ENSG00000173153

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000000442 ENSG00000173153 HEK293_OSMI2_2hA HEK293_TMG_2hB ESRRA protein_coding protein_coding 33.56075 62.1884 19.60982 3.407152 0.3412781 -1.664565 14.213249 19.567075 10.973445 3.4162437 0.06261797 -0.8338346 0.42530417 0.31173333 0.5600333 0.24830000 0.0015829696 1.24721e-05 FALSE TRUE
ENST00000405666 ENSG00000173153 HEK293_OSMI2_2hA HEK293_TMG_2hB ESRRA protein_coding protein_coding 33.56075 62.1884 19.60982 3.407152 0.3412781 -1.664565 4.825577 8.940302 2.735003 4.5964356 0.74844004 -1.7051285 0.14834167 0.14666667 0.1404667 -0.00620000 0.9328957760 1.24721e-05 FALSE TRUE
MSTRG.5673.7 ENSG00000173153 HEK293_OSMI2_2hA HEK293_TMG_2hB ESRRA protein_coding   33.56075 62.1884 19.60982 3.407152 0.3412781 -1.664565 1.655565 8.097126 0.000000 4.8241203 0.00000000 -9.6630468 0.03430000 0.12696667 0.0000000 -0.12696667 0.2653675856 1.24721e-05 FALSE TRUE
MSTRG.5673.8 ENSG00000173153 HEK293_OSMI2_2hA HEK293_TMG_2hB ESRRA protein_coding   33.56075 62.1884 19.60982 3.407152 0.3412781 -1.664565 6.886652 16.755155 1.482726 2.9822068 0.42097856 -3.4894441 0.20297083 0.27286667 0.0749000 -0.19796667 0.0081807029 1.24721e-05 FALSE TRUE
MSTRG.5673.9 ENSG00000173153 HEK293_OSMI2_2hA HEK293_TMG_2hB ESRRA protein_coding   33.56075 62.1884 19.60982 3.407152 0.3412781 -1.664565 2.941124 3.582500 2.289581 0.3114935 0.05653818 -0.6436168 0.09482917 0.05756667 0.1169000 0.05933333 0.0000124721 1.24721e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000173153 E001 0.8010032 0.1355661146 1.087681e-01 2.037192e-01 11 64305497 64305523 27 + 0.441 0.134 -2.278
ENSG00000173153 E002 3.2378928 0.0224129831 1.408135e-06 1.131999e-05 11 64305524 64305538 15 + 1.017 0.279 -3.380
ENSG00000173153 E003 9.7546927 0.0019106906 1.933310e-23 1.800687e-21 11 64305539 64305579 41 + 1.507 0.475 -3.971
ENSG00000173153 E004 15.9497734 0.0012734487 7.077661e-37 1.995300e-34 11 64305580 64305608 29 + 1.712 0.628 -3.959
ENSG00000173153 E005 73.1637528 0.0173761762 8.767528e-07 7.368714e-06 11 64305609 64305736 128 + 2.028 1.675 -1.191
ENSG00000173153 E006 9.6726359 0.0086150755 4.921922e-03 1.571251e-02 11 64305901 64305930 30 + 1.161 0.844 -1.173
ENSG00000173153 E007 10.3240255 0.0030081001 3.043332e-03 1.039316e-02 11 64306152 64306186 35 + 1.195 0.885 -1.136
ENSG00000173153 E008 14.7922812 0.0107595544 5.251962e-04 2.253864e-03 11 64306187 64306225 39 + 1.356 1.017 -1.210
ENSG00000173153 E009 11.6652973 0.0214863978 3.369500e-03 1.134951e-02 11 64306226 64306226 1 + 1.256 0.917 -1.228
ENSG00000173153 E010 21.7705719 0.0035539727 1.190674e-05 7.774775e-05 11 64306227 64306285 59 + 1.515 1.173 -1.191
ENSG00000173153 E011 18.6028139 0.0019552310 2.978137e-04 1.370713e-03 11 64306286 64306295 10 + 1.419 1.123 -1.041
ENSG00000173153 E012 70.4951619 0.0003470362 3.961900e-03 1.303684e-02 11 64306296 64306445 150 + 1.854 1.728 -0.424
ENSG00000173153 E013 35.6025352 0.0005804986 1.658596e-01 2.828085e-01 11 64306446 64306448 3 + 1.530 1.448 -0.280
ENSG00000173153 E014 13.5799702 0.0039889163 1.151801e-03 4.477289e-03 11 64306449 64306846 398 + 1.296 0.986 -1.115
ENSG00000173153 E015 519.2300673 0.0002708715 4.339822e-05 2.481412e-04 11 64307168 64307504 337 + 2.666 2.603 -0.207
ENSG00000173153 E016 23.9050108 0.0145403437 6.514895e-01 7.623534e-01 11 64313771 64313950 180 + 1.321 1.292 -0.102
ENSG00000173153 E017 389.2789243 0.0017657250 8.756901e-01 9.241496e-01 11 64313951 64314067 117 + 2.479 2.498 0.065
ENSG00000173153 E018 211.1567725 0.0002133321 2.275603e-02 5.724345e-02 11 64314239 64314283 45 + 2.161 2.243 0.274
ENSG00000173153 E019 310.5178713 0.0001550053 6.289366e-02 1.315341e-01 11 64314284 64314367 84 + 2.347 2.405 0.195
ENSG00000173153 E020 151.7665996 0.0002540508 8.216130e-01 8.874831e-01 11 64314741 64314743 3 + 2.069 2.089 0.068
ENSG00000173153 E021 428.1531868 0.0001806632 3.395600e-01 4.834957e-01 11 64314744 64314911 168 + 2.508 2.541 0.109
ENSG00000173153 E022 498.9089950 0.0002266043 1.861987e-01 3.089700e-01 11 64315001 64315270 270 + 2.571 2.609 0.128
ENSG00000173153 E023 1257.9636538 0.0016401224 5.092549e-10 7.958821e-09 11 64315707 64316743 1037 + 2.898 3.028 0.432