ENSG00000173482

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000332175 ENSG00000173482 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPRM protein_coding protein_coding 2.423455 1.496829 3.229052 0.2705513 0.4566745 1.104056 0.06176070 0.00000000 0.22203040 0.00000000 0.22203040 4.53624192 0.02839167 0.00000000 0.08883333 0.08883333 0.96678762 0.01511057 FALSE TRUE
ENST00000400053 ENSG00000173482 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPRM protein_coding protein_coding 2.423455 1.496829 3.229052 0.2705513 0.4566745 1.104056 0.77662029 0.68598076 0.63292647 0.17100057 0.40790621 -0.11439367 0.32753333 0.50326667 0.16810000 -0.33516667 0.41202683 0.01511057 FALSE TRUE
ENST00000400060 ENSG00000173482 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPRM protein_coding protein_coding 2.423455 1.496829 3.229052 0.2705513 0.4566745 1.104056 0.27413597 0.27021822 0.27607767 0.13866847 0.27607767 0.02985618 0.13549167 0.17113333 0.11046667 -0.06066667 0.54545461 0.01511057 FALSE TRUE
ENST00000577827 ENSG00000173482 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPRM protein_coding retained_intron 2.423455 1.496829 3.229052 0.2705513 0.4566745 1.104056 0.23685162 0.15562386 0.24777965 0.04445747 0.03081296 0.63822784 0.10283750 0.10056667 0.08076667 -0.01980000 0.78566180 0.01511057 FALSE TRUE
ENST00000578916 ENSG00000173482 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPRM protein_coding protein_coding 2.423455 1.496829 3.229052 0.2705513 0.4566745 1.104056 0.26052745 0.01737018 0.59095684 0.01737018 0.23197919 4.45658465 0.08885833 0.01423333 0.16973333 0.15550000 0.01511057 0.01511057 FALSE FALSE
ENST00000580170 ENSG00000173482 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPRM protein_coding protein_coding 2.423455 1.496829 3.229052 0.2705513 0.4566745 1.104056 0.56291329 0.15844984 0.91546923 0.02739231 0.36770199 2.45786597 0.21881250 0.10810000 0.28610000 0.17800000 0.34348661 0.01511057 FALSE TRUE
ENST00000580949 ENSG00000173482 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPRM protein_coding processed_transcript 2.423455 1.496829 3.229052 0.2705513 0.4566745 1.104056 0.08734461 0.20918648 0.04251871 0.20918648 0.04251871 -2.06125533 0.03803750 0.10263333 0.01700000 -0.08563333 0.86472475 0.01511057   FALSE
ENST00000583153 ENSG00000173482 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPRM protein_coding protein_coding 2.423455 1.496829 3.229052 0.2705513 0.4566745 1.104056 0.09215594 0.00000000 0.24816801 0.00000000 0.19210587 4.69023833 0.03362500 0.00000000 0.06393333 0.06393333 0.37044424 0.01511057 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000173482 E001 0.4545463 0.7857009847 4.929299e-01 6.300268e-01 18 7566782 7567315 534 + 0.248 0.000 -13.083
ENSG00000173482 E002 9.1574669 0.0122898254 3.461892e-04 1.564814e-03 18 7567316 7567891 576 + 1.144 0.677 -1.786
ENSG00000173482 E003 0.0000000       18 7754973 7755284 312 +      
ENSG00000173482 E004 0.0000000       18 7774140 7774148 9 +      
ENSG00000173482 E005 7.2979531 0.0036493697 1.891915e-01 3.127226e-01 18 7774149 7774271 123 + 0.972 0.808 -0.626
ENSG00000173482 E006 12.8609594 0.0252687736 1.153154e-01 2.133101e-01 18 7888106 7888377 272 + 1.203 1.011 -0.693
ENSG00000173482 E007 6.1143237 0.0027002026 2.208043e-01 3.513975e-01 18 7906505 7906583 79 + 0.909 0.747 -0.631
ENSG00000173482 E008 7.3258488 0.0023214723 9.786738e-01 9.907651e-01 18 7926568 7926683 116 + 0.909 0.908 -0.002
ENSG00000173482 E009 1.2156818 0.0123771255 4.558709e-01 5.963621e-01 18 7946870 7946977 108 + 0.402 0.263 -0.869
ENSG00000173482 E010 12.8342111 0.0432160209 6.895114e-01 7.913841e-01 18 7949181 7949355 175 + 1.152 1.097 -0.197
ENSG00000173482 E011 17.8156137 0.0241758539 1.212122e-01 2.216618e-01 18 7955121 7955414 294 + 1.333 1.159 -0.613
ENSG00000173482 E012 0.0000000       18 8017792 8017822 31 +      
ENSG00000173482 E013 0.0000000       18 8017823 8018057 235 +      
ENSG00000173482 E014 0.0000000       18 8018058 8018095 38 +      
ENSG00000173482 E015 0.0000000       18 8049364 8049430 67 +      
ENSG00000173482 E016 22.5234941 0.0008614658 1.893650e-03 6.894328e-03 18 8069686 8069994 309 + 1.454 1.216 -0.829
ENSG00000173482 E017 12.9814079 0.0025593422 7.755593e-03 2.316480e-02 18 8076455 8076564 110 + 1.237 0.970 -0.962
ENSG00000173482 E018 8.7257921 0.0019889046 6.366234e-01 7.505999e-01 18 8085671 8085701 31 + 1.006 0.951 -0.206
ENSG00000173482 E019 17.2290229 0.0011028445 1.248861e-02 3.470732e-02 18 8085702 8085872 171 + 1.334 1.117 -0.765
ENSG00000173482 E020 14.0512717 0.0210159432 5.419080e-02 1.165842e-01 18 8088749 8088851 103 + 1.255 1.026 -0.820
ENSG00000173482 E021 9.6665854 0.0296626799 2.472036e-02 6.130323e-02 18 8113486 8113570 85 + 1.128 0.810 -1.185
ENSG00000173482 E022 13.2304482 0.0014182062 5.784646e-03 1.804607e-02 18 8113571 8113759 189 + 1.243 0.971 -0.984
ENSG00000173482 E023 6.4999593 0.0024738786 2.517535e-02 6.223683e-02 18 8114791 8114827 37 + 0.972 0.677 -1.158
ENSG00000173482 E024 0.0000000       18 8121852 8122241 390 +      
ENSG00000173482 E025 0.6643356 0.6353294315 1.641761e-01 2.806026e-01 18 8122242 8122316 75 + 0.000 0.374 14.345
ENSG00000173482 E026 13.4540768 0.0014880331 4.658745e-01 6.054760e-01 18 8143647 8143779 133 + 1.175 1.103 -0.256
ENSG00000173482 E027 0.0000000       18 8244057 8244057 1 +      
ENSG00000173482 E028 14.7447846 0.0014943619 6.340404e-01 7.486168e-01 18 8244058 8244209 152 + 1.204 1.157 -0.165
ENSG00000173482 E029 8.8863786 0.0020800797 6.423168e-01 7.551320e-01 18 8247845 8247873 29 + 1.006 0.951 -0.205
ENSG00000173482 E030 8.4381896 0.0021226104 5.861896e-01 7.097916e-01 18 8247874 8247919 46 + 0.995 0.930 -0.243
ENSG00000173482 E031 0.1451727 0.0431306835 7.729908e-01   18 8248150 8248176 27 + 0.098 0.000 -11.474
ENSG00000173482 E032 0.0000000       18 8251613 8251821 209 +      
ENSG00000173482 E033 0.1451727 0.0431306835 7.729908e-01   18 8252488 8252499 12 + 0.098 0.000 -11.474
ENSG00000173482 E034 16.3227568 0.0067361067 6.748059e-01 7.802541e-01 18 8253227 8253414 188 + 1.249 1.205 -0.155
ENSG00000173482 E035 0.1472490 0.0424771019 7.732312e-01   18 8270006 8270447 442 + 0.098 0.000 -11.474
ENSG00000173482 E036 15.3265326 0.0012224292 5.650198e-01 6.921963e-01 18 8296368 8296455 88 + 1.224 1.170 -0.192
ENSG00000173482 E037 14.1881544 0.0013524061 9.495503e-01 9.724069e-01 18 8314781 8314857 77 + 1.168 1.170 0.007
ENSG00000173482 E038 12.4766784 0.0026518828 7.103934e-01 8.075867e-01 18 8319178 8319214 37 + 1.128 1.089 -0.141
ENSG00000173482 E039 16.0526574 0.0011727630 8.750239e-01 9.237056e-01 18 8343423 8343520 98 + 1.217 1.227 0.034
ENSG00000173482 E040 9.9435186 0.0494017040 4.857474e-01 6.235704e-01 18 8370890 8370932 43 + 0.984 1.079 0.349
ENSG00000173482 E041 11.2624567 0.0251690609 8.528120e-01 9.087889e-01 18 8370933 8371006 74 + 1.076 1.089 0.048
ENSG00000173482 E042 1.0308569 0.0128201127 2.041808e-02 5.236918e-02 18 8371760 8371810 51 + 0.444 0.000 -14.282
ENSG00000173482 E043 15.3460522 0.0437682890 6.369214e-01 7.508671e-01 18 8376046 8376200 155 + 1.243 1.157 -0.305
ENSG00000173482 E044 13.9483309 0.0128372756 1.086595e-01 2.035580e-01 18 8376462 8376597 136 + 1.094 1.249 0.552
ENSG00000173482 E045 10.4994603 0.0018563606 7.099954e-01 8.072360e-01 18 8376598 8378264 1667 + 1.067 1.025 -0.152
ENSG00000173482 E046 18.9594968 0.0022874770 4.452283e-03 1.440748e-02 18 8378265 8378414 150 + 1.189 1.408 0.766
ENSG00000173482 E047 20.2113443 0.0009646674 1.175667e-03 4.559093e-03 18 8379167 8379340 174 + 1.204 1.442 0.834
ENSG00000173482 E048 21.8491937 0.0094938924 2.608244e-02 6.411200e-02 18 8380296 8380427 132 + 1.268 1.454 0.648
ENSG00000173482 E049 21.3703789 0.0255190548 2.127108e-01 3.417440e-01 18 8384561 8384686 126 + 1.285 1.419 0.464
ENSG00000173482 E050 23.2791492 0.0022128845 5.143562e-02 1.117059e-01 18 8387072 8387235 164 + 1.318 1.455 0.475
ENSG00000173482 E051 21.3614582 0.0013190433 6.996638e-05 3.798734e-04 18 8394476 8394611 136 + 1.197 1.486 1.008
ENSG00000173482 E052 0.1515154 0.0444155536 7.721500e-01   18 8399701 8399831 131 + 0.098 0.000 -11.475
ENSG00000173482 E053 41.6083387 0.0007000578 3.512122e-09 4.704525e-08 18 8406109 8406861 753 + 1.465 1.774 1.051