ENSG00000173020

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000308595 ENSG00000173020 HEK293_OSMI2_2hA HEK293_TMG_2hB GRK2 protein_coding protein_coding 53.59244 80.39254 39.1975 6.266557 0.9267112 -1.036111 42.590252 70.4219094 26.827749 4.9544430 0.4902854 -1.391966 0.7727792 0.87710000 0.68546667 -0.19163333 8.178468e-09 8.178468e-09 FALSE TRUE
ENST00000532099 ENSG00000173020 HEK293_OSMI2_2hA HEK293_TMG_2hB GRK2 protein_coding processed_transcript 53.59244 80.39254 39.1975 6.266557 0.9267112 -1.036111 2.404511 0.8850307 3.345705 0.1928208 0.7790641 1.906607 0.0551125 0.01133333 0.08586667 0.07453333 2.090866e-05 8.178468e-09 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000173020 E001 6.1047268 0.0800076401 8.617008e-11 1.538176e-09 11 67266473 67266480 8 + 1.321 0.151 -5.589
ENSG00000173020 E002 156.2533969 0.0076450367 2.052787e-10 3.431521e-09 11 67266481 67266812 332 + 2.339 2.033 -1.023
ENSG00000173020 E003 0.3729606 0.0293404303 4.923347e-01 6.295184e-01 11 67270938 67271008 71 + 0.180 0.082 -1.307
ENSG00000173020 E004 6.2366096 0.0057854911 3.085327e-01 4.508233e-01 11 67276537 67277271 735 + 0.884 0.761 -0.484
ENSG00000173020 E005 220.0811886 0.0009476212 1.032639e-09 1.528004e-08 11 67277272 67277348 77 + 2.393 2.231 -0.541
ENSG00000173020 E006 287.8265278 0.0009738011 3.828673e-06 2.797588e-05 11 67279200 67279273 74 + 2.471 2.363 -0.359
ENSG00000173020 E007 320.2615446 0.0027058279 7.873326e-03 2.346160e-02 11 67279418 67279473 56 + 2.493 2.424 -0.230
ENSG00000173020 E008 318.3666761 0.0005189285 1.435967e-02 3.904575e-02 11 67279474 67279519 46 + 2.469 2.426 -0.145
ENSG00000173020 E009 444.6599775 0.0001633488 3.579988e-05 2.087659e-04 11 67279626 67279700 75 + 2.629 2.565 -0.212
ENSG00000173020 E010 413.0967206 0.0003881705 7.409186e-07 6.331581e-06 11 67279839 67279900 62 + 2.614 2.527 -0.292
ENSG00000173020 E011 3.0174641 0.0052555053 3.294798e-04 1.498726e-03 11 67280194 67280731 538 + 0.884 0.350 -2.425
ENSG00000173020 E012 376.1645518 0.0006336604 2.835004e-06 2.133737e-05 11 67280732 67280783 52 + 2.577 2.486 -0.304
ENSG00000173020 E013 13.1502923 0.0053997712 4.334637e-10 6.864365e-09 11 67280784 67281092 309 + 1.442 0.858 -2.103
ENSG00000173020 E014 473.7197586 0.0001440884 3.681475e-04 1.651075e-03 11 67281093 67281184 92 + 2.647 2.596 -0.169
ENSG00000173020 E015 370.6976366 0.0001455092 4.661968e-03 1.499025e-02 11 67281459 67281508 50 + 2.535 2.491 -0.146
ENSG00000173020 E016 306.3989025 0.0001511490 1.736771e-02 4.575080e-02 11 67281509 67281558 50 + 2.450 2.410 -0.131
ENSG00000173020 E017 304.5402458 0.0001515581 7.633598e-05 4.106694e-04 11 67281650 67281683 34 + 2.472 2.397 -0.249
ENSG00000173020 E018 397.7246094 0.0002304037 6.391724e-07 5.535510e-06 11 67281684 67281728 45 + 2.595 2.509 -0.287
ENSG00000173020 E019 410.1455609 0.0005588938 4.972469e-07 4.399081e-06 11 67281822 67281875 54 + 2.617 2.523 -0.312
ENSG00000173020 E020 435.6261284 0.0001480445 2.597795e-03 9.058928e-03 11 67281876 67281952 77 + 2.604 2.561 -0.143
ENSG00000173020 E021 15.7676883 0.0506714697 1.624946e-05 1.028778e-04 11 67281953 67282124 172 + 1.515 0.930 -2.077
ENSG00000173020 E022 14.5665393 0.0017670802 3.932273e-10 6.279671e-09 11 67282125 67282270 146 + 1.457 0.916 -1.934
ENSG00000173020 E023 493.3107560 0.0001842203 5.342275e-01 6.663141e-01 11 67282271 67282365 95 + 2.606 2.633 0.091
ENSG00000173020 E024 7.5307314 0.0123676435 1.043594e-03 4.109537e-03 11 67282366 67282434 69 + 1.124 0.729 -1.496
ENSG00000173020 E025 352.1647617 0.0001507778 9.284393e-02 1.795749e-01 11 67282435 67282477 43 + 2.441 2.494 0.175
ENSG00000173020 E026 418.0182568 0.0001351003 5.881470e-01 7.113706e-01 11 67282478 67282542 65 + 2.536 2.562 0.087
ENSG00000173020 E027 310.3816520 0.0002496940 5.722312e-02 1.218486e-01 11 67282752 67282780 29 + 2.381 2.442 0.204
ENSG00000173020 E028 350.1195598 0.0001634731 4.617641e-01 6.016825e-01 11 67282781 67282818 38 + 2.455 2.487 0.105
ENSG00000173020 E029 324.4396995 0.0002033186 8.780588e-01 9.256852e-01 11 67283128 67283174 47 + 2.432 2.451 0.062
ENSG00000173020 E030 341.3640756 0.0057477045 4.745333e-01 6.133639e-01 11 67283175 67283228 54 + 2.434 2.482 0.161
ENSG00000173020 E031 10.5041886 0.0015970305 1.679526e-06 1.328079e-05 11 67283229 67283706 478 + 1.300 0.832 -1.712
ENSG00000173020 E032 399.0298119 0.0034277489 5.439195e-01 6.744550e-01 11 67283707 67283773 67 + 2.508 2.547 0.129
ENSG00000173020 E033 5.8824301 0.0964517388 9.777641e-03 2.821503e-02 11 67283774 67283853 80 + 1.089 0.610 -1.877
ENSG00000173020 E034 531.8370895 0.0001110873 7.576086e-01 8.423619e-01 11 67283854 67283949 96 + 2.653 2.662 0.032
ENSG00000173020 E035 36.8065037 0.0007629336 5.920093e-18 2.982036e-16 11 67283950 67284210 261 + 1.820 1.332 -1.669
ENSG00000173020 E036 470.5272381 0.0001524445 1.640378e-01 2.804053e-01 11 67284211 67284270 60 + 2.615 2.604 -0.036
ENSG00000173020 E037 581.7017183 0.0001302440 1.474142e-01 2.581762e-01 11 67284271 67284373 103 + 2.669 2.709 0.135
ENSG00000173020 E038 19.3313616 0.0010439289 4.301239e-06 3.105636e-05 11 67284374 67284622 249 + 1.473 1.121 -1.233
ENSG00000173020 E039 615.7148125 0.0001277669 3.887620e-04 1.731266e-03 11 67284847 67284983 137 + 2.664 2.740 0.253
ENSG00000173020 E040 38.7892333 0.0005655029 2.562398e-01 3.932148e-01 11 67284984 67285074 91 + 1.573 1.517 -0.192
ENSG00000173020 E041 583.4261900 0.0007780839 1.535996e-06 1.224911e-05 11 67285075 67285188 114 + 2.605 2.728 0.407
ENSG00000173020 E042 1500.9499889 0.0014918876 2.296885e-25 2.596288e-23 11 67285286 67286055 770 + 2.926 3.161 0.783
ENSG00000173020 E043 701.2530689 0.0021732401 3.018418e-20 1.982081e-18 11 67286056 67286392 337 + 2.559 2.838 0.928
ENSG00000173020 E044 233.0421584 0.0002092995 1.100036e-12 2.678310e-11 11 67286393 67286556 164 + 2.126 2.349 0.746