ENSG00000172943

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000338154 ENSG00000172943 HEK293_OSMI2_2hA HEK293_TMG_2hB PHF8 protein_coding protein_coding 28.96783 36.49811 25.22327 1.478582 0.5573747 -0.5328901 3.124879 2.444142 2.771513 0.9285569 1.1382385 0.1806512 0.11541250 0.06520000 0.1087667 0.04356667 7.201632e-01 6.415966e-36 FALSE TRUE
ENST00000338946 ENSG00000172943 HEK293_OSMI2_2hA HEK293_TMG_2hB PHF8 protein_coding protein_coding 28.96783 36.49811 25.22327 1.478582 0.5573747 -0.5328901 8.495179 8.206945 9.075629 1.2353203 0.2790629 0.1449843 0.29762917 0.22353333 0.3606000 0.13706667 2.815684e-02 6.415966e-36 FALSE TRUE
ENST00000396282 ENSG00000172943 HEK293_OSMI2_2hA HEK293_TMG_2hB PHF8 protein_coding protein_coding 28.96783 36.49811 25.22327 1.478582 0.5573747 -0.5328901 1.329489 0.000000 2.461602 0.0000000 0.3812490 7.9493026 0.05590833 0.00000000 0.0983000 0.09830000 1.421157e-21 6.415966e-36 FALSE TRUE
ENST00000687283 ENSG00000172943 HEK293_OSMI2_2hA HEK293_TMG_2hB PHF8 protein_coding retained_intron 28.96783 36.49811 25.22327 1.478582 0.5573747 -0.5328901 2.924471 9.461221 0.000000 1.3520032 0.0000000 -9.8874067 0.08514167 0.26283333 0.0000000 -0.26283333 5.589790e-23 6.415966e-36 FALSE TRUE
ENST00000691629 ENSG00000172943 HEK293_OSMI2_2hA HEK293_TMG_2hB PHF8 protein_coding processed_transcript 28.96783 36.49811 25.22327 1.478582 0.5573747 -0.5328901 2.365897 4.930366 0.000000 0.3196153 0.0000000 -8.9484740 0.06905000 0.13563333 0.0000000 -0.13563333 6.415966e-36 6.415966e-36 FALSE TRUE
MSTRG.34303.10 ENSG00000172943 HEK293_OSMI2_2hA HEK293_TMG_2hB PHF8 protein_coding   28.96783 36.49811 25.22327 1.478582 0.5573747 -0.5328901 0.710080 2.002391 0.000000 0.4858995 0.0000000 -7.6527665 0.02049583 0.05413333 0.0000000 -0.05413333 2.448923e-12 6.415966e-36 FALSE TRUE
MSTRG.34303.12 ENSG00000172943 HEK293_OSMI2_2hA HEK293_TMG_2hB PHF8 protein_coding   28.96783 36.49811 25.22327 1.478582 0.5573747 -0.5328901 6.076134 5.265276 6.769867 0.6068731 0.8299510 0.3620104 0.21353750 0.14446667 0.2692333 0.12476667 3.230318e-02 6.415966e-36 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000172943 E001 5.4990943 0.0039653357 4.507577e-01 5.917941e-01 X 53936676 53936679 4 - 0.716 0.835 0.475
ENSG00000172943 E002 10.5371357 0.0016102479 6.228654e-03 1.921573e-02 X 53936680 53936693 14 - 0.828 1.147 1.189
ENSG00000172943 E003 10.6112327 0.0017880731 1.095856e-02 3.106396e-02 X 53936694 53936704 11 - 0.852 1.147 1.095
ENSG00000172943 E004 194.9150652 0.0047828305 1.364619e-22 1.160858e-20 X 53936705 53936910 206 - 1.935 2.401 1.559
ENSG00000172943 E005 90.9966524 0.0016859021 1.034516e-17 5.073413e-16 X 53936911 53936913 3 - 1.641 2.064 1.426
ENSG00000172943 E006 143.1120681 0.0065790527 1.728934e-12 4.071872e-11 X 53936914 53936951 38 - 1.862 2.253 1.311
ENSG00000172943 E007 745.7832568 0.0042728704 6.564392e-16 2.541079e-14 X 53936952 53937497 546 - 2.657 2.947 0.964
ENSG00000172943 E008 332.7526722 0.0028643027 5.097097e-09 6.640738e-08 X 53937498 53937648 151 - 2.366 2.579 0.710
ENSG00000172943 E009 561.3611632 0.0035192077 6.138058e-06 4.283323e-05 X 53937649 53938059 411 - 2.627 2.792 0.549
ENSG00000172943 E010 677.7215199 0.0003181707 7.975761e-16 3.050028e-14 X 53938060 53939161 1102 - 2.718 2.868 0.497
ENSG00000172943 E011 186.4479128 0.0006280624 2.337221e-02 5.852304e-02 X 53939162 53939246 85 - 2.204 2.291 0.288
ENSG00000172943 E012 263.5691795 0.0016089084 3.364693e-01 4.803151e-01 X 53940180 53940368 189 - 2.379 2.428 0.163
ENSG00000172943 E013 211.5187372 0.0002315794 3.403422e-02 7.982570e-02 X 53940369 53940516 148 - 2.266 2.341 0.250
ENSG00000172943 E014 2.7949852 0.0055179872 1.453718e-01 2.553641e-01 X 53942618 53943255 638 - 0.683 0.469 -0.972
ENSG00000172943 E015 1.7693146 0.0077935521 3.713966e-01 5.158356e-01 X 53943256 53943402 147 - 0.517 0.378 -0.722
ENSG00000172943 E016 150.6386784 0.0002336817 6.273655e-03 1.932970e-02 X 53944134 53944243 110 - 2.099 2.203 0.346
ENSG00000172943 E017 0.8846626 0.0143105401 3.242397e-01 4.676086e-01 X 53944244 53944564 321 - 0.140 0.324 1.542
ENSG00000172943 E018 145.4783713 0.0002274057 2.079444e-01 3.360213e-01 X 53962844 53962939 96 - 2.115 2.174 0.197
ENSG00000172943 E019 0.1817044 0.0389708085 6.709895e-01   X 53962940 53963049 110 - 0.000 0.106 9.097
ENSG00000172943 E020 316.0354892 0.0002202763 8.515560e-01 9.079509e-01 X 53984914 53985227 314 - 2.477 2.493 0.055
ENSG00000172943 E021 20.2380319 0.0019767980 2.365744e-04 1.118919e-03 X 53985228 53985744 517 - 1.454 1.189 -0.927
ENSG00000172943 E022 4.9261753 0.0543339270 2.405880e-02 5.993566e-02 X 53985745 53985784 40 - 0.936 0.581 -1.442
ENSG00000172943 E023 3.3384658 0.0090618986 1.467931e-03 5.533131e-03 X 53985785 53985815 31 - 0.852 0.378 -2.136
ENSG00000172943 E024 174.9652361 0.0002423373 1.066870e-01 2.006585e-01 X 53985816 53985906 91 - 2.246 2.221 -0.082
ENSG00000172943 E025 160.7309123 0.0002251315 1.482923e-02 4.010612e-02 X 53985907 53985949 43 - 2.224 2.174 -0.166
ENSG00000172943 E026 199.0474816 0.0002934624 2.907985e-03 9.993270e-03 X 53987078 53987163 86 - 2.321 2.263 -0.193
ENSG00000172943 E027 142.4865642 0.0025215906 1.126040e-02 3.178568e-02 X 53987766 53987786 21 - 2.189 2.111 -0.261
ENSG00000172943 E028 306.4060506 0.0013351858 4.306620e-04 1.892326e-03 X 53987787 53987944 158 - 2.517 2.443 -0.246
ENSG00000172943 E029 199.6279963 0.0014743343 1.101897e-05 7.249814e-05 X 53992736 53992793 58 - 2.356 2.243 -0.380
ENSG00000172943 E030 145.6187675 0.0056601990 3.286558e-03 1.111089e-02 X 53992794 53992801 8 - 2.219 2.107 -0.375
ENSG00000172943 E031 169.8002216 0.0070227670 2.812461e-02 6.826026e-02 X 53992802 53992839 38 - 2.267 2.187 -0.268
ENSG00000172943 E032 1.6576418 0.0084931899 6.808138e-02 1.401845e-01 X 53992840 53993009 170 - 0.565 0.263 -1.679
ENSG00000172943 E033 250.8326877 0.0015259129 8.101814e-04 3.295044e-03 X 53993601 53993903 303 - 2.433 2.358 -0.251
ENSG00000172943 E034 1.1792493 0.0164294729 1.111893e-01 2.072949e-01 X 53995131 53995205 75 - 0.463 0.192 -1.777
ENSG00000172943 E035 189.7179593 0.0028266326 3.177925e-05 1.879563e-04 X 53995693 53995782 90 - 2.341 2.213 -0.426
ENSG00000172943 E036 0.0000000       X 53998155 53998286 132 -      
ENSG00000172943 E037 1.8651815 0.0791363042 5.805823e-01 7.052874e-01 X 53999487 53999869 383 - 0.516 0.423 -0.470
ENSG00000172943 E038 165.7895070 0.0016899171 2.382572e-04 1.126063e-03 X 53999870 53999961 92 - 2.269 2.168 -0.341
ENSG00000172943 E039 184.1073159 0.0005399143 2.002286e-06 1.557492e-05 X 54002155 54002261 107 - 2.321 2.209 -0.374
ENSG00000172943 E040 160.1706405 0.0014107097 2.527097e-03 8.843813e-03 X 54002595 54002682 88 - 2.242 2.164 -0.262
ENSG00000172943 E041 234.6256863 0.0017569838 1.942512e-03 7.048306e-03 X 54011122 54011284 163 - 2.401 2.328 -0.244
ENSG00000172943 E042 249.8139720 0.0018558383 9.801196e-05 5.127036e-04 X 54014377 54014563 187 - 2.441 2.344 -0.323
ENSG00000172943 E043 208.0017968 0.0002080846 2.576291e-08 2.940008e-07 X 54016595 54016736 142 - 2.375 2.256 -0.399
ENSG00000172943 E044 129.4886252 0.0002508004 1.874628e-06 1.467471e-05 X 54017661 54017736 76 - 2.179 2.049 -0.433
ENSG00000172943 E045 98.2232643 0.0026680098 2.009505e-04 9.678268e-04 X 54017737 54017769 33 - 2.065 1.927 -0.465
ENSG00000172943 E046 69.7011920 0.0059875018 1.225034e-02 3.413529e-02 X 54017770 54017770 1 - 1.905 1.788 -0.397
ENSG00000172943 E047 70.3539035 0.0047698640 4.694619e-03 1.508091e-02 X 54017771 54017778 8 - 1.915 1.787 -0.432
ENSG00000172943 E048 96.7595708 0.0024975841 3.748943e-04 1.676997e-03 X 54017779 54017821 43 - 2.055 1.925 -0.437
ENSG00000172943 E049 153.9525563 0.0002279019 1.770023e-12 4.163984e-11 X 54022259 54022367 109 - 2.281 2.098 -0.611
ENSG00000172943 E050 133.7731918 0.0016540195 1.683706e-11 3.378595e-10 X 54022758 54022843 86 - 2.238 2.017 -0.740
ENSG00000172943 E051 2.9452544 0.0147864136 3.232523e-01 4.665663e-01 X 54039630 54040072 443 - 0.682 0.543 -0.616
ENSG00000172943 E052 163.0232398 0.0040172843 2.584350e-06 1.962865e-05 X 54042631 54042809 179 - 2.298 2.128 -0.568
ENSG00000172943 E053 47.9864048 0.0170346435 2.141427e-01 3.434126e-01 X 54042810 54042820 11 - 1.720 1.650 -0.239
ENSG00000172943 E054 1.1362967 0.0121775378 2.346420e-02 5.871147e-02 X 54042821 54042836 16 - 0.000 0.426 12.107
ENSG00000172943 E055 1.2899771 0.0668359443 9.370543e-01 9.644325e-01 X 54042837 54042907 71 - 0.331 0.328 -0.023
ENSG00000172943 E056 0.8470867 0.0144106263 3.988995e-01 5.426485e-01 X 54042908 54043057 150 - 0.331 0.192 -1.042
ENSG00000172943 E057 1.0726991 0.0118147126 1.074205e-01 2.017397e-01 X 54043058 54043110 53 - 0.464 0.192 -1.781
ENSG00000172943 E058 1.8509002 0.0079744758 7.683281e-02 1.544294e-01 X 54043111 54043194 84 - 0.608 0.324 -1.460
ENSG00000172943 E059 60.8698098 0.0078573882 4.424001e-03 1.432932e-02 X 54043762 54043811 50 - 1.864 1.712 -0.512
ENSG00000172943 E060 118.2674241 0.0236317344 6.638732e-03 2.028576e-02 X 54043812 54044015 204 - 2.168 1.981 -0.627
ENSG00000172943 E061 99.5568502 0.0240330245 3.323597e-03 1.121643e-02 X 54044016 54044517 502 - 2.108 1.895 -0.715
ENSG00000172943 E062 3.3411425 0.0199145405 7.265520e-01 8.195334e-01 X 54044875 54044949 75 - 0.647 0.609 -0.166
ENSG00000172943 E063 1.9261260 0.0182836921 7.575524e-01 8.423390e-01 X 54044950 54045249 300 - 0.403 0.469 0.351
ENSG00000172943 E064 0.0000000       X 54048905 54048958 54 -