ENSG00000173517

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000312493 ENSG00000173517 HEK293_OSMI2_2hA HEK293_TMG_2hB PEAK1 protein_coding protein_coding 5.341113 3.157141 6.848866 0.5117902 0.6583094 1.114789 2.7242057 1.4861063 3.1488709 0.30552132 0.51397097 1.0781963 0.53742500 0.47313333 0.45443333 -0.01870000 0.98001141 0.004546399 FALSE TRUE
ENST00000569692 ENSG00000173517 HEK293_OSMI2_2hA HEK293_TMG_2hB PEAK1 protein_coding processed_transcript 5.341113 3.157141 6.848866 0.5117902 0.6583094 1.114789 0.1060712 0.3722870 0.1530228 0.09021688 0.07704546 -1.2295824 0.02794167 0.11633333 0.02040000 -0.09593333 0.02073974 0.004546399   FALSE
ENST00000682557 ENSG00000173517 HEK293_OSMI2_2hA HEK293_TMG_2hB PEAK1 protein_coding protein_coding 5.341113 3.157141 6.848866 0.5117902 0.6583094 1.114789 0.3398176 0.6097272 0.5126829 0.11788388 0.31218798 -0.2456975 0.07727500 0.19560000 0.08556667 -0.11003333 0.47699933 0.004546399 FALSE TRUE
MSTRG.11281.15 ENSG00000173517 HEK293_OSMI2_2hA HEK293_TMG_2hB PEAK1 protein_coding   5.341113 3.157141 6.848866 0.5117902 0.6583094 1.114789 0.1612789 0.0000000 0.4041132 0.00000000 0.40411317 5.3719532 0.02385417 0.00000000 0.05316667 0.05316667 0.93414295 0.004546399   FALSE
MSTRG.11281.16 ENSG00000173517 HEK293_OSMI2_2hA HEK293_TMG_2hB PEAK1 protein_coding   5.341113 3.157141 6.848866 0.5117902 0.6583094 1.114789 0.4981678 0.4402984 0.6362735 0.17607189 0.17583997 0.5212636 0.08590417 0.13053333 0.09393333 -0.03660000 0.69304068 0.004546399   FALSE
MSTRG.11281.3 ENSG00000173517 HEK293_OSMI2_2hA HEK293_TMG_2hB PEAK1 protein_coding   5.341113 3.157141 6.848866 0.5117902 0.6583094 1.114789 0.4793932 0.1315401 0.5331159 0.05016606 0.30884779 1.9400493 0.08381667 0.04676667 0.08823333 0.04146667 0.99486298 0.004546399 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000173517 E001 13.6243232 0.008258229 4.267749e-02 9.595559e-02 15 77100656 77108157 7502 - 1.046 1.270 0.800
ENSG00000173517 E002 0.4751703 0.020525065 3.028974e-01 4.448226e-01 15 77108158 77108163 6 - 0.094 0.274 1.865
ENSG00000173517 E003 660.9522609 0.002016160 1.971164e-14 6.212461e-13 15 77108164 77115040 6877 - 2.753 2.886 0.442
ENSG00000173517 E004 37.2168051 0.007405269 3.578184e-03 1.195022e-02 15 77115041 77115319 279 - 1.633 1.446 -0.639
ENSG00000173517 E005 74.5835478 0.003912680 1.146481e-05 7.515482e-05 15 77133005 77133750 746 - 1.937 1.738 -0.672
ENSG00000173517 E006 0.3299976 0.027442404 9.148030e-02   15 77155200 77158502 3303 - 0.000 0.274 11.796
ENSG00000173517 E007 25.1233157 0.016201581 4.796815e-04 2.082265e-03 15 77158503 77158696 194 - 1.506 1.192 -1.092
ENSG00000173517 E008 0.0000000       15 77177819 77177855 37 -      
ENSG00000173517 E009 0.0000000       15 77177856 77178023 168 -      
ENSG00000173517 E010 0.0000000       15 77178024 77178789 766 -      
ENSG00000173517 E011 91.3538595 0.008251428 9.274474e-06 6.211629e-05 15 77178790 77179957 1168 - 2.028 1.807 -0.743
ENSG00000173517 E012 141.2214729 0.002922657 9.403607e-03 2.729032e-02 15 77179958 77181746 1789 - 2.167 2.098 -0.231
ENSG00000173517 E013 27.3240437 0.002658571 2.649896e-01 4.029950e-01 15 77181747 77181978 232 - 1.455 1.402 -0.181
ENSG00000173517 E014 15.6933286 0.005465642 9.810579e-01 9.921712e-01 15 77181979 77182040 62 - 1.196 1.227 0.109
ENSG00000173517 E015 1.3973731 0.114742679 8.771302e-01 9.250973e-01 15 77239782 77239889 108 - 0.388 0.364 -0.138
ENSG00000173517 E016 13.5719439 0.001405457 9.336537e-01 9.622048e-01 15 77252367 77252421 55 - 1.147 1.165 0.066
ENSG00000173517 E017 14.6510849 0.001414689 9.289399e-01 9.593123e-01 15 77252422 77252478 57 - 1.169 1.203 0.121
ENSG00000173517 E018 11.8301651 0.012143816 4.758547e-01 6.145310e-01 15 77252479 77252498 20 - 1.116 1.063 -0.190
ENSG00000173517 E019 11.2485454 0.005446735 3.205700e-01 4.637134e-01 15 77252499 77252526 28 - 1.108 1.028 -0.289
ENSG00000173517 E020 0.0000000       15 77252527 77252531 5 -      
ENSG00000173517 E021 0.0000000       15 77255449 77255552 104 -      
ENSG00000173517 E022 0.3686942 0.030435299 6.931994e-01 7.942552e-01 15 77283762 77283882 121 - 0.094 0.158 0.869
ENSG00000173517 E023 8.7893938 0.002156994 6.496655e-01 7.608657e-01 15 77283883 77284030 148 - 0.996 0.971 -0.096
ENSG00000173517 E024 8.8386040 0.003151850 8.863229e-03 2.594065e-02 15 77284958 77285055 98 - 1.082 0.797 -1.074
ENSG00000173517 E025 4.9609824 0.012476181 8.796955e-01 9.267839e-01 15 77285056 77285078 23 - 0.765 0.766 0.006
ENSG00000173517 E026 0.7665583 0.084124684 1.339035e-02 3.682283e-02 15 77285079 77285100 22 - 0.000 0.443 12.433
ENSG00000173517 E027 13.9654173 0.014111432 7.542813e-01 8.399759e-01 15 77286423 77286504 82 - 1.169 1.165 -0.012
ENSG00000173517 E028 0.9974562 0.012262957 5.173553e-01 6.517582e-01 15 77346542 77346631 90 - 0.236 0.365 0.866
ENSG00000173517 E029 4.0710569 0.006465767 1.355349e-01 2.418610e-01 15 77361315 77361431 117 - 0.590 0.827 0.982
ENSG00000173517 E030 12.1562710 0.001985830 4.121471e-01 5.556942e-01 15 77365163 77365225 63 - 1.074 1.178 0.373
ENSG00000173517 E031 10.8890352 0.079498338 4.265836e-01 5.693962e-01 15 77420006 77420144 139 - 1.115 1.002 -0.412
ENSG00000173517 E032 1.7327829 0.008122358 9.715128e-01 9.861874e-01 15 77420676 77420820 145 - 0.429 0.440 0.058