ENSG00000173113

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000308774 ENSG00000173113 HEK293_OSMI2_2hA HEK293_TMG_2hB TRMT112 protein_coding protein_coding 526.3474 1001.663 251.508 50.25604 4.816858 -1.993678 70.90658 121.3236 37.96811 11.697255 2.6711553 -1.675739 0.1343958 0.1213667 0.1511333 0.02976667 0.415083954 0.000174605 FALSE TRUE
ENST00000539854 ENSG00000173113 HEK293_OSMI2_2hA HEK293_TMG_2hB TRMT112 protein_coding retained_intron 526.3474 1001.663 251.508 50.25604 4.816858 -1.993678 59.81364 113.1610 31.49868 2.830169 2.5952430 -1.844683 0.1121167 0.1132667 0.1253000 0.01203333 0.723365722 0.000174605 FALSE FALSE
ENST00000544844 ENSG00000173113 HEK293_OSMI2_2hA HEK293_TMG_2hB TRMT112 protein_coding protein_coding 526.3474 1001.663 251.508 50.25604 4.816858 -1.993678 151.25573 352.7544 55.84968 14.713493 4.2858490 -2.658826 0.2659333 0.3533667 0.2215667 -0.13180000 0.000174605 0.000174605 FALSE TRUE
MSTRG.5674.11 ENSG00000173113 HEK293_OSMI2_2hA HEK293_TMG_2hB TRMT112 protein_coding   526.3474 1001.663 251.508 50.25604 4.816858 -1.993678 199.61583 337.5700 101.47517 31.702777 0.7775163 -1.733960 0.3984417 0.3354667 0.4037333 0.06826667 0.055717017 0.000174605 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000173113 E001 11.2316552 1.572242e-03 1.207679e-01 2.210528e-01 11 64316460 64316690 231 - 0.736 0.962 0.876
ENSG00000173113 E002 43.0618627 1.083046e-03 4.094089e-14 1.229570e-12 11 64316691 64316693 3 - 0.598 1.546 3.528
ENSG00000173113 E003 43.5798943 1.009751e-03 2.415317e-14 7.504913e-13 11 64316694 64316694 1 - 0.598 1.551 3.546
ENSG00000173113 E004 43.7615987 1.123984e-03 2.273829e-14 7.095538e-13 11 64316695 64316695 1 - 0.598 1.553 3.552
ENSG00000173113 E005 3440.9088560 2.547958e-04 3.464111e-02 8.097244e-02 11 64316696 64316855 160 - 3.357 3.377 0.067
ENSG00000173113 E006 2601.6533674 6.974223e-04 8.306577e-04 3.368583e-03 11 64316856 64316866 11 - 3.210 3.260 0.166
ENSG00000173113 E007 5113.5190126 2.494099e-04 1.251295e-03 4.814161e-03 11 64316867 64316968 102 - 3.523 3.550 0.092
ENSG00000173113 E008 337.3214437 1.534051e-04 6.637962e-02 1.373597e-01 11 64316969 64317057 89 - 2.325 2.372 0.157
ENSG00000173113 E009 5764.8067378 2.866835e-05 7.892195e-04 3.220715e-03 11 64317058 64317132 75 - 3.582 3.599 0.058
ENSG00000173113 E010 4041.9361262 1.139387e-04 1.704995e-01 2.888059e-01 11 64317133 64317147 15 - 3.456 3.441 -0.049
ENSG00000173113 E011 30.3760592 1.006273e-03 2.441244e-01 3.790499e-01 11 64317148 64317263 116 - 1.418 1.317 -0.349
ENSG00000173113 E012 6424.7698688 2.043800e-04 2.867552e-07 2.665207e-06 11 64317264 64317365 102 - 3.681 3.639 -0.140
ENSG00000173113 E013 279.8617949 1.151428e-03 8.509860e-03 2.506245e-02 11 64317366 64317448 83 - 2.358 2.270 -0.296
ENSG00000173113 E014 4462.8366367 5.065364e-04 1.354195e-03 5.157059e-03 11 64317449 64317672 224 - 3.521 3.481 -0.131
ENSG00000173113 E015 74.7222405 3.439613e-04 1.463191e-02 3.966619e-02 11 64317673 64317740 68 - 1.830 1.697 -0.450
ENSG00000173113 E016 70.6866531 8.191439e-04 6.203108e-04 2.607758e-03 11 64317741 64317807 67 - 1.849 1.660 -0.639
ENSG00000173113 E017 48.3848587 5.869273e-04 8.710493e-05 4.614588e-04 11 64317959 64318025 67 - 1.735 1.488 -0.841
ENSG00000173113 E018 0.6537541 4.772413e-01 2.393700e-01 3.733938e-01 11 64318542 64318832 291 - 0.393 0.110 -2.352