ENSG00000172845

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000310015 ENSG00000172845 HEK293_OSMI2_2hA HEK293_TMG_2hB SP3 protein_coding protein_coding 15.57732 3.119576 28.22329 0.3137156 0.1545278 3.173358 1.0077842 0.37335919 1.789993 0.01538420 0.1033836 2.231222 0.09722500 0.12306667 0.06346667 -0.05960000 4.951287e-02 2.323288e-07 FALSE TRUE
ENST00000416195 ENSG00000172845 HEK293_OSMI2_2hA HEK293_TMG_2hB SP3 protein_coding protein_coding 15.57732 3.119576 28.22329 0.3137156 0.1545278 3.173358 7.9657159 2.38231974 12.846046 0.28497838 0.5497852 2.425965 0.57453750 0.76150000 0.45536667 -0.30613333 2.323288e-07 2.323288e-07 FALSE TRUE
ENST00000418194 ENSG00000172845 HEK293_OSMI2_2hA HEK293_TMG_2hB SP3 protein_coding protein_coding 15.57732 3.119576 28.22329 0.3137156 0.1545278 3.173358 1.2575510 0.06081195 3.138247 0.03486873 0.9193479 5.474412 0.08329583 0.02026667 0.11133333 0.09106667 9.420910e-02 2.323288e-07 FALSE TRUE
ENST00000652005 ENSG00000172845 HEK293_OSMI2_2hA HEK293_TMG_2hB SP3 protein_coding protein_coding 15.57732 3.119576 28.22329 0.3137156 0.1545278 3.173358 1.0224900 0.04767034 1.592896 0.04767034 0.4430646 4.796707 0.05159583 0.01356667 0.05630000 0.04273333 2.160220e-01 2.323288e-07 FALSE TRUE
MSTRG.19510.6 ENSG00000172845 HEK293_OSMI2_2hA HEK293_TMG_2hB SP3 protein_coding   15.57732 3.119576 28.22329 0.3137156 0.1545278 3.173358 0.2642207 0.00000000 1.551109 0.00000000 0.7755543 7.286427 0.01017917 0.00000000 0.05516667 0.05516667 4.873065e-01 2.323288e-07 TRUE TRUE
MSTRG.19510.8 ENSG00000172845 HEK293_OSMI2_2hA HEK293_TMG_2hB SP3 protein_coding   15.57732 3.119576 28.22329 0.3137156 0.1545278 3.173358 1.1433162 0.02812891 2.411439 0.01425681 0.5613308 5.988835 0.04582917 0.00970000 0.08566667 0.07596667 4.285902e-03 2.323288e-07 FALSE TRUE
MSTRG.19510.9 ENSG00000172845 HEK293_OSMI2_2hA HEK293_TMG_2hB SP3 protein_coding   15.57732 3.119576 28.22329 0.3137156 0.1545278 3.173358 2.1230133 0.00000000 3.633557 0.00000000 1.8365691 8.509204 0.07805417 0.00000000 0.12810000 0.12810000 4.124392e-01 2.323288e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000172845 E001 0.0000000       2 173880850 173880864 15 -      
ENSG00000172845 E002 0.4031496 0.0263197722 5.153750e-03 1.634791e-02 2 173880865 173881061 197 - 0.000 0.472 14.103
ENSG00000172845 E003 0.4428904 0.4056919339 1.746247e-02 4.596079e-02 2 173881525 173881690 166 - 0.000 0.485 15.096
ENSG00000172845 E004 0.2214452 0.0380412710 4.203047e-02   2 173881691 173881797 107 - 0.000 0.297 15.187
ENSG00000172845 E005 0.4482035 0.0280318123 1.000000e+00 1.000000e+00 2 173883276 173883488 213 - 0.122 0.000 -12.931
ENSG00000172845 E006 0.1451727 0.0433717585 7.228178e-01   2 173897975 173898029 55 - 0.045 0.000 -11.326
ENSG00000172845 E007 0.0000000       2 173899391 173899428 38 -      
ENSG00000172845 E008 179.8202834 0.0096082239 9.100767e-08 9.307958e-07 2 173900775 173907559 6785 - 2.009 2.363 1.185
ENSG00000172845 E009 6.6611574 0.0041205318 5.613813e-01 6.892146e-01 2 173907560 173907588 29 - 0.735 0.691 -0.181
ENSG00000172845 E010 12.7800662 0.0236327471 9.474583e-01 9.709564e-01 2 173907589 173907825 237 - 0.960 1.031 0.266
ENSG00000172845 E011 3.8042892 0.0055407028 9.447465e-01 9.693040e-01 2 173907826 173907826 1 - 0.529 0.595 0.304
ENSG00000172845 E012 8.8894882 0.0153171843 4.716541e-01 6.107383e-01 2 173907827 173907885 59 - 0.835 0.770 -0.256
ENSG00000172845 E013 7.6704704 0.0092333403 3.952286e-01 5.390443e-01 2 173907886 173907898 13 - 0.784 0.691 -0.378
ENSG00000172845 E014 14.9450379 0.0074554466 7.317425e-02 1.486005e-01 2 173907899 173907965 67 - 1.044 0.837 -0.776
ENSG00000172845 E015 20.1022648 0.0016174316 1.267013e-03 4.867123e-03 2 173907966 173908529 564 - 1.077 1.454 1.327
ENSG00000172845 E016 3.4353649 0.0046484344 1.441295e-01 2.536286e-01 2 173908530 173908531 2 - 0.453 0.771 1.412
ENSG00000172845 E017 9.4595790 0.0366981215 3.586921e-08 3.976659e-07 2 173908532 173908557 26 - 0.639 1.461 3.057
ENSG00000172845 E018 375.3948478 0.0066306208 4.999579e-19 2.852877e-17 2 173908558 173909944 1387 - 2.314 2.719 1.348
ENSG00000172845 E019 124.1428084 0.0013715727 3.116474e-01 4.541136e-01 2 173909945 173910164 220 - 1.905 1.926 0.072
ENSG00000172845 E020 93.3930066 0.0032221039 5.849197e-01 7.087296e-01 2 173910165 173910257 93 - 1.780 1.818 0.130
ENSG00000172845 E021 165.0678951 0.0002109646 1.482706e-03 5.581159e-03 2 173913070 173913266 197 - 2.038 1.973 -0.217
ENSG00000172845 E022 4.5012860 0.0396244140 8.057305e-01 8.765034e-01 2 173913267 173916832 3566 - 0.594 0.594 -0.001
ENSG00000172845 E023 159.2959184 0.0007220510 1.359331e-06 1.097002e-05 2 173918593 173918785 193 - 2.031 1.872 -0.534
ENSG00000172845 E024 0.7384352 0.0181973276 7.085585e-01 8.061837e-01 2 173934370 173934411 42 - 0.188 0.000 -13.660
ENSG00000172845 E025 446.0348532 0.0085194904 3.072806e-07 2.836610e-06 2 173954873 173955816 944 - 2.476 2.309 -0.557
ENSG00000172845 E026 181.0662119 0.0002097333 2.484930e-08 2.843628e-07 2 173955817 173956073 257 - 2.087 1.915 -0.578
ENSG00000172845 E027 47.2455926 0.0044855687 4.927851e-02 1.078844e-01 2 173956074 173956080 7 - 1.509 1.406 -0.354
ENSG00000172845 E028 79.8201638 0.0027981864 2.602318e-04 1.217729e-03 2 173956081 173956228 148 - 1.739 1.547 -0.650
ENSG00000172845 E029 23.4230035 0.0062846717 2.542820e-03 8.891117e-03 2 173956229 173956232 4 - 1.239 0.895 -1.254
ENSG00000172845 E030 2.5472871 0.0991701347 3.972219e-04 1.763634e-03 2 173962972 173963379 408 - 0.245 0.986 3.519
ENSG00000172845 E031 40.6845650 0.0016226113 3.459799e-06 2.555654e-05 2 173963761 173963874 114 - 1.471 1.033 -1.545
ENSG00000172845 E032 17.1334373 0.0010258495 1.784883e-03 6.550829e-03 2 173963875 173963883 9 - 1.114 0.692 -1.617
ENSG00000172845 E033 19.5416251 0.0107674438 3.099326e-03 1.055774e-02 2 173963884 173964188 305 - 1.165 0.771 -1.477
ENSG00000172845 E034 2.0555986 0.1015220143 1.732567e-01 2.924329e-01 2 173964189 173964404 216 - 0.400 0.000 -14.835
ENSG00000172845 E035 16.9352190 0.0314906770 8.075898e-03 2.397334e-02 2 173964405 173964553 149 - 1.110 0.692 -1.599
ENSG00000172845 E036 0.1482932 0.0412986143 4.254802e-02   2 173964851 173964885 35 - 0.000 0.296 15.142
ENSG00000172845 E037 8.8737684 0.0371651611 3.884858e-02 8.890289e-02 2 173965165 173965187 23 - 0.861 0.470 -1.680
ENSG00000172845 E038 12.3081011 0.0169813734 6.360768e-01 7.501935e-01 2 173965188 173965462 275 - 0.954 0.946 -0.032