ENSG00000172954

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000379509 ENSG00000172954 HEK293_OSMI2_2hA HEK293_TMG_2hB LCLAT1 protein_coding protein_coding 11.34037 4.453997 16.16637 0.4575098 0.5228742 1.85748 7.7485505 3.63578579 9.2162324 0.51228957 0.7542859 1.339512 0.75339583 0.811766667 0.5693333 -0.24243333 0.040859403 0.000301669 FALSE TRUE
ENST00000465200 ENSG00000172954 HEK293_OSMI2_2hA HEK293_TMG_2hB LCLAT1 protein_coding protein_coding 11.34037 4.453997 16.16637 0.4575098 0.5228742 1.85748 1.2064029 0.00000000 2.0313169 0.00000000 1.3463115 7.673356 0.06287917 0.000000000 0.1206000 0.12060000 0.350773795 0.000301669 FALSE FALSE
ENST00000466477 ENSG00000172954 HEK293_OSMI2_2hA HEK293_TMG_2hB LCLAT1 protein_coding protein_coding 11.34037 4.453997 16.16637 0.4575098 0.5228742 1.85748 0.4140903 0.00000000 0.8924743 0.00000000 0.2426674 6.495814 0.02308333 0.000000000 0.0556000 0.05560000 0.000301669 0.000301669 FALSE TRUE
MSTRG.18158.10 ENSG00000172954 HEK293_OSMI2_2hA HEK293_TMG_2hB LCLAT1 protein_coding   11.34037 4.453997 16.16637 0.4575098 0.5228742 1.85748 0.3046407 0.02799369 1.2786113 0.02799369 0.3469226 5.083914 0.02403333 0.007266667 0.0806000 0.07333333 0.034639155 0.000301669 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000172954 E001 0.2987644 0.0293548660 8.071927e-01   2 30447226 30447231 6 + 0.122 0.000 -10.170
ENSG00000172954 E002 0.4439371 0.0215703782 4.744780e-01 6.133092e-01 2 30447232 30447235 4 + 0.172 0.000 -11.892
ENSG00000172954 E003 0.5911862 0.0184889975 3.100221e-01 4.523890e-01 2 30447236 30447242 7 + 0.217 0.000 -12.314
ENSG00000172954 E004 0.5911862 0.0184889975 3.100221e-01 4.523890e-01 2 30447243 30447245 3 + 0.217 0.000 -12.314
ENSG00000172954 E005 1.4790604 0.0090460863 3.826315e-02 8.784235e-02 2 30447246 30447248 3 + 0.419 0.000 -13.609
ENSG00000172954 E006 1.4790604 0.0090460863 3.826315e-02 8.784235e-02 2 30447249 30447249 1 + 0.419 0.000 -13.609
ENSG00000172954 E007 1.7714822 0.0080178709 2.036508e-02 5.225446e-02 2 30447250 30447255 6 + 0.469 0.000 -13.843
ENSG00000172954 E008 4.5717449 0.0043423891 7.496455e-05 4.040459e-04 2 30447256 30447256 1 + 0.780 0.000 -14.947
ENSG00000172954 E009 9.3346694 0.0021682269 1.881711e-04 9.131499e-04 2 30447257 30447272 16 + 1.024 0.557 -1.876
ENSG00000172954 E010 9.4861848 0.0018852706 1.474031e-04 7.359357e-04 2 30447273 30447275 3 + 1.031 0.557 -1.900
ENSG00000172954 E011 28.8336255 0.0031683208 1.374616e-06 1.107922e-05 2 30447276 30447383 108 + 1.464 1.127 -1.180
ENSG00000172954 E012 4.9705394 0.0434049995 1.373187e-01 2.443421e-01 2 30447384 30447387 4 + 0.756 0.557 -0.851
ENSG00000172954 E013 5.4112543 0.0384467436 1.892968e-01 3.128447e-01 2 30447388 30447402 15 + 0.780 0.629 -0.628
ENSG00000172954 E014 4.3062899 0.0128836921 1.749696e-02 4.603816e-02 2 30447403 30447404 2 + 0.731 0.363 -1.748
ENSG00000172954 E015 0.8889184 0.0134891791 6.702114e-01 7.767174e-01 2 30447405 30447523 119 + 0.258 0.218 -0.316
ENSG00000172954 E016 5.3718296 0.0117992358 1.797886e-02 4.708899e-02 2 30459552 30459722 171 + 0.803 0.471 -1.452
ENSG00000172954 E017 0.0000000       2 30476402 30476576 175 +      
ENSG00000172954 E018 4.0590438 0.0043509461 9.026889e-01 9.420368e-01 2 30476577 30476635 59 + 0.628 0.692 0.271
ENSG00000172954 E019 0.2924217 0.0271797429 8.085973e-01   2 30489160 30489240 81 + 0.122 0.000 -11.279
ENSG00000172954 E020 68.5156470 0.0018627071 1.674630e-12 3.954301e-11 2 30525587 30525755 169 + 1.827 1.509 -1.082
ENSG00000172954 E021 86.2757199 0.0003161574 2.643346e-17 1.220210e-15 2 30533116 30533314 199 + 1.924 1.604 -1.083
ENSG00000172954 E022 0.0000000       2 30533315 30533319 5 +      
ENSG00000172954 E023 2.3510270 0.0164986167 6.251088e-02 1.308694e-01 2 30552493 30552649 157 + 0.536 0.218 -1.900
ENSG00000172954 E024 61.8889086 0.0004379358 1.175702e-08 1.431080e-07 2 30562146 30562292 147 + 1.769 1.551 -0.741
ENSG00000172954 E025 26.2697540 0.0007785598 9.579369e-04 3.814612e-03 2 30568060 30568066 7 + 1.398 1.222 -0.617
ENSG00000172954 E026 56.1779019 0.0004863042 3.728344e-07 3.383087e-06 2 30568067 30568176 110 + 1.722 1.527 -0.666
ENSG00000172954 E027 1.9250739 0.0077766838 1.493513e-02 4.033897e-02 2 30606016 30607845 1830 + 0.493 0.000 -13.942
ENSG00000172954 E028 704.1755407 0.0022624942 1.152608e-50 7.278602e-48 2 30640117 30644225 4109 + 2.700 2.963 0.873