ENSG00000172939

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000311806 ENSG00000172939 HEK293_OSMI2_2hA HEK293_TMG_2hB OXSR1 protein_coding protein_coding 20.31832 12.69376 27.3857 1.127995 0.8756789 1.108693 14.660716 8.013852 22.064012 1.0361254 0.8293295 1.4599819 0.6961375 0.6304333 0.8054 0.1749667 0.0417391100 0.0002568782 FALSE TRUE
MSTRG.22730.4 ENSG00000172939 HEK293_OSMI2_2hA HEK293_TMG_2hB OXSR1 protein_coding   20.31832 12.69376 27.3857 1.127995 0.8756789 1.108693 4.386955 4.400418 2.907052 0.7487149 0.3298905 -0.5964044 0.2489417 0.3494333 0.1056 -0.2438333 0.0002568782 0.0002568782 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000172939 E001 3.9878439 0.0050484464 1.067576e-02 3.039558e-02 3 38165089 38165383 295 + 0.764 0.412 -1.600
ENSG00000172939 E002 3.3976899 0.0138437829 8.696979e-03 2.552966e-02 3 38165384 38165455 72 + 0.716 0.313 -1.993
ENSG00000172939 E003 2.5988873 0.0060380919 1.765019e-01 2.966997e-01 3 38165456 38165504 49 + 0.580 0.413 -0.822
ENSG00000172939 E004 1.8572179 0.0304833924 2.412840e-01 3.756927e-01 3 38165505 38165514 10 + 0.478 0.313 -0.921
ENSG00000172939 E005 1.0467766 0.0454847433 2.934374e-01 4.344969e-01 3 38165515 38165536 22 + 0.343 0.184 -1.189
ENSG00000172939 E006 25.6682964 0.0007805375 3.398081e-04 1.539571e-03 3 38165537 38165646 110 + 1.445 1.266 -0.621
ENSG00000172939 E007 110.6844319 0.0187140464 1.044023e-02 2.983888e-02 3 38165647 38165946 300 + 2.045 1.953 -0.308
ENSG00000172939 E008 109.8238533 0.0111416426 7.436066e-02 1.505161e-01 3 38183003 38183115 113 + 2.019 2.006 -0.042
ENSG00000172939 E009 109.7149289 0.0028482893 1.052321e-03 4.140459e-03 3 38190731 38190839 109 + 2.030 1.984 -0.155
ENSG00000172939 E010 4.2395918 0.0036712536 8.777794e-02 1.717562e-01 3 38193282 38193418 137 + 0.749 0.562 -0.801
ENSG00000172939 E011 159.6317056 0.0064865050 6.067201e-05 3.347643e-04 3 38198722 38198863 142 + 2.205 2.101 -0.347
ENSG00000172939 E012 0.0000000       3 38216094 38216095 2 +      
ENSG00000172939 E013 100.5429385 0.0082808866 2.794327e-03 9.656979e-03 3 38216096 38216151 56 + 1.999 1.918 -0.272
ENSG00000172939 E014 135.2035612 0.0009050663 1.521190e-05 9.694705e-05 3 38221578 38221687 110 + 2.122 2.069 -0.177
ENSG00000172939 E015 119.4323416 0.0002773046 5.839438e-04 2.474697e-03 3 38223812 38223913 102 + 2.057 2.037 -0.066
ENSG00000172939 E016 144.4385208 0.0012203083 4.042046e-04 1.790775e-03 3 38224571 38224704 134 + 2.140 2.114 -0.088
ENSG00000172939 E017 0.1515154 0.0434998486 1.000000e+00   3 38224705 38225069 365 + 0.079 0.000 -10.390
ENSG00000172939 E018 99.8771472 0.0023107285 1.030309e-03 4.063220e-03 3 38229687 38229735 49 + 1.986 1.938 -0.164
ENSG00000172939 E019 97.9081461 0.0020945671 1.184272e-02 3.315571e-02 3 38230365 38230430 66 + 1.969 1.958 -0.038
ENSG00000172939 E020 0.2214452 0.0518108400 2.299766e-01   3 38230431 38230693 263 + 0.000 0.185 12.922
ENSG00000172939 E021 1.1887270 0.0113525485 6.493160e-01 7.606134e-01 3 38236661 38236838 178 + 0.343 0.313 -0.186
ENSG00000172939 E022 145.3992410 0.0002096391 9.441019e-02 1.820013e-01 3 38236839 38236961 123 + 2.121 2.170 0.164
ENSG00000172939 E023 3.6661872 0.0776142588 5.246277e-01 6.581077e-01 3 38242547 38242617 71 + 0.664 0.617 -0.200
ENSG00000172939 E024 77.5163768 0.0003526279 8.110256e-01 8.801520e-01 3 38242743 38242778 36 + 1.837 1.927 0.303
ENSG00000172939 E025 152.7169080 0.0002660348 5.986068e-02 1.263780e-01 3 38246075 38246221 147 + 2.144 2.187 0.145
ENSG00000172939 E026 101.6485683 0.0002752412 1.074865e-03 4.217689e-03 3 38247668 38247732 65 + 1.991 1.968 -0.076
ENSG00000172939 E027 95.9107180 0.0003111273 2.783853e-02 6.769602e-02 3 38249966 38250018 53 + 1.953 1.968 0.052
ENSG00000172939 E028 2.0379919 0.0070436984 1.688431e-01 2.866742e-01 3 38250019 38250179 161 + 0.506 0.314 -1.058
ENSG00000172939 E029 107.2137284 0.0002871031 5.182567e-02 1.124144e-01 3 38251403 38251471 69 + 1.996 2.026 0.100
ENSG00000172939 E030 102.0720073 0.0003244776 6.279357e-04 2.635485e-03 3 38252328 38252392 65 + 1.993 1.963 -0.098
ENSG00000172939 E031 1484.2937243 0.0091071611 2.300310e-08 2.651417e-07 3 38252817 38255484 2668 + 3.046 3.293 0.821