ENSG00000173041

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000309683 ENSG00000173041 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF680 protein_coding protein_coding 4.035099 0.9761255 7.027415 0.1044227 0.26547 2.835202 2.5791473 0.75904407 4.3492151 0.02769390 0.2841464 2.502930 0.68570833 0.79160000 0.61830000 -0.173300000 0.145142478 0.005729276 FALSE TRUE
ENST00000473601 ENSG00000173041 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF680 protein_coding processed_transcript 4.035099 0.9761255 7.027415 0.1044227 0.26547 2.835202 0.2290267 0.07192556 0.4761287 0.07192556 0.2024256 2.568953 0.06547500 0.06250000 0.06586667 0.003366667 0.859367104 0.005729276   FALSE
ENST00000476563 ENSG00000173041 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF680 protein_coding processed_transcript 4.035099 0.9761255 7.027415 0.1044227 0.26547 2.835202 0.2755566 0.00000000 0.4271950 0.00000000 0.2192507 5.450205 0.04365417 0.00000000 0.06160000 0.061600000 0.568483617 0.005729276 FALSE FALSE
MSTRG.29904.2 ENSG00000173041 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF680 protein_coding   4.035099 0.9761255 7.027415 0.1044227 0.26547 2.835202 0.8766634 0.06672926 1.6564835 0.02036198 0.1073911 4.440886 0.17754583 0.06616667 0.23713333 0.170966667 0.005729276 0.005729276 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000173041 E001 69.5942822 0.0004340602 7.574312e-16 2.908250e-14 7 64519878 64521042 1165 - 1.639 1.987 1.173
ENSG00000173041 E002 35.5691990 0.0007066557 9.118607e-01 9.480855e-01 7 64521043 64521261 219 - 1.428 1.423 -0.019
ENSG00000173041 E003 28.4197985 0.0008986509 8.976364e-01 9.386565e-01 7 64521262 64521429 168 - 1.335 1.349 0.048
ENSG00000173041 E004 53.6172646 0.0004787142 4.435701e-04 1.942017e-03 7 64521430 64521925 496 - 1.637 1.394 -0.830
ENSG00000173041 E005 48.3212475 0.0005183220 1.371510e-02 3.757353e-02 7 64521926 64522449 524 - 1.582 1.409 -0.593
ENSG00000173041 E006 15.1788018 0.0040090678 1.540824e-01 2.672152e-01 7 64522450 64522500 51 - 1.105 0.924 -0.668
ENSG00000173041 E007 4.4466765 0.0191338689 1.377382e-03 5.232738e-03 7 64524699 64526517 1819 - 0.504 1.001 2.038
ENSG00000173041 E008 12.6931711 0.0128246219 2.754453e-01 4.147508e-01 7 64543707 64543802 96 - 1.033 0.879 -0.576
ENSG00000173041 E009 0.1482932 0.0414686213 5.661673e-02   7 64543803 64544219 417 - 0.000 0.260 11.788
ENSG00000173041 E010 7.4223827 0.0023320597 2.123268e-02 5.407850e-02 7 64544306 64544345 40 - 0.857 0.422 -1.915
ENSG00000173041 E011 12.3375306 0.0015167634 7.275087e-03 2.193956e-02 7 64544346 64544432 87 - 1.049 0.632 -1.635
ENSG00000173041 E012 2.5246766 0.0855777110 5.872956e-01 7.106055e-01 7 64560946 64561273 328 - 0.428 0.542 0.562
ENSG00000173041 E013 19.8354527 0.0056552042 1.736928e-03 6.398877e-03 7 64562925 64563075 151 - 1.237 0.829 -1.501