ENSG00000173320

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000308497 ENSG00000173320 HEK293_OSMI2_2hA HEK293_TMG_2hB STOX2 protein_coding protein_coding 1.665335 1.050404 2.236712 0.05441504 0.0640867 1.083202 0.3723672 0.24892081 0.4868967 0.05199226 0.017438458 0.940435 0.22179167 0.24246667 0.21846667 -0.0240000 1.00000000 0.02510325 FALSE TRUE
ENST00000506529 ENSG00000173320 HEK293_OSMI2_2hA HEK293_TMG_2hB STOX2 protein_coding protein_coding 1.665335 1.050404 2.236712 0.05441504 0.0640867 1.083202 0.3034931 0.35912636 0.1672065 0.19553955 0.167206546 -1.058683 0.23855000 0.35976667 0.07193333 -0.2878333 0.45720723 0.02510325 FALSE TRUE
ENST00000512520 ENSG00000173320 HEK293_OSMI2_2hA HEK293_TMG_2hB STOX2 protein_coding nonsense_mediated_decay 1.665335 1.050404 2.236712 0.05441504 0.0640867 1.083202 0.1655853 0.09623028 0.3004010 0.09623028 0.155694580 1.546938 0.07848333 0.08303333 0.13093333 0.0479000 0.78904142 0.02510325 FALSE TRUE
ENST00000513034 ENSG00000173320 HEK293_OSMI2_2hA HEK293_TMG_2hB STOX2 protein_coding protein_coding 1.665335 1.050404 2.236712 0.05441504 0.0640867 1.083202 0.1462399 0.27720860 0.1269048 0.22231394 0.002099149 -1.068926 0.11562917 0.24493333 0.05690000 -0.1880333 0.70195787 0.02510325 FALSE TRUE
MSTRG.25790.4 ENSG00000173320 HEK293_OSMI2_2hA HEK293_TMG_2hB STOX2 protein_coding   1.665335 1.050404 2.236712 0.05441504 0.0640867 1.083202 0.6708275 0.06891749 1.1553028 0.06891749 0.177503502 3.884216 0.34042083 0.06976667 0.52183333 0.4520667 0.02510325 0.02510325 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000173320 E001 1.3620004 0.009931433 1.363647e-01 2.429869e-01 4 183797692 183798055 364 + 0.436 0.174 -1.813
ENSG00000173320 E002 0.0000000       4 183853431 183853843 413 +      
ENSG00000173320 E003 15.0156744 0.001384142 3.667464e-01 5.110860e-01 4 183905307 183906834 1528 + 1.131 1.248 0.416
ENSG00000173320 E004 3.8407071 0.004064848 6.231100e-02 1.305346e-01 4 183906835 183906956 122 + 0.743 0.472 -1.207
ENSG00000173320 E005 0.2934659 0.030021577 5.954350e-01   4 183960259 183960290 32 + 0.085 0.173 1.181
ENSG00000173320 E006 6.5618764 0.003117529 9.367990e-02 1.808760e-01 4 184001325 184001477 153 + 0.921 0.734 -0.733
ENSG00000173320 E007 52.4049129 0.001220290 1.881862e-08 2.205326e-07 4 184009158 184010772 1615 + 1.781 1.523 -0.874
ENSG00000173320 E008 22.8725293 0.029440393 1.430341e-04 7.166533e-04 4 184010773 184011423 651 + 1.457 1.057 -1.407
ENSG00000173320 E009 1.6607648 0.008430649 6.716886e-02 1.386431e-01 4 184011587 184011635 49 + 0.499 0.173 -2.137
ENSG00000173320 E010 241.0376354 0.004138497 1.899767e-11 3.778950e-10 4 184017089 184023526 6438 + 2.306 2.450 0.480