ENSG00000173011

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000310074 ENSG00000173011 HEK293_OSMI2_2hA HEK293_TMG_2hB TADA2B protein_coding protein_coding 15.73295 20.7597 12.77781 0.5124883 0.4065446 -0.6997106 8.727473 8.946856 9.92039683 0.9811481 0.45439104 0.1488589 0.56613750 0.4308 0.776566667 0.3457667 3.344966e-06 3.344966e-06 FALSE TRUE
ENST00000512388 ENSG00000173011 HEK293_OSMI2_2hA HEK293_TMG_2hB TADA2B protein_coding protein_coding 15.73295 20.7597 12.77781 0.5124883 0.4065446 -0.6997106 5.206817 8.631089 2.17070917 1.1718717 0.46628023 -1.9864157 0.32697917 0.4159 0.170466667 -0.2454333 1.306734e-02 3.344966e-06 FALSE TRUE
MSTRG.24544.4 ENSG00000173011 HEK293_OSMI2_2hA HEK293_TMG_2hB TADA2B protein_coding   15.73295 20.7597 12.77781 0.5124883 0.4065446 -0.6997106 1.173143 2.365901 0.09246059 0.1581561 0.09246059 -4.5353340 0.06666667 0.1138 0.007033333 -0.1067667 9.212452e-03 3.344966e-06 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000173011 E001 0.000000       4 7041899 7042086 188 +      
ENSG00000173011 E002 5.383917 0.138776477 1.437426e-02 3.907758e-02 4 7043372 7043534 163 + 1.042 0.534 -2.049
ENSG00000173011 E003 8.021039 0.024514748 4.099587e-01 5.535788e-01 4 7043535 7043581 47 + 0.994 0.908 -0.320
ENSG00000173011 E004 36.911763 0.006986732 3.064645e-01 4.486387e-01 4 7043582 7043624 43 + 1.585 1.539 -0.158
ENSG00000173011 E005 105.957811 0.003445569 8.976164e-04 3.605902e-03 4 7043625 7043849 225 + 2.080 1.963 -0.392
ENSG00000173011 E006 4.776930 0.003321853 6.060595e-03 1.876940e-02 4 7048463 7048518 56 + 0.417 0.864 1.971
ENSG00000173011 E007 5.849711 0.003137159 2.400868e-06 1.835502e-05 4 7048869 7048958 90 + 0.147 0.962 4.342
ENSG00000173011 E008 8.692769 0.002007468 1.649855e-02 4.384223e-02 4 7052824 7053352 529 + 0.735 1.052 1.213
ENSG00000173011 E009 4.978973 0.003337365 9.908300e-01 9.984403e-01 4 7053353 7053501 149 + 0.735 0.759 0.098
ENSG00000173011 E010 9.121370 0.002248597 8.960688e-01 9.375783e-01 4 7053502 7054061 560 + 0.976 0.986 0.039
ENSG00000173011 E011 1716.677637 0.005307341 5.598443e-02 1.196710e-01 4 7054062 7057952 3891 + 3.192 3.227 0.117