ENSG00000172893

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000355527 ENSG00000172893 HEK293_OSMI2_2hA HEK293_TMG_2hB DHCR7 protein_coding protein_coding 134.4959 211.0666 68.97023 12.32322 1.572452 -1.613512 115.996041 185.341024 55.812394 10.053327 1.9172298 -1.7313442 0.85346667 0.8785333 0.8088 -0.06973333 0.0001368228 0.0001368228 FALSE  
MSTRG.5882.16 ENSG00000172893 HEK293_OSMI2_2hA HEK293_TMG_2hB DHCR7 protein_coding   134.4959 211.0666 68.97023 12.32322 1.572452 -1.613512 5.392146 3.324046 5.638068 2.371164 0.1902267 0.7604833 0.04907917 0.0153000 0.0818 0.06650000 0.0285372610 0.0001368228 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000172893 E001 1.1750080 1.186210e-02 2.450082e-01 3.800391e-01 11 71428193 71428852 660 - 0.442 0.236 -1.291
ENSG00000172893 E002 18.2773519 6.526235e-03 1.137387e-03 4.428622e-03 11 71434411 71434413 3 - 0.838 1.250 1.512
ENSG00000172893 E003 18.9468989 1.065744e-02 2.501412e-03 8.767044e-03 11 71434414 71434420 7 - 0.873 1.263 1.420
ENSG00000172893 E004 122.1777131 9.343411e-03 5.835686e-05 3.233496e-04 11 71434421 71434442 22 - 1.755 2.041 0.965
ENSG00000172893 E005 411.3818299 4.349438e-03 6.262661e-12 1.347464e-10 11 71434443 71434543 101 - 2.264 2.567 1.009
ENSG00000172893 E006 2109.8823029 3.020078e-03 3.618385e-13 9.508840e-12 11 71434544 71434964 421 - 3.045 3.266 0.735
ENSG00000172893 E007 1806.7211334 2.743185e-03 4.057372e-06 2.946626e-05 11 71434965 71435190 226 - 3.043 3.187 0.479
ENSG00000172893 E008 1184.9370353 9.944240e-04 7.880470e-05 4.223166e-04 11 71435191 71435285 95 - 2.898 2.996 0.325
ENSG00000172893 E009 746.7341618 6.966549e-04 5.093888e-07 4.499565e-06 11 71435286 71435307 22 - 2.676 2.799 0.411
ENSG00000172893 E010 894.6092446 2.340958e-04 4.717965e-11 8.798152e-10 11 71435308 71435374 67 - 2.750 2.877 0.424
ENSG00000172893 E011 988.3643866 2.157904e-04 6.462151e-06 4.485035e-05 11 71435375 71435441 67 - 2.824 2.913 0.294
ENSG00000172893 E012 2124.6915829 7.480376e-05 6.774426e-08 7.111401e-07 11 71435442 71435839 398 - 3.170 3.242 0.238
ENSG00000172893 E013 67.9628867 4.222474e-04 6.778825e-01 7.824885e-01 11 71435840 71435973 134 - 1.712 1.751 0.129
ENSG00000172893 E014 55.1712390 4.964483e-04 6.106035e-02 1.284187e-01 11 71436580 71437803 1224 - 1.722 1.635 -0.296
ENSG00000172893 E015 7.3415438 6.170920e-02 6.729880e-01 7.787795e-01 11 71437804 71437811 8 - 0.874 0.815 -0.229
ENSG00000172893 E016 1342.5118641 5.233232e-04 1.939990e-01 3.188165e-01 11 71437812 71437943 132 - 3.031 3.030 -0.004
ENSG00000172893 E017 8.7712933 1.099221e-02 7.974188e-01 8.707275e-01 11 71438749 71438878 130 - 0.906 0.887 -0.074
ENSG00000172893 E018 1856.7526556 7.730868e-04 2.840904e-04 1.315155e-03 11 71438879 71439083 205 - 3.201 3.164 -0.122
ENSG00000172893 E019 9.0833291 1.844889e-03 2.644469e-04 1.234809e-03 11 71439084 71439749 666 - 1.196 0.806 -1.444
ENSG00000172893 E020 4.0652793 2.395727e-01 2.188260e-01 3.490027e-01 11 71440472 71440785 314 - 0.840 0.540 -1.260
ENSG00000172893 E021 1.4244666 1.094286e-01 2.080641e-01 3.361629e-01 11 71440786 71440836 51 - 0.525 0.277 -1.393
ENSG00000172893 E022 6.4379255 3.558020e-02 1.445982e-03 5.459632e-03 11 71440837 71441226 390 - 1.106 0.662 -1.712
ENSG00000172893 E023 1608.6545182 7.775490e-04 1.734329e-05 1.090920e-04 11 71441227 71441440 214 - 3.149 3.099 -0.166
ENSG00000172893 E024 1021.5468753 2.157210e-04 2.662844e-10 4.365796e-09 11 71442263 71442353 91 - 2.969 2.895 -0.245
ENSG00000172893 E025 10.8099571 3.034867e-02 7.014374e-01 8.006118e-01 11 71443957 71443992 36 - 0.906 0.985 0.298
ENSG00000172893 E026 587.2304428 2.703785e-04 1.687584e-09 2.397148e-08 11 71443993 71443996 4 - 2.744 2.650 -0.314
ENSG00000172893 E027 806.2094923 2.249288e-04 2.272069e-12 5.260133e-11 11 71443997 71444033 37 - 2.881 2.787 -0.313
ENSG00000172893 E028 583.8195276 5.015241e-04 2.018863e-09 2.822639e-08 11 71444034 71444040 7 - 2.747 2.645 -0.337
ENSG00000172893 E029 679.5783874 6.257968e-04 3.950251e-08 4.349431e-07 11 71444041 71444061 21 - 2.804 2.714 -0.297
ENSG00000172893 E030 935.1798488 4.221016e-04 2.570432e-09 3.532284e-08 11 71444062 71444119 58 - 2.935 2.855 -0.264
ENSG00000172893 E031 1027.3555660 3.323282e-04 1.239029e-10 2.153094e-09 11 71444120 71444215 96 - 2.976 2.896 -0.266
ENSG00000172893 E032 3.3829571 5.095767e-03 7.223685e-01 8.164868e-01 11 71444216 71444253 38 - 0.595 0.547 -0.220
ENSG00000172893 E033 1.0684302 1.219891e-02 7.186936e-01 8.136947e-01 11 71444254 71444286 33 - 0.201 0.279 0.616
ENSG00000172893 E034 1049.3111621 1.024870e-03 1.803265e-03 6.609715e-03 11 71444855 71444958 104 - 2.957 2.915 -0.139
ENSG00000172893 E035 812.4244525 9.238621e-04 1.890927e-02 4.913396e-02 11 71447610 71447702 93 - 2.836 2.807 -0.097
ENSG00000172893 E036 438.7228927 8.020294e-04 5.005784e-02 1.092702e-01 11 71447703 71447726 24 - 2.567 2.538 -0.097
ENSG00000172893 E037 367.7975774 1.712974e-03 3.304079e-02 7.788617e-02 11 71447727 71447734 8 - 2.503 2.459 -0.147
ENSG00000172893 E038 10.1487325 3.598491e-02 3.325692e-01 4.762441e-01 11 71447735 71448071 337 - 1.041 0.922 -0.441
ENSG00000172893 E039 1.1395059 1.323620e-02 7.179025e-01 8.131612e-01 11 71448267 71448276 10 - 0.201 0.279 0.618
ENSG00000172893 E040 5.0372869 5.170654e-03 8.653584e-01 9.172646e-01 11 71448277 71448289 13 - 0.709 0.696 -0.054
ENSG00000172893 E041 364.8668800 1.458108e-03 1.354873e-03 5.159329e-03 11 71448290 71448312 23 - 2.522 2.449 -0.242
ENSG00000172893 E042 291.7215973 1.749395e-03 3.399610e-06 2.514429e-05 11 71448313 71448435 123 - 2.464 2.339 -0.419
ENSG00000172893 E043 0.4460135 2.591906e-02 5.829371e-03 1.816197e-02 11 71452694 71452868 175 - 0.442 0.000 -12.209