.722129 56.550324 23.216488 2.448005 0.3857011 -1.2840194 0.61141250 0.80986667 0.4905667 -0.31930000 9.367565e-08 9.367565e-08 FALSE TRUE
ENST00000380010 ENSG00000173638 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC19A1 protein_coding protein_coding 55.34115 70.13775 47.351 4.872395 1.118209 -0.5666974 7.606449 1.015930 10.938309 1.015930 0.8415045 3.4157042 0.14891667 0.01406667 0.2308333 0.21676667 2.144163e-02 9.367565e-08 FALSE TRUE
ENST00000485649 ENSG00000173638 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC19A1 protein_coding protein_coding 55.34115 70.13775 47.351 4.872395 1.118209 -0.5666974 5.202824 3.356921 6.149303 1.494583 0.8143663 0.8713372 0.09837917 0.04543333 0.1295667 0.08413333 2.320933e-01 9.367565e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000173638 E001 0.4418608 0.0312083575 1.650338e-02 4.385078e-02 21 45493572 45496379 2808 - 0.399 0.000 -12.804
ENSG00000173638 E002 0.0000000       21 45498201 45498345 145 -      
ENSG00000173638 E003 0.2987644 0.0269578830 5.958559e-02   21 45498346 45498612 267 - 0.302 0.000 -14.288
ENSG00000173638 E004 0.1472490 0.0427846725 2.199928e-01   21 45502311 45502512 202 - 0.177 0.000 -13.012
ENSG00000173638 E005 12.0222174 0.0080317967 6.409435e-13 1.624195e-11 21 45502513 45502969 457 - 1.480 0.716 -2.796
ENSG00000173638 E006 2.8119135 0.0051805266 5.648061e-05 3.140248e-04 21 45503933 45504121 189 - 0.905 0.265 -3.063
ENSG00000173638 E007 13.1341043 0.0016315030 8.901077e-01 9.337907e-01 21 45512362 45512564 203 - 1.099 1.085 -0.051
ENSG00000173638 E008 228.6400372 0.0040922778 3.162774e-04 1.445739e-03 21 45512565 45512824 260 - 2.207 2.330 0.414
ENSG00000173638 E009 210.5301162 0.0065721680 1.000528e-03 3.960117e-03 21 45512825 45512898 74 - 2.161 2.297 0.456
ENSG00000173638 E010 373.4410723 0.0028081400 5.547699e-05 3.090525e-04 21 45512899 45513178 280 - 2.433 2.540 0.356
ENSG00000173638 E011 112.6481199 0.0002688077 4.461480e-02 9.949178e-02 21 45513179 45513187 9 - 1.962 2.007 0.153
ENSG00000173638 E012 298.1868995 0.0027482493 3.610903e-05 2.103551e-04 21 45513188 45513418 231 - 2.328 2.445 0.389
ENSG00000173638 E013 201.7051060 0.0065533988 1.864446e-02 4.855304e-02 21 45513419 45513558 140 - 2.182 2.270 0.294
ENSG00000173638 E014 801.7046278 0.0017870320 8.486734e-02 1.671921e-01 21 45513559 45514638 1080 - 2.836 2.849 0.044
ENSG00000173638 E015 115.0820159 0.0024213319 5.385412e-01 6.699539e-01 21 45514639 45514670 32 - 2.009 2.006 -0.010
ENSG00000173638 E016 137.2190326 0.0030085472 5.526914e-01 6.819399e-01 21 45514671 45514714 44 - 2.118 2.065 -0.179
ENSG00000173638 E017 551.1452387 0.0031814708 3.110886e-03 1.059254e-02 21 45514715 45514895 181 - 2.633 2.700 0.224
ENSG00000173638 E018 1145.0594082 0.0032927790 5.126758e-06 3.639681e-05 21 45514896 45515152 257 - 2.921 3.025 0.346
ENSG00000173638 E019 1253.9814524 0.0001102707 2.101288e-41 7.961655e-39 21 45515153 45515517 365 - 2.935 3.068 0.440
ENSG00000173638 E020 628.9385971 0.0001082863 3.887239e-16 1.549392e-14 21 45515518 45515639 122 - 2.657 2.762 0.349
ENSG00000173638 E021 1410.1179767 0.0002612079 3.062120e-04 1.404623e-03 21 45515640 45516140 501 - 3.077 3.091 0.049
ENSG00000173638 E022 606.1603104 0.0014804478 2.401170e-08 2.755920e-07 21 45525817 45525958 142 - 2.833 2.676 -0.525
ENSG00000173638 E023 542.0632935 0.0024887391 4.118215e-09 5.446307e-08 21 45530770 45530971 202 - 2.809 2.616 -0.642
ENSG00000173638 E024 830.1486209 0.0060056028 4.992567e-05 2.814123e-04 21 45531389 45531790 402 - 2.984 2.808 -0.586
ENSG00000173638 E025 311.2657771 0.0032366735 2.107838e-06 1.631290e-05 21 45531791 45531873 83 - 2.566 2.376 -0.634
ENSG00000173638 E026 592.3223990 0.0024285740 1.144061e-09 1.677546e-08 21 45531874 45532148 275 - 2.848 2.654 -0.647
ENSG00000173638 E027 4.3522756 0.0685457644 3.004081e-01 4.420853e-01 21 45534538 45534706 169 - 0.815 0.603 -0.879
ENSG00000173638 E028 9.3268216 0.0184458680 2.691148e-01 4.075791e-01 21 45535984 45536528 545 - 1.081 0.921 -0.594
ENSG00000173638 E029 14.7026171 0.0012608557 3.209501e-02 7.604180e-02 21 45537767 45537770 4 - 1.292 1.070 -0.793
ENSG00000173638 E030 225.0987665 0.0045842737 2.771716e-08 3.141449e-07 21 45537771 45537777 7 - 2.468 2.212 -0.852
ENSG00000173638 E031 558.5681974 0.0048731633 6.478037e-09 8.276536e-08 21 45537778 45538008 231 - 2.851 2.614 -0.788
ENSG00000173638 E032 17.6183840 0.0161814363 2.012290e-01 3.277274e-01 21 45541455 45541711 257 - 1.325 1.162 -0.574
ENSG00000173638 E033 9.2294809 0.0118042813 6.045140e-01 7.250379e-01 21 45541787 45541838 52 - 1.023 0.934 -0.334
ENSG00000173638 E034 14.3733721 0.0069284897 4.446500e-02 9.923148e-02 21 45542260 45542367 108 - 1.281 1.055 -0.805
ENSG00000173638 E035 179.2511624 0.0119215959 1.541389e-03 5.769974e-03 21 45542368 45542471 104 - 2.345 2.130 -0.720
ENSG00000173638 E036 0.0000000       21 45543777 45543859 83 -      
ENSG00000173638 E037 0.1451727 0.0434149335 2.197576e-01   21 45544137 45544411 275 - 0.177 0.000 -13.003
ENSG00000173638 E038 0.0000000       21 45562221 45562741 521 -      
ENSG00000173638 E039 0.0000000       21 45562742 45562957 216 -      
ENSG00000173638 E040 0.0000000       21 45562958 45563115 158 -      
ENSG00000173638 E041 0.0000000       21 45573241 45573365 125 -