ENSG00000173083

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000311412 ENSG00000173083 HEK293_OSMI2_2hA HEK293_TMG_2hB HPSE protein_coding protein_coding 1.285018 1.422952 1.214279 0.08204915 0.1912055 -0.2270584 0.38728738 0.37552470 0.3024656 0.02356139 0.1520271 -0.30312586 0.34667083 0.26623333 0.2254333 -0.04080000 0.85394746 0.03413049 FALSE TRUE
ENST00000405413 ENSG00000173083 HEK293_OSMI2_2hA HEK293_TMG_2hB HPSE protein_coding protein_coding 1.285018 1.422952 1.214279 0.08204915 0.1912055 -0.2270584 0.02319218 0.00000000 0.1251166 0.00000000 0.1251166 3.75613328 0.02506250 0.00000000 0.1402333 0.14023333 0.82679180 0.03413049 FALSE TRUE
ENST00000507150 ENSG00000173083 HEK293_OSMI2_2hA HEK293_TMG_2hB HPSE protein_coding nonsense_mediated_decay 1.285018 1.422952 1.214279 0.08204915 0.1912055 -0.2270584 0.02516094 0.09843906 0.0000000 0.09843906 0.0000000 -3.43881267 0.01970417 0.06906667 0.0000000 -0.06906667 0.78853259 0.03413049 TRUE TRUE
ENST00000509906 ENSG00000173083 HEK293_OSMI2_2hA HEK293_TMG_2hB HPSE protein_coding nonsense_mediated_decay 1.285018 1.422952 1.214279 0.08204915 0.1912055 -0.2270584 0.05788602 0.08507625 0.1863481 0.08507625 0.1863481 1.04625635 0.03716667 0.05970000 0.1557333 0.09603333 1.00000000 0.03413049 TRUE TRUE
ENST00000512196 ENSG00000173083 HEK293_OSMI2_2hA HEK293_TMG_2hB HPSE protein_coding protein_coding 1.285018 1.422952 1.214279 0.08204915 0.1912055 -0.2270584 0.15221788 0.18917658 0.0000000 0.18917658 0.0000000 -4.31597611 0.10715417 0.12096667 0.0000000 -0.12096667 0.77665262 0.03413049 FALSE TRUE
ENST00000513463 ENSG00000173083 HEK293_OSMI2_2hA HEK293_TMG_2hB HPSE protein_coding protein_coding 1.285018 1.422952 1.214279 0.08204915 0.1912055 -0.2270584 0.21475828 0.00000000 0.2331643 0.00000000 0.2331643 4.60385959 0.13815000 0.00000000 0.1500333 0.15003333 0.77816849 0.03413049 FALSE TRUE
ENST00000680713 ENSG00000173083 HEK293_OSMI2_2hA HEK293_TMG_2hB HPSE protein_coding retained_intron 1.285018 1.422952 1.214279 0.08204915 0.1912055 -0.2270584 0.11191124 0.29039890 0.0000000 0.15231228 0.0000000 -4.90880763 0.09090000 0.21790000 0.0000000 -0.21790000 0.03413049 0.03413049 FALSE TRUE
ENST00000681769 ENSG00000173083 HEK293_OSMI2_2hA HEK293_TMG_2hB HPSE protein_coding protein_coding 1.285018 1.422952 1.214279 0.08204915 0.1912055 -0.2270584 0.31260405 0.38433680 0.3671843 0.08412398 0.1082115 -0.06415884 0.23520000 0.26610000 0.3285667 0.06246667 0.90275766 0.03413049 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000173083 E001 0.1817044 0.040822798 0.559446994   4 83292461 83292523 63 - 0.000 0.115 9.300
ENSG00000173083 E002 20.6015046 0.005666703 0.643061703 0.75569353 4 83292524 83293595 1072 - 1.306 1.351 0.157
ENSG00000173083 E003 16.5352622 0.001395545 0.174092632 0.29349474 4 83293596 83295319 1724 - 1.291 1.191 -0.351
ENSG00000173083 E004 1.8174865 0.013350823 0.533027242 0.66527270 4 83295320 83295343 24 - 0.380 0.494 0.597
ENSG00000173083 E005 5.7309652 0.069389633 0.808827890 0.87860241 4 83295344 83295503 160 - 0.842 0.836 -0.022
ENSG00000173083 E006 11.2159667 0.001878968 0.831402464 0.89431803 4 83300960 83301106 147 - 1.098 1.086 -0.044
ENSG00000173083 E007 10.5266364 0.002057759 0.753414706 0.83936392 4 83302150 83302268 119 - 1.047 1.086 0.141
ENSG00000173083 E008 10.5559822 0.001860593 0.830812960 0.89389374 4 83306203 83306317 115 - 1.047 1.075 0.103
ENSG00000173083 E009 7.9545461 0.002325993 0.666407307 0.77383978 4 83308845 83308951 107 - 0.973 0.933 -0.150
ENSG00000173083 E010 8.3157663 0.002282138 0.551154965 0.68066960 4 83309402 83309495 94 - 1.004 0.948 -0.209
ENSG00000173083 E011 5.4133626 0.003061767 0.243700737 0.37853168 4 83310031 83310078 48 - 0.883 0.743 -0.550
ENSG00000173083 E012 10.1092161 0.002229518 0.633020665 0.74780421 4 83310722 83310890 169 - 1.019 1.075 0.205
ENSG00000173083 E013 11.2446722 0.002154760 0.936500580 0.96407210 4 83313114 83313287 174 - 1.086 1.086 0.000
ENSG00000173083 E014 1.9823367 0.180203953 0.004404385 0.01427653 4 83318930 83319343 414 - 0.000 0.618 12.681
ENSG00000173083 E015 13.7880686 0.001489699 0.846580616 0.90465724 4 83319344 83319469 126 - 1.166 1.156 -0.034
ENSG00000173083 E016 14.3103560 0.001516763 0.504263563 0.64015667 4 83322219 83322364 146 - 1.205 1.156 -0.175
ENSG00000173083 E017 14.7329070 0.001332389 0.285224093 0.42553360 4 83334556 83334813 258 - 1.133 1.232 0.349
ENSG00000173083 E018 3.5762912 0.004819601 0.468199303 0.60763112 4 83334814 83334848 35 - 0.580 0.694 0.493
ENSG00000173083 E019 0.4470576 0.023618618 0.474573922 0.61339214 4 83335048 83335153 106 - 0.230 0.115 -1.211