ENSG00000172840

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000311765 ENSG00000172840 HEK293_OSMI2_2hA HEK293_TMG_2hB PDP2 protein_coding protein_coding 6.775109 5.736061 7.811867 0.9193968 0.1011083 0.4449398 3.7622934 2.2772796 4.6892090 0.32731737 0.21995115 1.038785 0.5408167 0.3989667 0.6011000 0.20213333 2.365221e-03 7.031947e-26 FALSE TRUE
ENST00000561475 ENSG00000172840 HEK293_OSMI2_2hA HEK293_TMG_2hB PDP2 protein_coding processed_transcript 6.775109 5.736061 7.811867 0.9193968 0.1011083 0.4449398 1.0842597 2.3965514 0.0000000 0.64571557 0.00000000 -7.910823 0.1941542 0.4047000 0.0000000 -0.40470000 7.031947e-26 7.031947e-26   FALSE
ENST00000561704 ENSG00000172840 HEK293_OSMI2_2hA HEK293_TMG_2hB PDP2 protein_coding protein_coding 6.775109 5.736061 7.811867 0.9193968 0.1011083 0.4449398 0.7029377 0.3768289 1.3637313 0.19344570 0.26439265 1.828332 0.0935250 0.0758000 0.1738667 0.09806667 2.639198e-01 7.031947e-26 FALSE TRUE
ENST00000568398 ENSG00000172840 HEK293_OSMI2_2hA HEK293_TMG_2hB PDP2 protein_coding protein_coding 6.775109 5.736061 7.811867 0.9193968 0.1011083 0.4449398 0.5352606 0.2478741 0.9571761 0.03369823 0.08672458 1.907112 0.0732500 0.0435000 0.1227000 0.07920000 1.342203e-03 7.031947e-26   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000172840 E001 0.0000000       16 66878589 66878639 51 +      
ENSG00000172840 E002 0.0000000       16 66880515 66880518 4 +      
ENSG00000172840 E003 0.0000000       16 66880519 66880519 1 +      
ENSG00000172840 E004 0.0000000       16 66880520 66880530 11 +      
ENSG00000172840 E005 3.0063033 0.0071005377 1.866486e-01 3.095295e-01 16 66880531 66880548 18 + 0.654 0.493 -0.733
ENSG00000172840 E006 7.2715890 0.0033714161 5.865865e-02 1.243338e-01 16 66880549 66880581 33 + 0.979 0.812 -0.635
ENSG00000172840 E007 11.7347154 0.0014947471 3.540139e-03 1.184090e-02 16 66880582 66880606 25 + 1.184 0.955 -0.833
ENSG00000172840 E008 16.4707698 0.0011400776 1.676130e-04 8.249237e-04 16 66880607 66880640 34 + 1.329 1.063 -0.943
ENSG00000172840 E009 7.3813865 0.0023366987 1.117582e-01 2.081425e-01 16 66880641 66880664 24 + 0.967 0.840 -0.484
ENSG00000172840 E010 2.6624744 0.0058136217 1.317147e-01 2.365113e-01 16 66880665 66880673 9 + 0.629 0.430 -0.947
ENSG00000172840 E011 3.5397500 0.0044791690 3.781513e-01 5.224479e-01 16 66880674 66880756 83 + 0.678 0.598 -0.346
ENSG00000172840 E012 5.5121036 0.0440013977 2.380372e-01 3.718628e-01 16 66883015 66883102 88 + 0.862 0.718 -0.569
ENSG00000172840 E013 15.7925974 0.0065706359 1.464344e-02 3.969200e-02 16 66884231 66884277 47 + 1.280 1.109 -0.608
ENSG00000172840 E014 26.1983889 0.0007961982 1.368810e-05 8.809217e-05 16 66884278 66884370 93 + 1.513 1.273 -0.832
ENSG00000172840 E015 28.7971214 0.0008143919 1.021198e-03 4.032325e-03 16 66884371 66884468 98 + 1.526 1.377 -0.515
ENSG00000172840 E016 273.1119521 0.0062918267 3.345815e-05 1.966538e-04 16 66884469 66886546 2078 + 2.467 2.381 -0.289
ENSG00000172840 E017 27.3853998 0.0007417757 8.637977e-04 3.486755e-03 16 66886547 66886645 99 + 1.510 1.353 -0.541
ENSG00000172840 E018 147.4220785 0.0002235688 1.713171e-02 4.523165e-02 16 66886646 66888014 1369 + 2.169 2.174 0.017
ENSG00000172840 E019 12.9022813 0.0016907382 8.664717e-01 9.180470e-01 16 66888015 66888112 98 + 1.123 1.174 0.181
ENSG00000172840 E020 13.3974984 0.0013875850 7.374654e-01 8.276270e-01 16 66888113 66888273 161 + 1.139 1.174 0.124
ENSG00000172840 E021 358.0930037 0.0063257400 3.156630e-16 1.276444e-14 16 66888274 66891101 2828 + 2.398 2.704 1.018
ENSG00000172840 E022 1.2586568 0.0106601992 8.319761e-01 8.947103e-01 16 66892554 66892651 98 + 0.353 0.355 0.015
ENSG00000172840 E023 0.2966881 0.0273614987 3.309124e-01   16 66892896 66893000 105 + 0.177 0.000 -8.807
ENSG00000172840 E024 0.9683114 0.0140805244 6.703003e-01 7.767844e-01 16 66894995 66895033 39 + 0.244 0.355 0.752
ENSG00000172840 E025 1.5101892 0.0094430516 2.734561e-02 6.669856e-02 16 66895034 66895590 557 + 0.176 0.597 2.559
ENSG00000172840 E026 1.7163236 0.1141158100 7.690413e-01 8.507744e-01 16 66895591 66895754 164 + 0.441 0.427 -0.074