ENSG00000173039

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000406246 ENSG00000173039 HEK293_OSMI2_2hA HEK293_TMG_2hB RELA protein_coding protein_coding 60.31926 92.8423 40.16593 5.40755 1.624802 -1.208606 50.61833 85.36758 32.16947 4.736606 0.8543095 -1.407717 0.8110667 0.9198333 0.8019 -0.1179333 8.095842e-09 8.095842e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000173039 E001 0.4772466 0.0207906258 8.143120e-01 8.823450e-01 11 65653599 65653600 2 - 0.181 0.149 -0.336
ENSG00000173039 E002 3.3567188 0.0130740049 4.597089e-01 5.998256e-01 11 65653601 65653601 1 - 0.487 0.631 0.663
ENSG00000173039 E003 1150.9623900 0.0053791811 2.325486e-08 2.677015e-07 11 65653602 65653966 365 - 2.815 3.044 0.759
ENSG00000173039 E004 1655.3250326 0.0011268406 6.691369e-14 1.948148e-12 11 65653967 65654509 543 - 3.030 3.188 0.526
ENSG00000173039 E005 624.2703306 0.0010271112 6.675718e-03 2.038055e-02 11 65654510 65654682 173 - 2.664 2.748 0.279
ENSG00000173039 E006 495.7255655 0.0002069719 1.197295e-07 1.198688e-06 11 65654683 65654811 129 - 2.530 2.656 0.420
ENSG00000173039 E007 233.6077812 0.0010219593 3.767958e-03 1.249043e-02 11 65654812 65654818 7 - 2.217 2.329 0.376
ENSG00000173039 E008 599.9352299 0.0001306841 1.515298e-04 7.538569e-04 11 65654819 65655000 182 - 2.644 2.731 0.289
ENSG00000173039 E009 29.8662510 0.0065555719 5.982067e-02 1.263079e-01 11 65655001 65655687 687 - 1.519 1.394 -0.430
ENSG00000173039 E010 279.5002817 0.0009251243 9.338213e-01 9.622813e-01 11 65655688 65655706 19 - 2.365 2.389 0.080
ENSG00000173039 E011 345.5532700 0.0001502491 8.821413e-01 9.285215e-01 11 65655707 65655762 56 - 2.455 2.479 0.080
ENSG00000173039 E012 207.3145329 0.0001798809 2.823082e-01 4.222854e-01 11 65655855 65655856 2 - 2.213 2.264 0.172
ENSG00000173039 E013 434.9334182 0.0001559297 4.232962e-01 5.663669e-01 11 65655857 65655935 79 - 2.567 2.572 0.017
ENSG00000173039 E014 334.7409984 0.0004610815 1.285147e-02 3.556811e-02 11 65658287 65658317 31 - 2.485 2.447 -0.125
ENSG00000173039 E015 496.5631664 0.0017146843 4.822224e-02 1.060289e-01 11 65658318 65658429 112 - 2.650 2.622 -0.093
ENSG00000173039 E016 445.8642322 0.0003548915 2.915420e-04 1.345377e-03 11 65658430 65658499 70 - 2.620 2.568 -0.174
ENSG00000173039 E017 8.6587164 0.0019448099 8.828618e-08 9.055033e-07 11 65658602 65658717 116 - 1.269 0.708 -2.098
ENSG00000173039 E018 303.1639144 0.0008905570 4.941972e-04 2.137782e-03 11 65658718 65658729 12 - 2.466 2.396 -0.233
ENSG00000173039 E019 276.8644942 0.0013258200 1.114670e-04 5.744583e-04 11 65658730 65658731 2 - 2.442 2.352 -0.298
ENSG00000173039 E020 357.1466912 0.0008116268 9.584434e-04 3.816268e-03 11 65658732 65658768 37 - 2.531 2.472 -0.197
ENSG00000173039 E021 417.2970478 0.0003100797 1.624945e-03 6.040837e-03 11 65658769 65658822 54 - 2.588 2.544 -0.146
ENSG00000173039 E022 276.8453811 0.0012342104 4.087477e-02 9.266223e-02 11 65659666 65659681 16 - 2.406 2.369 -0.124
ENSG00000173039 E023 379.9051580 0.0003702365 1.844842e-02 4.811595e-02 11 65659682 65659738 57 - 2.537 2.506 -0.102
ENSG00000173039 E024 245.6884743 0.0003184623 6.394669e-01 7.528514e-01 11 65659739 65659743 5 - 2.318 2.327 0.028
ENSG00000173039 E025 338.0534323 0.0001588340 1.925895e-01 3.170116e-01 11 65659744 65659788 45 - 2.470 2.462 -0.027
ENSG00000173039 E026 233.6116875 0.0016118681 5.041181e-01 6.400063e-01 11 65659789 65659797 9 - 2.305 2.306 0.002
ENSG00000173039 E027 9.0292914 0.0018652173 1.874401e-02 4.877006e-02 11 65659798 65660051 254 - 1.110 0.867 -0.902
ENSG00000173039 E028 4.3656410 0.0124265525 5.384880e-02 1.159854e-01 11 65660052 65660123 72 - 0.857 0.588 -1.107
ENSG00000173039 E029 290.2296990 0.0005626762 3.230052e-02 7.643217e-02 11 65660124 65660155 32 - 2.422 2.389 -0.111
ENSG00000173039 E030 221.2003217 0.0002223382 2.348138e-02 5.874479e-02 11 65660156 65660171 16 - 2.311 2.270 -0.136
ENSG00000173039 E031 211.2809987 0.0002237322 8.858143e-03 2.592736e-02 11 65660172 65660188 17 - 2.298 2.247 -0.172
ENSG00000173039 E032 215.2333194 0.0002156260 4.606875e-03 1.483937e-02 11 65660189 65660215 27 - 2.310 2.253 -0.189
ENSG00000173039 E033 35.6793523 0.0006032188 1.964455e-08 2.294311e-07 11 65660216 65660792 577 - 1.713 1.394 -1.089
ENSG00000173039 E034 15.4390406 0.0261418070 2.630087e-04 1.228881e-03 11 65661408 65661510 103 - 1.411 1.014 -1.411
ENSG00000173039 E035 11.1180827 0.0144657327 3.101181e-03 1.056349e-02 11 65661511 65661632 122 - 1.231 0.915 -1.148
ENSG00000173039 E036 8.2093760 0.0026667200 1.751433e-03 6.445043e-03 11 65661633 65661686 54 - 1.127 0.788 -1.273
ENSG00000173039 E037 421.3581670 0.0005839076 2.139382e-04 1.023820e-03 11 65661687 65661819 133 - 2.602 2.543 -0.198
ENSG00000173039 E038 224.2031357 0.0008284266 1.341859e-05 8.652524e-05 11 65661820 65661835 16 - 2.361 2.257 -0.349
ENSG00000173039 E039 5.8226394 0.0087954561 1.570463e-02 4.207423e-02 11 65661836 65661868 33 - 0.990 0.689 -1.174
ENSG00000173039 E040 5.2670414 0.0030475977 1.133470e-01 2.103984e-01 11 65661869 65661936 68 - 0.887 0.690 -0.786
ENSG00000173039 E041 206.3767672 0.0002298412 4.522352e-04 1.975480e-03 11 65661937 65661942 6 - 2.305 2.229 -0.256
ENSG00000173039 E042 402.5893714 0.0017489970 5.008272e-04 2.163202e-03 11 65661943 65662088 146 - 2.593 2.520 -0.243
ENSG00000173039 E043 4.1956161 0.0209242500 9.969778e-02 1.900184e-01 11 65662089 65662178 90 - 0.825 0.589 -0.981
ENSG00000173039 E044 180.6634352 0.0051070066 6.320907e-03 1.945946e-02 11 65662179 65662205 27 - 2.264 2.166 -0.328
ENSG00000173039 E045 11.0160482 0.0578140213 1.890085e-02 4.911676e-02 11 65662206 65662347 142 - 1.230 0.910 -1.166
ENSG00000173039 E046 3.8184636 0.3154808078 6.746407e-01 7.801059e-01 11 65662348 65662378 31 - 0.787 0.566 -0.934
ENSG00000173039 E047 6.5756825 0.0185099361 3.401761e-02 7.979465e-02 11 65662379 65662664 286 - 1.012 0.741 -1.042
ENSG00000173039 E048 0.0000000       11 65662665 65662709 45 -      
ENSG00000173039 E049 1.1018414 0.0115636053 5.387291e-01 6.701332e-01 11 65662710 65662825 116 - 0.181 0.307 0.991
ENSG00000173039 E050 192.4259817 0.0046244095 1.764440e-02 4.637007e-02 11 65662826 65663090 265 - 2.275 2.198 -0.257
ENSG00000173039 E051 3.2304967 0.1361390576 4.607779e-01 6.007658e-01 11 65663170 65663219 50 - 0.406 0.602 0.954