ENSG00000173120

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000524657 ENSG00000173120 HEK293_OSMI2_2hA HEK293_TMG_2hB KDM2A protein_coding processed_transcript 26.87608 31.32936 21.79753 1.343542 0.6729357 -0.5231499 4.6489092 9.1657357 1.381338 1.2642618 0.1545248 -2.7213513 0.16290417 0.29710000 0.06306667 -0.23403333 1.756049e-06 6.157639e-13 FALSE TRUE
ENST00000529006 ENSG00000173120 HEK293_OSMI2_2hA HEK293_TMG_2hB KDM2A protein_coding protein_coding 26.87608 31.32936 21.79753 1.343542 0.6729357 -0.5231499 3.4901251 2.5729871 5.154245 0.3345948 0.3361013 0.9995169 0.13792500 0.08173333 0.23660000 0.15486667 4.264152e-09 6.157639e-13 FALSE TRUE
ENST00000530342 ENSG00000173120 HEK293_OSMI2_2hA HEK293_TMG_2hB KDM2A protein_coding protein_coding 26.87608 31.32936 21.79753 1.343542 0.6729357 -0.5231499 5.3794249 6.9653584 4.199468 1.2709039 0.1055359 -0.7286294 0.19901250 0.21980000 0.19276667 -0.02703333 7.945997e-01 6.157639e-13 FALSE TRUE
ENST00000531696 ENSG00000173120 HEK293_OSMI2_2hA HEK293_TMG_2hB KDM2A protein_coding processed_transcript 26.87608 31.32936 21.79753 1.343542 0.6729357 -0.5231499 1.9570125 3.5988292 0.000000 0.7606792 0.0000000 -8.4953871 0.06132083 0.11726667 0.00000000 -0.11726667 6.157639e-13 6.157639e-13 FALSE TRUE
MSTRG.5793.1 ENSG00000173120 HEK293_OSMI2_2hA HEK293_TMG_2hB KDM2A protein_coding   26.87608 31.32936 21.79753 1.343542 0.6729357 -0.5231499 0.7811605 0.4439167 1.790242 0.4439167 1.3002638 1.9876914 0.03167917 0.01323333 0.08443333 0.07120000 5.181325e-01 6.157639e-13 FALSE TRUE
MSTRG.5793.2 ENSG00000173120 HEK293_OSMI2_2hA HEK293_TMG_2hB KDM2A protein_coding   26.87608 31.32936 21.79753 1.343542 0.6729357 -0.5231499 7.2495740 5.5278764 6.445911 1.2612773 1.0765616 0.2212878 0.27992083 0.17373333 0.29380000 0.12006667 2.104445e-01 6.157639e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000173120 E001 3.6765128 0.0787387613 7.895521e-01 8.653196e-01 11 67119097 67119114 18 + 0.625 0.674 0.209
ENSG00000173120 E002 3.5249973 0.1025841092 9.347004e-01 9.628729e-01 11 67119115 67119122 8 + 0.590 0.676 0.370
ENSG00000173120 E003 3.6722464 0.1177919697 7.986130e-01 8.715040e-01 11 67119123 67119156 34 + 0.625 0.677 0.224
ENSG00000173120 E004 3.7309176 0.0043563959 1.222088e-01 2.230957e-01 11 67119263 67119268 6 + 0.741 0.598 -0.605
ENSG00000173120 E005 38.9096024 0.0006044878 6.775425e-10 1.037407e-08 11 67119269 67119690 422 + 1.709 1.462 -0.843
ENSG00000173120 E006 35.6562718 0.0022232574 1.482973e-08 1.770846e-07 11 67119691 67119869 179 + 1.675 1.427 -0.849
ENSG00000173120 E007 35.7980373 0.0007831940 7.549871e-05 4.066473e-04 11 67119870 67119890 21 + 1.625 1.495 -0.443
ENSG00000173120 E008 62.1694883 0.0049379429 2.198700e-04 1.049027e-03 11 67119891 67119975 85 + 1.846 1.748 -0.333
ENSG00000173120 E009 69.2872184 0.0004751492 2.852559e-07 2.652313e-06 11 67119976 67120049 74 + 1.899 1.783 -0.391
ENSG00000173120 E010 56.3847699 0.0033781517 2.628351e-04 1.228161e-03 11 67121234 67121268 35 + 1.798 1.705 -0.315
ENSG00000173120 E011 88.9348040 0.0051477274 1.588625e-03 5.922081e-03 11 67121269 67121358 90 + 1.976 1.923 -0.179
ENSG00000173120 E012 10.6579069 0.0020927765 2.758205e-02 6.717695e-02 11 67131952 67132073 122 + 1.122 0.995 -0.460
ENSG00000173120 E013 0.6934063 0.0951716414 7.520438e-02 1.518588e-01 11 67143204 67143371 168 + 0.000 0.364 33.408
ENSG00000173120 E014 2.3279277 0.1785109422 2.141477e-02 5.446174e-02 11 67149055 67149207 153 + 0.121 0.712 3.691
ENSG00000173120 E015 100.3355545 0.0078657054 2.044692e-05 1.265550e-04 11 67180079 67180217 139 + 2.064 1.938 -0.421
ENSG00000173120 E016 0.1817044 0.0393501415 5.919314e-01   11 67180218 67180453 236 + 0.000 0.124 31.536
ENSG00000173120 E017 80.0499588 0.0034807291 3.707349e-07 3.365823e-06 11 67181320 67181398 79 + 1.973 1.834 -0.469
ENSG00000173120 E018 71.8549338 0.0079687608 5.384793e-05 3.009774e-04 11 67181846 67181892 47 + 1.923 1.790 -0.446
ENSG00000173120 E019 87.3898402 0.0003213528 9.892543e-11 1.746447e-09 11 67207510 67207567 58 + 2.012 1.870 -0.476
ENSG00000173120 E020 87.2869347 0.0003981714 2.866534e-14 8.808700e-13 11 67207568 67207601 34 + 2.032 1.844 -0.630
ENSG00000173120 E021 111.4191425 0.0003745294 6.970384e-14 2.024093e-12 11 67207602 67207688 87 + 2.120 1.969 -0.506
ENSG00000173120 E022 115.3919755 0.0013695539 3.184452e-07 2.930252e-06 11 67215340 67215446 107 + 2.104 2.021 -0.279
ENSG00000173120 E023 0.1451727 0.0437242668 3.988414e-01   11 67215447 67215673 227 + 0.121 0.000 -31.860
ENSG00000173120 E024 83.8504198 0.0003501170 1.872118e-06 1.465870e-05 11 67215856 67215910 55 + 1.967 1.887 -0.270
ENSG00000173120 E025 59.4638094 0.0004150723 1.375580e-06 1.108604e-05 11 67215911 67215949 39 + 1.840 1.724 -0.392
ENSG00000173120 E026 0.4772466 0.0206900830 7.013254e-01 8.005350e-01 11 67217543 67217730 188 + 0.121 0.219 1.031
ENSG00000173120 E027 60.4975713 0.0011119215 2.768910e-06 2.088722e-05 11 67217731 67217755 25 + 1.848 1.732 -0.392
ENSG00000173120 E028 127.8030549 0.0003419107 7.980588e-08 8.261740e-07 11 67217756 67217884 129 + 2.141 2.075 -0.222
ENSG00000173120 E029 108.8740764 0.0002649858 1.368097e-06 1.103277e-05 11 67219288 67219403 116 + 2.068 2.007 -0.202
ENSG00000173120 E030 0.4407149 0.0217048062 4.471775e-01 5.886028e-01 11 67219404 67219688 285 + 0.216 0.123 -0.969
ENSG00000173120 E031 108.4072164 0.0002556307 4.710617e-05 2.671253e-04 11 67228037 67228163 127 + 2.053 2.019 -0.116
ENSG00000173120 E032 147.1705354 0.0003449774 6.353685e-03 1.954195e-02 11 67231566 67231764 199 + 2.152 2.175 0.076
ENSG00000173120 E033 135.2804949 0.0003361897 2.367912e-02 5.915004e-02 11 67231765 67231960 196 + 2.111 2.145 0.114
ENSG00000173120 E034 36.6494919 0.0009537111 5.743011e-01 7.001416e-01 11 67240047 67240300 254 + 1.537 1.607 0.238
ENSG00000173120 E035 33.5374460 0.0005837905 3.219372e-01 4.652000e-01 11 67240301 67240369 69 + 1.512 1.555 0.146
ENSG00000173120 E036 122.5827332 0.0006241614 8.946964e-03 2.614735e-02 11 67243009 67243092 84 + 2.078 2.095 0.057
ENSG00000173120 E037 0.4481018 0.1867061919 7.486079e-01 8.357876e-01 11 67243507 67243816 310 + 0.121 0.216 1.002
ENSG00000173120 E038 0.2903454 0.3934237913 2.337042e-01   11 67245078 67245188 111 + 0.215 0.000 -32.501
ENSG00000173120 E039 247.4676303 0.0022783210 8.039645e-03 2.387807e-02 11 67245189 67245458 270 + 2.377 2.402 0.082
ENSG00000173120 E040 6.0209311 0.0917574943 5.026504e-01 6.386908e-01 11 67245539 67245984 446 + 0.852 0.841 -0.041
ENSG00000173120 E041 166.7334795 0.0002511519 2.534455e-04 1.189567e-03 11 67245985 67246116 132 + 2.220 2.223 0.010
ENSG00000173120 E042 139.2185143 0.0002386726 6.160158e-05 3.393299e-04 11 67248281 67248370 90 + 2.152 2.136 -0.056
ENSG00000173120 E043 1.1919347 0.2408314028 2.646009e-01 4.025654e-01 11 67248371 67248379 9 + 0.417 0.225 -1.250
ENSG00000173120 E044 1.8700171 0.1430043771 3.338093e-02 7.854043e-02 11 67248545 67248605 61 + 0.627 0.220 -2.294
ENSG00000173120 E045 195.3235914 0.0010620778 4.383794e-02 9.809091e-02 11 67250086 67250346 261 + 2.261 2.307 0.154
ENSG00000173120 E046 299.5132185 0.0002619775 3.289923e-01 4.724791e-01 11 67250347 67250798 452 + 2.399 2.525 0.421
ENSG00000173120 E047 13.1715662 0.0047234453 3.011518e-01 4.429286e-01 11 67252338 67252693 356 + 1.152 1.151 -0.004
ENSG00000173120 E048 226.4933654 0.0026247563 2.502730e-01 3.862541e-01 11 67252694 67252857 164 + 2.267 2.413 0.488
ENSG00000173120 E049 216.6191582 0.0017967632 6.548892e-01 7.649331e-01 11 67253453 67253611 159 + 2.279 2.373 0.312
ENSG00000173120 E050 301.3898723 0.0024118058 4.024648e-01 5.462082e-01 11 67254203 67254418 216 + 2.398 2.533 0.451
ENSG00000173120 E051 2526.6044357 0.0066753733 1.762946e-12 4.148880e-11 11 67254874 67258082 3209 + 3.219 3.512 0.974