ENSG00000172936

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000396334 ENSG00000172936 HEK293_OSMI2_2hA HEK293_TMG_2hB MYD88 protein_coding protein_coding 1.794095 3.902367 0.607384 0.1913607 0.09019812 -2.663802 0.27693027 0.28721203 0.46399367 0.15845854 0.08834201 0.6733753 0.29070833 0.07150000 0.75883333 0.68733333 0.002064494 0.002064494 FALSE TRUE
ENST00000463956 ENSG00000172936 HEK293_OSMI2_2hA HEK293_TMG_2hB MYD88 protein_coding processed_transcript 1.794095 3.902367 0.607384 0.1913607 0.09019812 -2.663802 0.29047060 0.98004496 0.00000000 0.52244797 0.00000000 -6.6294221 0.13695000 0.26026667 0.00000000 -0.26026667 0.407970321 0.002064494 FALSE TRUE
ENST00000484513 ENSG00000172936 HEK293_OSMI2_2hA HEK293_TMG_2hB MYD88 protein_coding retained_intron 1.794095 3.902367 0.607384 0.1913607 0.09019812 -2.663802 0.04503573 0.04014856 0.03408564 0.04014856 0.02079644 -0.1858996 0.03556250 0.01030000 0.06596667 0.05566667 0.368229105 0.002064494 TRUE TRUE
ENST00000650905 ENSG00000172936 HEK293_OSMI2_2hA HEK293_TMG_2hB MYD88 protein_coding protein_coding 1.794095 3.902367 0.607384 0.1913607 0.09019812 -2.663802 0.74031204 1.55422195 0.00000000 0.82369919 0.00000000 -7.2893014 0.34448750 0.39430000 0.00000000 -0.39430000 0.344273759 0.002064494 FALSE TRUE
ENST00000652213 ENSG00000172936 HEK293_OSMI2_2hA HEK293_TMG_2hB MYD88 protein_coding protein_coding 1.794095 3.902367 0.607384 0.1913607 0.09019812 -2.663802 0.17175574 0.71132423 0.00000000 0.39268229 0.00000000 -6.1725760 0.05183333 0.17936667 0.00000000 -0.17936667 0.109119431 0.002064494 FALSE TRUE
ENST00000652590 ENSG00000172936 HEK293_OSMI2_2hA HEK293_TMG_2hB MYD88 protein_coding retained_intron 1.794095 3.902367 0.607384 0.1913607 0.09019812 -2.663802 0.05930231 0.21485355 0.08075665 0.11077413 0.04806748 -1.3089104 0.03706667 0.05616667 0.13896667 0.08280000 0.770350865 0.002064494 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000172936 E001 3.0099885 0.005937153 2.773775e-06 2.091976e-05 3 38138478 38138551 74 + 1.005 0.296 -3.221
ENSG00000172936 E002 1.9897157 0.008133366 7.445532e-04 3.059364e-03 3 38138552 38138632 81 + 0.800 0.230 -2.927
ENSG00000172936 E003 1.5489877 0.010936510 6.164408e-03 1.904482e-02 3 38138633 38138650 18 + 0.681 0.193 -2.763
ENSG00000172936 E004 1.2565659 0.013192372 8.719829e-02 1.708956e-01 3 38138651 38138656 6 + 0.515 0.193 -2.025
ENSG00000172936 E005 0.8868276 0.015986011 2.451358e-02 6.087810e-02 3 38138657 38138660 4 + 0.515 0.107 -3.025
ENSG00000172936 E006 18.9002563 0.007949367 3.047982e-01 4.468208e-01 3 38138661 38139028 368 + 1.229 1.124 -0.373
ENSG00000172936 E007 0.1817044 0.040021138 1.000000e+00   3 38139152 38139272 121 + 0.000 0.057 6.963
ENSG00000172936 E008 0.5503986 0.020953206 4.139127e-01 5.573250e-01 3 38139423 38139739 317 + 0.245 0.107 -1.441
ENSG00000172936 E009 0.0000000       3 38139740 38139780 41 +      
ENSG00000172936 E010 0.0000000       3 38139781 38139863 83 +      
ENSG00000172936 E011 15.6264208 0.002768144 9.544995e-02 1.835603e-01 3 38139864 38139998 135 + 1.209 1.038 -0.615
ENSG00000172936 E012 0.7061804 0.141852460 1.327259e-01 2.378902e-01 3 38139999 38140387 389 + 0.402 0.108 -2.430
ENSG00000172936 E013 19.1608354 0.001203144 7.287482e-01 8.211355e-01 3 38140388 38140549 162 + 1.166 1.133 -0.120
ENSG00000172936 E014 8.7090772 0.002511104 7.241257e-01 8.177411e-01 3 38140550 38140568 19 + 0.800 0.853 0.208
ENSG00000172936 E015 0.7383454 0.529313023 6.596732e-01 7.684506e-01 3 38140569 38140592 24 + 0.245 0.182 -0.544
ENSG00000172936 E016 2.4721710 0.006220789 8.747017e-02 1.712991e-01 3 38140593 38140756 164 + 0.681 0.379 -1.444
ENSG00000172936 E017 18.1739883 0.001204406 8.209007e-01 8.870931e-01 3 38140757 38140848 92 + 1.093 1.119 0.094
ENSG00000172936 E018 137.9116838 0.002146932 1.558047e-07 1.525018e-06 3 38141132 38143022 1891 + 1.816 1.994 0.597