ENSG00000172888

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000310898 ENSG00000172888 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF621 protein_coding protein_coding 8.491582 4.55896 10.8294 0.2984749 0.1638028 1.246347 1.6091769 1.39952140 1.229731 0.2181528 0.1591001 -0.1851788 0.21696667 0.307266667 0.1138667 -0.1934 2.416463e-03 1.393941e-09 FALSE TRUE
ENST00000339296 ENSG00000172888 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF621 protein_coding protein_coding 8.491582 4.55896 10.8294 0.2984749 0.1638028 1.246347 5.4333720 2.93968982 7.245659 0.3023892 0.4721329 1.2985434 0.63592917 0.643733333 0.6684333 0.0247 8.897182e-01 1.393941e-09 FALSE TRUE
ENST00000431278 ENSG00000172888 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF621 protein_coding protein_coding 8.491582 4.55896 10.8294 0.2984749 0.1638028 1.246347 0.8488575 0.02886839 1.621120 0.0161800 0.1460434 5.3911217 0.08308333 0.006766667 0.1501667 0.1434 1.393941e-09 1.393941e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000172888 E001 1.102977 0.0116057297 3.760386e-01 5.204172e-01 3 40524878 40524897 20 + 0.344 0.184 -1.194
ENSG00000172888 E002 4.474755 0.0035974722 1.589761e-01 2.737610e-01 3 40524898 40524959 62 + 0.765 0.560 -0.873
ENSG00000172888 E003 7.064090 0.0023109824 1.630660e-01 2.791395e-01 3 40524960 40524982 23 + 0.926 0.759 -0.650
ENSG00000172888 E004 13.720272 0.0113222642 3.184966e-02 7.556265e-02 3 40524983 40525005 23 + 1.201 0.974 -0.821
ENSG00000172888 E005 19.797727 0.0009344423 4.873733e-03 1.557810e-02 3 40525006 40525038 33 + 1.348 1.118 -0.814
ENSG00000172888 E006 46.237850 0.0005309253 3.910049e-09 5.194944e-08 3 40525039 40525274 236 + 1.725 1.374 -1.200
ENSG00000172888 E007 0.746968 0.0163292270 1.363820e-01 2.430087e-01 3 40525416 40525460 45 + 0.302 0.000 -10.393
ENSG00000172888 E008 40.359369 0.0005992126 3.125881e-07 2.881417e-06 3 40525779 40525864 86 + 1.663 1.344 -1.096
ENSG00000172888 E009 1.927261 0.0073233287 7.820243e-01 8.600247e-01 3 40529288 40529318 31 + 0.449 0.412 -0.194
ENSG00000172888 E010 28.309846 0.0106001791 3.355266e-02 7.887747e-02 3 40529319 40529445 127 + 1.483 1.312 -0.593
ENSG00000172888 E011 2.318772 0.0064442299 4.502739e-01 5.913900e-01 3 40529495 40529575 81 + 0.533 0.412 -0.610
ENSG00000172888 E012 43.629757 0.0024511002 1.469658e-02 3.980645e-02 3 40530209 40530316 108 + 1.659 1.527 -0.453
ENSG00000172888 E013 62.460852 0.0053222083 6.004715e-03 1.862252e-02 3 40532030 40532206 177 + 1.811 1.666 -0.490
ENSG00000172888 E014 948.972249 0.0004057726 1.251364e-05 8.131270e-05 3 40532207 40538285 6079 + 2.949 2.933 -0.053
ENSG00000172888 E015 320.752953 0.0022725391 1.003927e-25 1.175469e-23 3 40538286 40539794 1509 + 2.359 2.651 0.972
ENSG00000172888 E016 2.647533 0.0056471429 1.050508e-03 4.134358e-03 3 40574383 40574685 303 + 0.302 0.832 2.527