ENSG00000172992

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000342350 ENSG00000172992 HEK293_OSMI2_2hA HEK293_TMG_2hB DCAKD protein_coding protein_coding 41.86874 59.10036 27.52501 2.374501 0.5090978 -1.102144 18.114189 24.981583 7.882766 1.9381265 1.0202912 -1.6628393 0.42319167 0.4218667 0.2867000 -0.13516667 0.0879292763 1.059025e-14 FALSE TRUE
ENST00000452796 ENSG00000172992 HEK293_OSMI2_2hA HEK293_TMG_2hB DCAKD protein_coding protein_coding 41.86874 59.10036 27.52501 2.374501 0.5090978 -1.102144 10.932510 21.614096 6.274756 1.3110815 0.3543714 -1.7827112 0.24184167 0.3672667 0.2285333 -0.13873333 0.0086089341 1.059025e-14 FALSE TRUE
ENST00000588499 ENSG00000172992 HEK293_OSMI2_2hA HEK293_TMG_2hB DCAKD protein_coding protein_coding 41.86874 59.10036 27.52501 2.374501 0.5090978 -1.102144 1.910347 1.023390 2.679311 0.4075738 0.1779473 1.3798521 0.05698333 0.0168000 0.0972000 0.08040000 0.0002757189 1.059025e-14 FALSE TRUE
ENST00000651974 ENSG00000172992 HEK293_OSMI2_2hA HEK293_TMG_2hB DCAKD protein_coding protein_coding 41.86874 59.10036 27.52501 2.374501 0.5090978 -1.102144 4.023223 5.409532 3.145202 0.3238946 0.4489387 -0.7804361 0.09510000 0.0914000 0.1138667 0.02246667 0.5600801257 1.059025e-14 FALSE TRUE
MSTRG.14485.1 ENSG00000172992 HEK293_OSMI2_2hA HEK293_TMG_2hB DCAKD protein_coding   41.86874 59.10036 27.52501 2.374501 0.5090978 -1.102144 1.567532 0.000000 2.663245 0.0000000 1.3704484 8.0624482 0.04926250 0.0000000 0.0955000 0.09550000 0.1220638979 1.059025e-14 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000172992 E001 0.7374030 0.0156051054 9.205496e-03 2.679831e-02 17 45008473 45008509 37 - 0.530 0.071 -3.757
ENSG00000172992 E002 0.4502799 0.0384874397 7.305170e-03 2.201312e-02 17 45012015 45012070 56 - 0.446 0.000 -15.695
ENSG00000172992 E003 0.4439371 0.0215823979 6.890052e-03 2.093940e-02 17 45013487 45013594 108 - 0.446 0.000 -15.967
ENSG00000172992 E004 0.5975289 0.0360080680 1.685741e-03 6.237551e-03 17 45013798 45013937 140 - 0.531 0.000 -16.133
ENSG00000172992 E005 1.0329452 0.0119874792 9.029308e-03 2.635181e-02 17 45017035 45017158 124 - 0.601 0.132 -3.080
ENSG00000172992 E006 1.2845899 0.0108647759 9.961205e-02 1.898855e-01 17 45023338 45023339 2 - 0.000 0.350 14.462
ENSG00000172992 E007 1.9101297 0.0081333665 2.038134e-01 3.309803e-01 17 45023340 45023343 4 - 0.204 0.443 1.566
ENSG00000172992 E008 4.3298850 0.0043430236 3.757084e-02 8.653086e-02 17 45023344 45023345 2 - 0.342 0.705 1.767
ENSG00000172992 E009 4.9230577 0.0048233344 1.582628e-02 4.234983e-02 17 45023346 45023347 2 - 0.342 0.761 1.997
ENSG00000172992 E010 208.5162291 0.0080083412 7.213090e-04 2.975046e-03 17 45023348 45023455 108 - 2.094 2.251 0.525
ENSG00000172992 E011 338.9770550 0.0101377961 2.278631e-06 1.750456e-05 17 45023456 45023571 116 - 2.237 2.470 0.778
ENSG00000172992 E012 248.8315772 0.0038296962 7.593531e-11 1.365516e-09 17 45023572 45023606 35 - 2.090 2.340 0.836
ENSG00000172992 E013 169.0260764 0.0059207438 9.385670e-17 4.056781e-15 17 45023607 45023634 28 - 1.748 2.193 1.493
ENSG00000172992 E014 71.6944718 0.0003963438 8.506274e-07 7.173647e-06 17 45023635 45023635 1 - 1.552 1.802 0.846
ENSG00000172992 E015 77.9472449 0.0003692196 1.811463e-08 2.128488e-07 17 45023636 45023637 2 - 1.560 1.841 0.954
ENSG00000172992 E016 83.8406762 0.0007922109 3.230390e-09 4.357025e-08 17 45023638 45023640 3 - 1.581 1.875 0.997
ENSG00000172992 E017 88.9980247 0.0018213849 5.129852e-10 8.011170e-09 17 45023641 45023644 4 - 1.581 1.903 1.091
ENSG00000172992 E018 89.2723869 0.0009110983 3.295447e-11 6.303004e-10 17 45023645 45023649 5 - 1.574 1.906 1.124
ENSG00000172992 E019 93.5305288 0.0005002830 2.901468e-11 5.602633e-10 17 45023650 45023655 6 - 1.607 1.923 1.067
ENSG00000172992 E020 268.3139907 0.0002217787 3.233712e-04 1.474363e-03 17 45023656 45023709 54 - 2.276 2.344 0.227
ENSG00000172992 E021 292.7994680 0.0008540256 2.362315e-01 3.698135e-01 17 45023710 45023741 32 - 2.366 2.370 0.013
ENSG00000172992 E022 951.2855074 0.0011551514 3.705573e-01 5.149823e-01 17 45023742 45024372 631 - 2.915 2.870 -0.151
ENSG00000172992 E023 464.0124249 0.0033824152 3.022368e-04 1.388675e-03 17 45024373 45024724 352 - 2.678 2.535 -0.477
ENSG00000172992 E024 3.8739097 0.0042558890 1.141876e-01 2.116518e-01 17 45026768 45026817 50 - 0.805 0.542 -1.118
ENSG00000172992 E025 1.2523272 0.0102185626 2.269994e-02 5.712967e-02 17 45029393 45029399 7 - 0.601 0.185 -2.493
ENSG00000172992 E026 4.4212155 0.0035279944 7.426329e-03 2.232707e-02 17 45029400 45029571 172 - 0.943 0.541 -1.649
ENSG00000172992 E027 265.0654709 0.0014797341 5.246233e-11 9.703994e-10 17 45030092 45030179 88 - 2.492 2.271 -0.739
ENSG00000172992 E028 0.2965864 0.1877104140 8.462538e-01   17 45030180 45030303 124 - 0.000 0.129 11.814
ENSG00000172992 E029 0.6568746 0.0206497948 1.000000e+00 1.000000e+00 17 45030304 45030442 139 - 0.204 0.185 -0.172
ENSG00000172992 E030 0.9963223 0.0158371172 1.436214e-01 2.529342e-01 17 45030443 45030558 116 - 0.000 0.314 14.166
ENSG00000172992 E031 0.1472490 0.0431646422 1.461371e-01   17 45031940 45031951 12 - 0.204 0.000 -14.072
ENSG00000172992 E032 0.6255398 0.0181172519 9.961074e-01 1.000000e+00 17 45031952 45032048 97 - 0.204 0.185 -0.173
ENSG00000172992 E033 1.4079055 0.2622282948 9.927236e-01 9.995456e-01 17 45032049 45032121 73 - 0.342 0.340 -0.017
ENSG00000172992 E034 0.4782907 0.0215877566 4.588520e-01 5.991023e-01 17 45032122 45032391 270 - 0.000 0.185 13.111
ENSG00000172992 E035 0.1472490 0.0431646422 1.461371e-01   17 45032392 45032618 227 - 0.204 0.000 -14.072
ENSG00000172992 E036 1.2501346 0.0108674561 5.274971e-01 6.605514e-01 17 45033044 45033934 891 - 0.204 0.315 0.830
ENSG00000172992 E037 11.5930760 0.0015130528 3.635110e-03 1.211215e-02 17 45033935 45034042 108 - 1.249 0.926 -1.171
ENSG00000172992 E038 434.0895202 0.0050040046 7.141143e-09 9.042327e-08 17 45034187 45034390 204 - 2.719 2.480 -0.796
ENSG00000172992 E039 471.9466294 0.0055002594 1.859771e-06 1.457300e-05 17 45034774 45034999 226 - 2.731 2.526 -0.684
ENSG00000172992 E040 11.1307115 0.0092010086 6.711642e-01 7.774631e-01 17 45035000 45035002 3 - 1.048 0.971 -0.285
ENSG00000172992 E041 2.6904958 0.0056089318 2.372626e-01 3.710076e-01 17 45035003 45035548 546 - 0.662 0.443 -1.019
ENSG00000172992 E042 1.1050505 0.1184505630 6.433780e-01 7.559480e-01 17 45044391 45044614 224 - 0.341 0.236 -0.731
ENSG00000172992 E043 0.4428904 0.4992300767 9.404996e-01 9.666297e-01 17 45044615 45044664 50 - 0.000 0.138 11.640
ENSG00000172992 E044 2.8440995 0.0059846237 6.162897e-01 7.343769e-01 17 45051065 45051360 296 - 0.601 0.495 -0.494
ENSG00000172992 E045 43.1984358 0.0005132701 1.491707e-04 7.434676e-04 17 45051361 45051552 192 - 1.734 1.485 -0.847
ENSG00000172992 E046 57.7260774 0.0067089509 3.590774e-02 8.340217e-02 17 45051553 45051680 128 - 1.792 1.628 -0.557
ENSG00000172992 E047 0.2955422 0.0293589923 4.013779e-01   17 45060416 45060440 25 - 0.204 0.071 -1.758
ENSG00000172992 E048 0.4772466 0.0204897774 7.027284e-01 8.015217e-01 17 45060441 45060483 43 - 0.204 0.132 -0.757
ENSG00000172992 E049 1.8820065 0.0347504136 6.514014e-02 1.352721e-01 17 45060628 45060887 260 - 0.662 0.313 -1.763
ENSG00000172992 E050 139.3961460 0.0055226266 1.302925e-04 6.600933e-04 17 45060888 45061074 187 - 2.209 1.997 -0.710
ENSG00000172992 E051 18.0471621 0.0051205981 1.949372e-01 3.199088e-01 17 45061075 45061131 57 - 1.304 1.155 -0.527