ENSG00000173276

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000310826 ENSG00000173276 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB21 protein_coding protein_coding 6.196515 1.832762 10.87967 0.06789717 0.3564798 2.563019 1.2152298 0.60659186 2.1975754 0.30678951 0.6857523 1.8400749 0.2259792 0.33593333 0.20243333 -0.1335000 9.238108e-01 2.62406e-06 FALSE TRUE
ENST00000398497 ENSG00000173276 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB21 protein_coding protein_coding 6.196515 1.832762 10.87967 0.06789717 0.3564798 2.563019 0.3427996 0.03504694 0.9035310 0.03504694 0.3680819 4.3419528 0.0638000 0.01806667 0.08136667 0.0633000 2.739223e-01 2.62406e-06   FALSE
ENST00000398505 ENSG00000173276 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB21 protein_coding protein_coding 6.196515 1.832762 10.87967 0.06789717 0.3564798 2.563019 0.7028148 0.58447194 0.6360987 0.13329462 0.6360987 0.1201459 0.1531167 0.31870000 0.05983333 -0.2588667 8.799274e-02 2.62406e-06 FALSE TRUE
ENST00000398511 ENSG00000173276 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB21 protein_coding protein_coding 6.196515 1.832762 10.87967 0.06789717 0.3564798 2.563019 2.9098775 0.56188312 4.7770735 0.22289386 0.4325684 3.0653517 0.4249792 0.30173333 0.44140000 0.1396667 6.023007e-01 2.62406e-06 FALSE TRUE
MSTRG.21380.5 ENSG00000173276 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB21 protein_coding   6.196515 1.832762 10.87967 0.06789717 0.3564798 2.563019 0.7678510 0.00000000 2.0092390 0.00000000 0.4840548 7.6576679 0.0714125 0.00000000 0.18240000 0.1824000 2.624060e-06 2.62406e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000173276 E001 106.392322 0.0356722105 2.970595e-04 1.367906e-03 21 41986831 41988636 1806 - 1.833 2.214 1.277
ENSG00000173276 E002 326.876259 0.0023952658 8.380032e-04 3.394859e-03 21 41988637 41991334 2698 - 2.399 2.526 0.421
ENSG00000173276 E003 33.660574 0.0006689679 9.121637e-01 9.483201e-01 21 41991335 41991405 71 - 1.441 1.493 0.178
ENSG00000173276 E004 84.193658 0.0019536581 1.710498e-02 4.517555e-02 21 41991406 41991747 342 - 1.859 1.783 -0.257
ENSG00000173276 E005 33.579886 0.0111659069 8.451980e-01 9.036997e-01 21 41991748 41991889 142 - 1.449 1.475 0.089
ENSG00000173276 E006 71.611613 0.0014674457 7.239136e-02 1.473186e-01 21 41991890 41992492 603 - 1.786 1.735 -0.171
ENSG00000173276 E007 183.968176 0.0132252341 6.386331e-03 1.962707e-02 21 41992493 41993739 1247 - 2.203 2.094 -0.366
ENSG00000173276 E008 41.754807 0.0006978501 4.101022e-04 1.813003e-03 21 41993740 41993947 208 - 1.583 1.373 -0.724
ENSG00000173276 E009 35.889128 0.0006910904 5.330151e-09 6.920100e-08 21 41993948 41994108 161 - 1.550 1.077 -1.657
ENSG00000173276 E010 3.482369 0.2039737165 1.202439e-01 2.203358e-01 21 42002350 42002503 154 - 0.644 0.230 -2.290
ENSG00000173276 E011 3.031157 0.1918418098 7.128242e-01 8.094244e-01 21 42002504 42002563 60 - 0.541 0.495 -0.219
ENSG00000173276 E012 6.220763 0.0227866673 9.926391e-01 9.994821e-01 21 42002897 42002961 65 - 0.775 0.812 0.149
ENSG00000173276 E013 1.063236 0.0116611632 6.994009e-01 7.991695e-01 21 42007820 42008057 238 - 0.285 0.226 -0.441
ENSG00000173276 E014 2.290556 0.0175155300 1.861460e-01 3.089122e-01 21 42009467 42009597 131 - 0.379 0.646 1.298
ENSG00000173276 E015 21.832353 0.0057597488 2.838589e-03 9.789777e-03 21 42010252 42010387 136 - 1.325 1.051 -0.973